A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Search Luxury Hotels in Southeast Missouri

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Luxury Hotels

Tonight
8 Aug - 9 Aug
Tomorrow
9 Aug - 10 Aug
Next weekend
14 Aug - 16 Aug
In two weeks
21 Aug - 23 Aug

Our top choices for Southeast Missouri luxury hotels

1. The Riverview

The Riverview
Cape Girardeau
₹10,229
₹11,540 total
includes taxes & fees
9 Aug - 10 Aug
The Riverview

2. River City Casino & Hotel

River City Casino & Hotel
St. Louis
₹9,459
₹12,396 total
includes taxes & fees
13 Aug - 14 Aug
River City Casino & Hotel

3. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
₹12,947
₹15,371 total
includes taxes & fees
30 Aug - 31 Aug
Drury Plaza Hotel St. Louis Brentwood

4. Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
Frontenac
  • Upscale St. Louis retreat features pool, concierge, fine dining in prime business district.
₹13,975
₹16,279 total
includes taxes & fees
16 Aug - 17 Aug
Hilton St. Louis Frontenac
View all properties

Find out more about Southeast Missouri

Southeast Missouriand its attractions for luxury travelers

Southeast Missouri boasts a compelling blend of natural beauty and cultural richness, perfect for the discerning traveller seeking luxury. Begin your journey in Cape Girardeau, where the historic Riverfront adds charm to your stay; indulge in a gourmet meal at a riverside restaurant followed by a leisurely stroll along the Mississippi River. For a touch of adventure, head to the stunning trails of the Ozark National Scenic Riverways, where you can explore crystal-clear springs and enjoy a private guided canoe tour, immersing yourself in Missouri's breathtaking landscapes. The historic town of Ste. Genevieve, rich in French historic architecture, offers boutique shopping and exquisite dining experiences that cater to refined tastes. The region’s acclaimed wineries, such as the nearby Chaumette Vineyards, provide exclusive tastings and vineyard tours, perfect for an afternoon of indulgence. For a luxurious stay, consider the upscale options in Cape Girardeau, where hotels offer stunning views of the river along with top amenities and personalised services, ensuring that you feel pampered throughout your visit.

Top Southeast Missouri Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"The manager and staff are excellent"
Robbie 2-night trip
Posted 1 day ago
Days Inn and Suites by Wyndham Sikeston
Baymont by Wyndham Festus

Baymont by Wyndham Festus

10/10 Excellent
"The staff and everything was wonderful."
Zakkary 10-night trip
Posted 2 days ago
Baymont by Wyndham Festus
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

8/10 Good
"Great place to stay in the area and a good value for the money spent. Just South of St. Louis and plenty of places to shop, eat and go on adventures. The water pressure in the shower was weak but we got by."
Jeff 2-night trip
Posted 4 days ago
Comfort Inn Festus - St Louis South

Explore a world of travel with Expedia