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Our top choices for Southeast Missouri luxury hotels

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely
2.0 star property
Pevely
5.6 out of 10, (832 reviews)
"Awesome "
United States
monica
Super 8 by Wyndham Pevely

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
"Very clean and staff was very friendly!"
United States
Sherry
The price is ₹5,232
₹5,518 total
includes taxes & fees
31 Jan - 1 Feb
Motel 6 Poplar Bluff, MO

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,001 reviews)
"Everything was excellent"
United States
James
The price is ₹5,773
₹6,580 total
includes taxes & fees
1 Feb - 2 Feb
Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,001 reviews)
"Staff great. "
United States
Nancy
Pear Tree Inn Cape Girardeau Near the Medical Center

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (916 reviews)
"Great stay"
United States
Judy
The price is ₹6,535
₹7,636 total
includes taxes & fees
8 Feb - 9 Feb
Comfort Inn Festus - St Louis South

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (633 reviews)
"Very clean and staff was great"
United States
Dawn
The price is ₹4,837
₹5,465 total
includes taxes & fees
9 Feb - 10 Feb
Super 8 by Wyndham Poplar Bluff Missouri

Baymont by Wyndham Festus

Baymont by Wyndham Festus
3.0 star property
Festus
6.8 out of 10, (929 reviews)
"Room was good and staff was helpful and friendly"
United States
Michael
The price is ₹7,435
₹8,501 total
includes taxes & fees
1 Feb - 2 Feb
Baymont by Wyndham Festus

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (694 reviews)
"The room was clean and nice. The breakfast was really good."
United States
Kalani
The price is ₹5,481
₹6,184 total
includes taxes & fees
10 Feb - 11 Feb
Quality Inn Cape Girardeau North

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,001 reviews)
"As always it was a perfect visit"
United States
John
The price is ₹8,260
₹9,497 total
includes taxes & fees
3 Feb - 4 Feb
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Awesome stay!"
United States
Breckin
The price is ₹8,260
₹9,318 total
includes taxes & fees
3 Feb - 4 Feb
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southeast Missouri

Southeast Missouriand its attractions for luxury travelers

Southeast Missouri boasts a compelling blend of natural beauty and cultural richness, perfect for the discerning traveller seeking luxury. Begin your journey in Cape Girardeau, where the historic Riverfront adds charm to your stay; indulge in a gourmet meal at a riverside restaurant followed by a leisurely stroll along the Mississippi River. For a touch of adventure, head to the stunning trails of the Ozark National Scenic Riverways, where you can explore crystal-clear springs and enjoy a private guided canoe tour, immersing yourself in Missouri's breathtaking landscapes. The historic town of Ste. Genevieve, rich in French historic architecture, offers boutique shopping and exquisite dining experiences that cater to refined tastes. The region’s acclaimed wineries, such as the nearby Chaumette Vineyards, provide exclusive tastings and vineyard tours, perfect for an afternoon of indulgence. For a luxurious stay, consider the upscale options in Cape Girardeau, where hotels offer stunning views of the river along with top amenities and personalised services, ensuring that you feel pampered throughout your visit.

Top Southeast Missouri Hotel Reviews