Search Luxury Hotels in Southeast Missouri

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Luxury Hotels

Tonight
22 Jul - 23 Jul
Tomorrow
23 Jul - 24 Jul
This weekend
25 Jul - 27 Jul
Next weekend
1 Aug - 3 Aug

Top Southeast Missouri Luxury Hotels

Super 8 by Wyndham Pevely
Desk, laptop workspace, blackout curtains, rollaway beds

Super 8 by Wyndham Pevely

2.0 star property
5.6 out of 10, (825)
"Arrived during tornado warning/ watch. Staff aware of danger. Very helpful"
Super 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO
Relax in a stylish space with a seating area, kitchenette, and reception desk, offering a view of the outdoors.

Motel 6 Poplar Bluff, MO

2.0 star property
7.8 out of 10, Good, (1008)
"Great place for what we needed."
The price is ₹6,818
₹7,191 total
includes taxes & fees
24 Jul - 25 Jul
Motel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston
Two single beds with dark headboards and white bedding, accompanied by a small table and framed landscape paintings.

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1003)
"We were there to get a good nights sleep and we did."
The price is ₹6,235
₹7,107 total
includes taxes & fees
27 Jul - 28 Jul
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Enjoy meals in the dining area with a view, featuring a long counter, TV, and comfortable seating options.

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Excellent place to stay "
The price is ₹6,040
₹6,814 total
includes taxes & fees
24 Jul - 25 Jul
Pear Tree Inn Cape Girardeau Near the Medical Center
Comfort Inn Festus - St Louis South
Relax in our inviting lobby, featuring a central seating area, dining tables, and comfortable furniture.

Comfort Inn Festus - St Louis South

2.5 star property
8.0 out of 10, Very good, (844)
"Great Front Desk and easy check in "
The price is ₹6,895
₹8,057 total
includes taxes & fees
6 Aug - 7 Aug
Comfort Inn Festus - St Louis South
Super 8 by Wyndham Poplar Bluff Missouri
Relax in a spacious room with a large bed, a framed historic landmark print, and convenient bedside amenities.

Super 8 by Wyndham Poplar Bluff Missouri

2.0 star property
6.6 out of 10, (585)
"It was a great stay"
The price is ₹5,135
₹5,801 total
includes taxes & fees
4 Aug - 5 Aug
Super 8 by Wyndham Poplar Bluff Missouri
Quality Inn Festus
Enjoy dining or events in this elegant space with a central fountain and pool, surrounded by tables and chairs.

Quality Inn Festus

3.0 star property
6.8 out of 10, (896)
"Great place to stay "
Quality Inn Festus
Quality Inn
Relax in this stylish living area with a high ceiling, sofas, coffee table, and flat-screen TV.

Quality Inn

2.5 star property
7.0 out of 10, Good, (615)
"Great room, great experience "
The price is ₹5,782
₹6,523 total
includes taxes & fees
24 Jul - 25 Jul
Quality Inn
Drury Inn & Suites Sikeston, MO
Relax in the serene courtyard, surrounded by lush greenery and comfortable seating.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1005)
"Will stay again"
The price is ₹8,802
₹10,120 total
includes taxes & fees
27 Jul - 28 Jul
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau
Reception area with a reception desk, flat-screen TV, and seating area.

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (962)
"Love the property. Staff is always amazing."
The price is ₹7,766
₹8,760 total
includes taxes & fees
27 Jul - 28 Jul
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southeast Missouri Hotel Reviews

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"Very nice check in. Pleased with room. Had a little smell Breakfast had everything plus more!"
Janet 1-night trip
Posted 3 days ago
Comfort Inn Festus - St Louis South