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Search Hotels Suites in Southeast Missouri

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Check availability on Southeast Missouri Hotels Suites

Tonight
5 Dec - 6 Dec
Tomorrow
6 Dec - 7 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Southeast Missouri Hotels Suites

Front of property
Echo Bluff State Park

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is ₹13,757
₹14,545 total
includes taxes & fees
5 Jan - 6 Jan 2026
Echo Bluff State Park
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
The price is ₹8,097
₹9,309 total
includes taxes & fees
10 Dec - 11 Dec
Drury Inn & Suites Sikeston, MO
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1000)
"Great place and staff, very accommodating!"
United States
Megan
The price is ₹8,097
₹9,133 total
includes taxes & fees
11 Dec - 12 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (955)
"Delicious, well-ran breakfast and quiet peaceful hotel. "
United States
Janene
The price is ₹8,457
₹9,553 total
includes taxes & fees
18 Dec - 19 Dec
Drury Inn & Suites Poplar Bluff
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (695)
"Amazing place"
United States
Mladen
The price is ₹8,926
₹10,084 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Poplar Bluff by IHG
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (536)
"Clean room and pleasant staff"
United States
David
The price is ₹7,828
₹8,961 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express & Suites Perryville by IHG
Front of property
The Farmstead Hotel

The Farmstead Hotel

2.5 star property
Caruthersville
8.8 out of 10, Excellent, (460)
"Clean rooms and really comfortable beds!"
United States
Andrea
The price is ₹7,001
₹7,962 total
includes taxes & fees
5 Jan - 6 Jan 2026
The Farmstead Hotel
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (849)
"Very clean, great check in"
United States
Teresa
The price is ₹9,358
₹10,572 total
includes taxes & fees
7 Dec - 8 Dec
Fairfield Inn & Suites by Marriott Poplar Bluff
Terrace/patio
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is ₹8,782
₹9,833 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Poplar Bluff
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (439)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is ₹8,566
₹9,699 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Everything about this hotel was at or above our standards- very clean and comfortable. Pet friendly. Good breakfast. "
Erin 2-night trip
Posted 4 days ago
Drury Inn & Suites Cape Girardeau

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Frequently asked questions

How much do hotels with suites in Southeast Missouri cost?
You'll pay between ₹7,962 and ₹14,545 per night for hotels with suites in Southeast Missouri. Whatever your plans or budget, Expedia will help you find a home away from home with the spaciousness you're after. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best hotels with suites in Southeast Missouri?
Southeast Missouri offers multiple hotels with suites, with a total average guest review rating of 9.1. Planning a trip to Cape Girardeau? Put your bags down at Hampton Inn Cape Girardeau I 55 East, a popular 2.5-star city base with a dining venue and a terrace. Another recommended choice with suite rooms is Drury Plaza Hotel Cape Girardeau Conference Centre. It has a 3-star rating and amenities including a swimming pool and complimentary breakfast.
How many hotels with suites are there in Southeast Missouri?
Southeast Missouri has 9 hotels with suites to choose from. Enter your destination and travel dates and get a start on planning your perfect getaway today.
What are the best cheap hotels with suites in Southeast Missouri?
In Southeast Missouri, hotels with suites start from just ₹7,962 per night, which means you'll have plenty of cash left over for exploring. If Cape Girardeau is in your travel plans, check in at Hampton Inn Cape Girardeau I 55 East. As well as suite rooms, it comes with pool sun loungers and a terrace. Expedia also has inexpensive hotels with suites in Sikeston. Settle in at Pear Tree Inn Sikeston and take advantage of handy amenities including a swimming pool and front desk services. Discover Southeast Missouri on a shoestring by filling your sightseeing itinerary with fabulous free attractions. Hunter Valley Winery in Cape Girardeau is popular. If you're spending some time in Sikeston, you won't have to spend a cent when you visit Sikeston Depot Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels with suites in Southeast Missouri?
You'll find superb family-friendly hotels that offer this accommodation type in Southeast Missouri. If you're making tracks for Cape Girardeau, make a booking at Drury Plaza Hotel Cape Girardeau Conference Centre. With suites and useful amenities such as complimentary breakfast and housekeeping services, your entire crew will enjoy chilling out at this 3-star property. Drury Inn & Suites Cape Girardeau is also a top pick for families in Cape Girardeau. This 3-star option comes with complimentary breakfast, a laundry service and comfy suite rooms. Cape Girardeau offers plenty of family-friendly attractions when you're ready to head out and explore. Cape Splash Family Aquatic Centre and Lazy L Safari Park promise fun for the entire crew.
How can I find cheap hotels with suites in Southeast Missouri?
Expedia's filters will help you find a cheap hotel with suites in Southeast Missouri. First, set your nightly budget. Next, choose your preferred hotel star rating — the lower the rating, the more affordable the stay. You can also search for hotels in less popular neighbourhoods or ones that are located away from the centre. Like another tip? Join One Key™, our free travel rewards programme, to access our best prices.
Why book your hotel with suites in Southeast Missouri with Expedia?
Booking a hotel with suites in Southeast Missouri is as simple as deciding on your travel dates and selecting an option that suits you best. Seeking something low cost or luxurious, or a property that also has a particular amenity like a pool or spa? Expedia's filters make it a breeze to narrow down your search results and find your perfect match.
What is there to do in Southeast Missouri near my hotel with suites?
No matter your interests, there are so many things to put on your to-do list in Southeast Missouri. If you're holidaying in Cape Girardeau, check out Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site. Basing yourself in Ste Genevieve? Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site are among the best sights in this city.