TOP Business Hotels in Southeast Missouri, MO for 2026

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Our top choices for Southeast Missouri business-friendly hotels

Signature Double Room, 2 Queen Beds, Kitchenette | Bathroom | Combined shower/bathtub, free toiletries, hair dryer, towels

Luxury Suite, 1 Queen Bed with Sofa bed, Kitchen | Living area | Flat-screen TV

1. Shepherd Mountain Inn

Ironton

Katie

₹11,767

₹12,853 total

includes taxes & fees

28 Aug - 29 Aug

Standard Room, 2 Double Beds | Desk, iron/ironing board, free WiFi, bed sheets

2. Madison Inn Lodge

Fredericktown

Christine

₹8,352

₹9,123 total

includes taxes & fees

20 Aug - 21 Aug

Desk, laptop workspace, blackout curtains, iron/ironing board

3. Drury Inn & Suites Jackson MO

Jackson

Jamie

₹7,634

₹8,071 total

includes taxes & fees

23 Aug - 24 Aug

Standard Room, 1 King Bed, Jetted Tub, Golf View | Desk, blackout curtains, iron/ironing board, rollaway beds

4. Crown Pointe Lodge, BW Signature Collection

Farmington

Louise

₹9,734

₹10,596 total

includes taxes & fees

30 Aug - 31 Aug

5. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kellie

₹5,507

₹5,995 total

includes taxes & fees

31 Aug - 1 Sept

6. Holiday Inn Express & Suites Farmington by IHG

Farmington

Shawn

₹10,021

₹10,908 total

includes taxes & fees

23 Aug - 24 Aug

Room, 2 Queen Beds, Non Smoking | In-room safe, desk, blackout curtains, iron/ironing board

7. Super 8 by Wyndham Farmington

Farmington

Saundra

₹5,678

₹6,181 total

includes taxes & fees

30 Aug - 31 Aug

8. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Joy

₹9,543

₹10,765 total

includes taxes & fees

23 Aug - 24 Aug

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Top Southeast Missouri Hotel Reviews

Comfort Inn Festus - St Louis South

10/10 Excellent

"Clean room and relaxing 1-night stay"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Food was good, beautiful and functional lobby, nice friendly staff, room clean. Couldn’t ask for more."

Motel 6 Poplar Bluff, MO

8/10 Good

"Clean and nice."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"The breakfast was great."

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent

"The staff were very helpful. The room was in good shape."

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Excellent experience here. No complaints or concerns. Our travels in the next six weeks will include this hotel chain because of this experience!"

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Property was clean a room was stocked. Had microwave refrigerator and a stove refrigerator had working ice maker. Great room for the price"

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?

Rates for business hotels in Southeast Missouri range between ₹5,995 and ₹12,853 per night. No matter your budget, Expedia is here to help you find the perfect place to get the job done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

What are the best business-friendly hotels in Southeast Missouri?

Southeast Missouri has multiple business-friendly hotels with a total average guest review rating of 8.6. Attending a work-related event in Cape Girardeau? Hampton Inn Cape Girardeau I 55 East is a 2.5-stars stay that comes highly recommended by corporate travellers and includes a dining venue and a terrace. Another excellent choice for a business trip is Drury Plaza Hotel Cape Girardeau Conference Centre. Also in Cape Girardeau, it has a 3-stars rating and amenities such as a swimming pool and a restaurant.

How many business-friendly hotels are there in Southeast Missouri?

Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're meeting with new clients or working remotely, these stays come with the services and amenities you need to be productive.

What are the best cheap business-friendly hotels in Southeast Missouri?

When you're on the road for work in Southeast Missouri, Expedia will help you find the ideal business-friendly hotel. Hampton Inn Cape Girardeau I 55 East is a budget pick in Cape Girardeau. A dining venue and a swimming pool are some of its many amenities. Seeking affordable stays in Sikeston? Pear Tree Inn Sikeston is recommended by many corporate travellers. It offers conveniences that make it easy to both work and play, such as a swimming pool and a spa tub. Business-friendly hotels in Southeast Missouri start at just ₹5,995 a night. You'll find tons of fabulous and free attractions wherever you're off to in Southeast Missouri. If you're meeting with clients in Cape Girardeau, try to make time in your schedule for Hunter Valley Winery. You can also see the sights without spending a penny in Sikeston. Sikeston Depot Museum is one of the most popular free things to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

Are there any family-friendly hotels in Southeast Missouri that are also business friendly?

There sure are. Whether you're searching for a stay in Southeast Missouri with a conference room or a quiet space to work alone, con espacio para trabajar Expedia's got you sorted. Drury Plaza Hotel Cape Girardeau Conference Centre in Cape Girardeau is a fantastic choice. This 3-stars business and family-friendly option comes with all the necessary conveniences, like complimentary breakfast and housekeeping services. Pear Tree Inn Cape Girardeau West is another option in Cape Girardeau where corporate travellers can get some work done with the family in tow. Complimentary breakfast and a laundry service are among the many amenities at this 2.5-stars hotel. When you've finished work, it's time to discover Cape Girardeau with the kids. Popular family-friendly attractions include Cape Splash Family Aquatic Centre and Lazy L Safari Park.

Why book your business-friendly hotel in Southeast Missouri with Expedia?

Expedia is here to help you find an ideal business-friendly hotel when work takes you away from home. From meeting rooms and conference spaces to gyms and on-site restaurants, our stays have all the amenities you'll need to settle that big contract.

How can I find cheap business-friendly hotels in Southeast Missouri?

Select the "business friendly" filter, located under the "traveller experience" heading, to find cheap business-friendly hotels in Southeast Missouri. Then fine-tune your search by your per-night budget. Basing yourself outside the city centre is another easy way to save.

What is there to do in Southeast Missouri near my business-friendly hotel?

The most important accessory for your Southeast Missouri work visit is an epic itinerary for your downtime! Isle Casino Cape Girardeau, Show Me Centre and Riverfront Park are among the top sights if you're headed to Cape Girardeau. Sikeston is also home to terrific attractions, such as Sikeston Depot Museum, Central Park and The Book Bug.

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Book Business Hotels in Southeast Missouri on Expedia.com

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Change your mind

Treat yourself

Be picky

Check availability on Southeast Missouri Business Hotels

Our top choices for Southeast Missouri business-friendly hotels

1. Shepherd Mountain Inn

2. Madison Inn Lodge

3. Drury Inn & Suites Jackson MO

4. Crown Pointe Lodge, BW Signature Collection

5. Baymont Inn and Suites by Wyndham Farmington, MO

6. Holiday Inn Express & Suites Farmington by IHG

7. Super 8 by Wyndham Farmington

8. Drury Plaza Hotel Cape Girardeau Conference Center

9. Honeysuckle Inn - Mountain View

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Top Southeast Missouri Hotel Reviews

Comfort Inn Festus - St Louis South

Drury Inn & Suites Sikeston, MO

Motel 6 Poplar Bluff, MO

Drury Plaza Hotel Cape Girardeau Conference Center

Baymont Inn and Suites by Wyndham Farmington, MO

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Candlewood Suites Cape Girardeau by IHG

Frequently asked questions

Explore a world of travel with Expedia

Search Business Hotels in Southeast Missouri

Change your mind

Treat yourself

Be picky

Check availability on Southeast Missouri Business Hotels

Our top choices for Southeast Missouri business-friendly hotels

1. Shepherd Mountain Inn

2. Madison Inn Lodge

3. Drury Inn & Suites Jackson MO

4. Crown Pointe Lodge, BW Signature Collection

5. Baymont Inn and Suites by Wyndham Farmington, MO

6. Holiday Inn Express & Suites Farmington by IHG

7. Super 8 by Wyndham Farmington

8. Drury Plaza Hotel Cape Girardeau Conference Center

9. Honeysuckle Inn - Mountain View

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Top Southeast Missouri Hotel Reviews

Comfort Inn Festus - St Louis South

Drury Inn & Suites Sikeston, MO

Motel 6 Poplar Bluff, MO

Drury Plaza Hotel Cape Girardeau Conference Center

Baymont Inn and Suites by Wyndham Farmington, MO

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Candlewood Suites Cape Girardeau by IHG

Frequently asked questions

Explore a world of travel with Expedia