A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Search Business Hotels in Southeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Business Hotels

Tonight
7 Oct - 8 Oct
Tomorrow
8 Oct - 9 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Southeast Missouri business-friendly hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A building with a red awning labeled "Shepherd Mountain Inn."
A hotel room with two beds, a lamp, and a painting on the wall.
A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

1. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
₹11,874
₹12,970 total
includes taxes & fees
8 Oct - 9 Oct
Shepherd Mountain Inn
A motel with a covered entrance, a flag, and a phone number.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

2. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
₹7,809
₹8,529 total
includes taxes & fees
3 Nov - 4 Nov
Madison Inn Lodge
A hotel room with a bed, a sofa, a desk, and a chair.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.
A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

3. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
₹11,764
₹13,452 total
includes taxes & fees
11 Oct - 12 Oct
Holiday Inn Express & Suites Farmington by IHG
A modern kitchen with a coffee machine, a refrigerator, and a microwave.
A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.
A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.
A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

4. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
₹5,730
₹6,552 total
includes taxes & fees
18 Oct - 19 Oct
Super 8 by Wyndham Farmington
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

5. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
CURTIS
₹10,522
₹12,032 total
includes taxes & fees
11 Oct - 12 Oct
Crown Pointe Lodge, BW Signature Collection
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.
A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.
A reception area with a wooden counter, a coffee machine, and a display of pastries.
An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

6. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Nancy
₹9,741
₹11,004 total
includes taxes & fees
18 Oct - 19 Oct
Fairfield Inn & Suites by Marriott Poplar Bluff
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A hotel reception area with a glass partition, a reception desk, and a digital kiosk.
A gym with cardio equipment, a bench press, and a squat rack.
A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United Kingdom
Mark
₹5,246
₹5,998 total
includes taxes & fees
1 Nov - 2 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A hotel room with two beds, a brick wall, and a wooden headboard.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

8. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Debra S
₹7,703
₹8,144 total
includes taxes & fees
11 Oct - 12 Oct
Drury Inn & Suites Jackson MO
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

9. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
₹9,741
₹10,989 total
includes taxes & fees
15 Oct - 16 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

10. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Mary
₹9,629
₹10,863 total
includes taxes & fees
11 Oct - 12 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
View all properties

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"We love staying in this hotel when we are traveling through the area. The staff are great, the rooms are consistently clean and the beds are very comfortable. We enjoy the complementary wine that is served each evening as well. Breakfast is good too."
Tamara 1-night trip
Posted 6 hours ago
Drury Inn & Suites Sikeston, MO
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"Clean rooms, efficient staff, lovely breakfast. I appreciated the hotel sending a text after I checked in; it made it very easy to get questions answered."
Mary 1-night trip
Posted 7 hours ago
Hampton Inn Poplar Bluff
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Nice property"
Matthew 2-night trip
Posted 17 hours ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Wonderful. Very clean, spacious and lovely staff. Breakfast was delicious also."
Mary 2-night trip
Posted 19 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"Everything was good about the room except the bathroom. The stopper on the sink did not work and there was a dent in the wall. The face/wash towels need to be changed out. They are no longer white. They are dull in color. The couch needs to be cleaned and freshen. The staff was excellent and everything else is good. I just wish that breakfast offered hot eggs and meat vs. only waffles. Otherwise the room was good."
James 3-night trip
Posted 22 hours ago
Days Inn and Suites by Wyndham Sikeston
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

8/10 Good
"These stay was good. Breakfast was your average Hotel breakfast no complaints other than staff continually let the coffee run out every morning. Staff at front desk were conversing with what must have been someone they knew because of the colorful language they were using. Very unprofessional."
Glenn 2-night trip
Posted 2 days ago
Comfort Inn Festus - St Louis South
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"
Judith 1-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"Great place"
BRANDY 1-night trip
Posted 4 days ago
Super 8 by Wyndham Sikeston/Miner Area
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"The food & drinks were great & the staff was very friendly. Room was very nice."
Cynthia 1-night trip
Posted 4 days ago
Drury Inn & Suites Hayti Caruthersville

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Rates for business hotels in Southeast Missouri range between ₹5,998 and ₹13,452 per night. No matter your budget, Expedia is here to help you find the perfect place to get the job done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southeast Missouri?
Southeast Missouri has multiple business-friendly hotels with a total average guest review rating of 9.0. Attending a work-related event in Cape Girardeau? Hampton Inn Cape Girardeau I 55 East is a 2.5-stars stay that comes highly recommended by corporate travellers and includes a dining venue and a terrace. Another excellent choice for a business trip is Drury Plaza Hotel Cape Girardeau Conference Centre. Also in Cape Girardeau, it has a 3-stars rating and amenities such as a swimming pool and a restaurant.
How many business-friendly hotels are there in Southeast Missouri?
Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're meeting with new clients or working remotely, these stays come with the services and amenities you need to be productive.
What are the best cheap business-friendly hotels in Southeast Missouri?
When you're on the road for work in Southeast Missouri, Expedia will help you find the ideal business-friendly hotel. Hampton Inn Cape Girardeau I 55 East is a budget pick in Cape Girardeau. A dining venue and a swimming pool are some of its many amenities. Seeking affordable stays in Sikeston? Pear Tree Inn Sikeston is recommended by many corporate travellers. It offers conveniences that make it easy to both work and play, such as a swimming pool and a spa tub. Business-friendly hotels in Southeast Missouri start at just ₹5,998 a night. You'll find tons of fabulous and free attractions wherever you're off to in Southeast Missouri. If you're meeting with clients in Cape Girardeau, try to make time in your schedule for Hunter Valley Winery. You can also see the sights without spending a penny in Sikeston. Sikeston Depot Museum is one of the most popular free things to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southeast Missouri that are also business friendly?
There sure are. Whether you're searching for a stay in Southeast Missouri with a conference room or a quiet space to work alone, con espacio para trabajar Expedia's got you sorted. Drury Plaza Hotel Cape Girardeau Conference Centre in Cape Girardeau is a fantastic choice. This 3-stars business and family-friendly option comes with all the necessary conveniences, like complimentary breakfast and housekeeping services. Pear Tree Inn Cape Girardeau West is another option in Cape Girardeau where corporate travellers can get some work done with the family in tow. Complimentary breakfast and a laundry service are among the many amenities at this 2.5-stars hotel. When you've finished work, it's time to discover Cape Girardeau with the kids. Popular family-friendly attractions include Cape Splash Family Aquatic Centre and Lazy L Safari Park.
Why book your business-friendly hotel in Southeast Missouri with Expedia?
Expedia is here to help you find an ideal business-friendly hotel when work takes you away from home. From meeting rooms and conference spaces to gyms and on-site restaurants, our stays have all the amenities you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Southeast Missouri?
Select the "business friendly" filter, located under the "traveller experience" heading, to find cheap business-friendly hotels in Southeast Missouri. Then fine-tune your search by your per-night budget. Basing yourself outside the city centre is another easy way to save.
What is there to do in Southeast Missouri near my business-friendly hotel?
The most important accessory for your Southeast Missouri work visit is an epic itinerary for your downtime! Isle Casino Cape Girardeau, Show Me Centre and Riverfront Park are among the top sights if you're headed to Cape Girardeau. Sikeston is also home to terrific attractions, such as Sikeston Depot Museum, Central Park and The Book Bug.

Explore a world of travel with Expedia