TOP Spa Hotels in South San Diego, CA for 2026

A beach with a pier extending into the ocean, a person standing on the shore, and the sun setting over the water.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on South San Diego Spa Hotels

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for South San Diego hotels with a spa

Premium bedding, in-room safe, desk, laptop workspace

Daily cooked-to-order breakfast for a fee

Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, pool loungers

1. Best Western Plus Marina Gateway Hotel

National City

Indulge in bay-side spa services and hot tub relaxation at this tranquil hotel where pampering treatments meet scenic marina views.

₹14,496

₹15,973 total

includes taxes & fees

7 Sept - 8 Sept

2. Gaylord Pacific Resort & Convention Center

Chula Vista

Rejuvenate at this bayside retreat where daily spa treatments complement three outdoor pools and serene nature views.

₹23,919

₹31,558 total

includes taxes & fees

7 Sept - 8 Sept

Couples treatment room(s), sauna, hot tub, steam room, body treatments

3. Loews Coronado Bay Resort

Silver Strand

Discover a bayside retreat where waterfront bliss meets spa indulgence, offering 15 treatment rooms for total relaxation and rejuvenation.

₹23,064

₹30,301 total

includes taxes & fees

9 Sept - 10 Sept

4. Pier South Resort, Autograph Collection by Marriott

Imperial Beach

Oceanfront wellness retreat with daily spa treatments, beachfront dining, and private balconies offers a rejuvenating coastal escape.

₹22,585

₹28,463 total

includes taxes & fees

30 Aug - 31 Aug

5. Best Western Plus Island Palms Hotel & Marina

Point Loma

Blissful bay views and relaxing massages set the scene for a restorative escape at this waterfront sanctuary with bubbling hot tubs.

₹13,365

₹15,363 total

includes taxes & fees

7 Sept - 8 Sept

Hot stone massages, prenatal massages, sports massages, body scrubs

2 restaurants; breakfast, lunch and dinner served

6. San Diego Mission Bay Resort

Mission Bay

Unwind at this bay-view resort offering garden massages, poolside lounging, and a rejuvenating full-service spa retreat.

₹19,898

₹27,907 total

includes taxes & fees

8 Sept - 9 Sept

7. Humphreys Half Moon Inn

Point Loma

Escape to this bayfront sanctuary with deep-tissue massages, a serene hot tub, and an outdoor pool for complete relaxation.

₹18,011

₹22,609 total

includes taxes & fees

31 Aug - 1 Sept

8. Omni San Diego Hotel at the Ballpark

Downtown San Diego

Rooftop spa retreat delivers poolside massages and soothing therapies in the heart of city centre San Diego.

₹15,153

₹21,879 total

includes taxes & fees

7 Sept - 8 Sept

View all properties

Choose what matters most at spa hotels in South San Diego

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top South San Diego Hotel Reviews

Bahia Resort Hotel

8/10 Good

"Family friendly resort with private beach/bay"

The Dana on Mission Bay

10/10 Excellent

"Lovely"

Wyndham San Diego Bayside

10/10 Excellent

"Vehicle parking fee is too expensive. The view is very good"

California Suites Hotel

10/10 Excellent

"Great place for the price point. Clean, easy to get to and close to the beach as long as you drive. The blankets are thin so I would bring my own, and the mattress is a little wonky, but incredibly clean and well maintained. The pool is super nice and I would visit again."

Bay Club Hotel & Marina

8/10 Good

"Very nice place with economical pricing. The resort amenities are minimal, but adequate. Covered underground parking a bonus."

Manchester Grand Hyatt San Diego

10/10 Excellent

"Na"

Explore a world of travel with Expedia

Flights to San Diego

Book Spa Hotels in South San Diego on Expedia.com

Room 1

Change your mind

Treat yourself

Be picky

Check availability on South San Diego Spa Hotels

Our top choices for South San Diego hotels with a spa

1. Best Western Plus Marina Gateway Hotel