The Best Hotels in Santa Lucia, Syracuse - 2026 Updated Prices

A modern building with a unique triangular roof and a central spire.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Compare popular hotels in Santa Lucia

Property	Property class	Guest rating
Caportigia Boutique Hotel	5.0 star property	9.4 Exceptional 289 reviews	View
Fortuna Guest House	1.0 star property	9.2 Wonderful 19 reviews	View
Lakkios	3.0 star property	9.2 Wonderful 74 reviews	View
Hotel Palazzo Cavalieri	4.0 star property	9.0 Wonderful 43 reviews	View
Re Dionisio Luxury Suites	3.0 star property	8.8 Excellent 58 reviews	View

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.

A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Teatro dei Pupi or Cathedral of Syracuse.

See properties

Ancient ruins with a large amphitheater surrounded by trees.

Neapolis

While visiting Neapolis, you might make a stop by sights like Archaeological Park of Neapolis and Greek Theatre of Syracuse.

See properties

A natural rock arch over a body of water with people paddling in kayaks.

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

See properties

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

See properties

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

See properties

Top Santa Lucia Hotel Reviews

Fortaleza Charme House

10/10 Excellent

"This is a lovely hotel. It is a short walk over the bridges to Ortigia to all of the lovely things to see on the island. The rooms are really spacious and comfortable with everything you need including a little kitchen space if you want to eat in (although there are so many lovely restaurants nearby). Nicole and Francesco where wonderful. We had helpful information from both of them about our arrival and also some fantastic recommendations for places to eat. The hotel was peaceful and cool in the heat. It was a great place to stay."

Mangia's Brucoli, Sicily, Autograph Collection

10/10 Excellent

"We stayed here for 5 nights in a room with private pool. The room was of high standards, clean and elegant, and the pool and outdoor area perfect for relaxing in privacy. The property in general was beautiful and well maintained. Food was good and the breakfast buffet left little to wish for. The offer of paying €120 pp per day for lunch and dinner is not worth it, though, even though the restaurants are quite expensive. Overall a very nice stay and we highly recommend this hotel."

Grand Hotel Des Ètrangers - The Leading Hotels of the World

10/10 Excellent

"Beautiful hotel, breakfast spread was brilliant and room extremely clean. Staff were all so lovely and attentive. We had a great first afternoon at the pool bar and were very well looked after by a young man who went above and beyond - sorry we did not catch his name."

Hotel Parco delle Fontane

10/10 Excellent

"Very nice hotel outside of busy area but easy to access downtown Ortigia and Siracusa Unfortunately was only there for one night but pool looked wonderful and historic ambiance in hotel was interesting to see. Parking was free and breakfast was wonderful with so many options! Will definitely revisit when I’m the area again!"

Grande Albergo Alfeo

10/10 Excellent

"We stayed here for a few nights and had a great experience from start to finish. The room was very clean, the staff was welcoming and helpful whenever we needed anything, and the breakfast had plenty of fresh options each morning. The air conditioning worked flawlessly, which made the room especially comfortable after a long day of sightseeing. I'd definitely stay here again and would recommend it to anyone visiting the area."

Grand Hotel Villa Politi

10/10 Excellent

"The rooms are really nice, smaller than pictures, but nice. View was ok, small porthole in a Concrete wall. Pool was great, breakfast was amazing. Staff are very friendly and attentive. We had a car so it was 7 minute drive to parking outside Ortigia every evening plus we did day trips to Noto, Catania, Marzemeni, Brucoli. Parking was easy and convenient. Great value for the price. I would stay again. We rented a self captained boat as well, coast is beautiful, and we ate every night in Ortigia. We split our time between Syracusa-Ortigia and Taormina."

Frequently asked questions

What is Santa Lucia like?

Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.

Where is the best hotel for a stay in Santa Lucia?

Based on our traveller data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Caportigia Boutique Hotel and Fortaleza Charme House.

How many hotels will I find in Santa Lucia?

Expedia has 312 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.

What are the top things to see and do in Santa Lucia?

Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

Explore a world of travel with Expedia

Book Hotels in Santa Lucia on Expedia.it

Search Hotels in Santa Lucia, Syracuse

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Lucia hotels

1. Caportigia Boutique Hotel

2. Nostos rooms & Apartments

3. Grande Albergo Alfeo

4. Piccolo Hotel Casa Mia

5. B&B Nike

6. B&B L'INFIORESCENZA

7. Lakkios

8. Giuggiulena Villa

9. Regina Margherita

10. B&B Siracusa

11. Hotel Mediterraneo

12. Gymnasium

13. B&B IL MORO

14. Isonzo Suites

15. Populus

16. Hotel Palazzo Cavalieri

17. Melody rooms

18. Re Dionisio Luxury Suites

19. Calafatari B&B

20. Fortaleza Charme House

Compare popular hotels in Santa Lucia

Where to stay in Santa Lucia

Ortigia

Neapolis

Grottasanta

Acradina

Tiche

Top Santa Lucia Hotel Reviews

Fortaleza Charme House

Frequently asked questions

Explore a world of travel with Expedia