Search Gay-Friendly Hotels in Otay Mesa

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
9 Nov - 10 Nov
Tomorrow
10 Nov - 11 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

Our top choices for Otay Mesa LGBT-friendly hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,960 reviews)
"Good place to stay for work."
United States
Renato
The price is ₹13,523
₹15,383 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A hotel room with two beds, a television, a desk, and a dresser.

2. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
Chula Vista
8.6 out of 10, Excellent, (1,795 reviews)
"Clean room , friendly staff , always helpful, breakfast good , always great to return"
United States
Luis
The price is ₹9,739
₹10,713 total
includes taxes & fees
22 Nov - 23 Nov
La Quinta Inn by Wyndham San Diego Chula Vista
An outdoor patio with a fire feature, seating, and large windows.

3. Hampton Inn & Suites Imperial Beach San Diego

Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
Mar Vista
9.4 out of 10, Exceptional, (1,001 reviews)
"Great place to stay in imperial beach. Would stay here again."
United States
Joshua
The price is ₹13,890
₹15,861 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn & Suites Imperial Beach San Diego
A spacious lobby with a flat-screen TV, a fireplace, and comfortable seating areas.

4. Residence Inn by Marriott San Diego Chula Vista

Residence Inn by Marriott San Diego Chula Vista
3.0 star property
Otay Ranch
9.4 out of 10, Exceptional, (643 reviews)
"Wonderful accommodations, delicious breakfast, friendly staff, convenient location."
United States
Leslie
The price is ₹17,686
₹19,489 total
includes taxes & fees
30 Nov - 1 Dec
Residence Inn by Marriott San Diego Chula Vista
A compact hotel room with a kitchenette, a bed, a small seating area, and a window providing natural light.

5. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
Chula Vista
9.4 out of 10, Exceptional, (1,654 reviews)
"Great stay"
United States
Daniel
The price is ₹14,932
₹16,425 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express San Diego South - Chula Vista by IHG
A modern living room with a stone fireplace, sofas, a coffee table, and a view of the upper floor.

6. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
National City
9.2 out of 10, Wonderful, (4,230 reviews)
"Great property, friendly staff and a restaurant with good food and live music next door. Had an excellent time!"
United States
Candas
The price is ₹12,595
₹13,879 total
includes taxes & fees
29 Nov - 30 Nov
Best Western Plus Marina Gateway Hotel
A modern living room with large windows, a leather sofa, two armchairs, and a coffee table.

7. Days Inn by Wyndham Chula Vista/San Diego

Days Inn by Wyndham Chula Vista/San Diego
3.0 star property
Chula Vista
7.0 out of 10, Good, (1,321 reviews)
"Stayed here a few times and staff has always treated me well"
United States
Brian
The price is ₹8,030
₹8,849 total
includes taxes & fees
16 Nov - 17 Nov
Days Inn by Wyndham Chula Vista/San Diego
A hotel with a large swimming pool, multiple water slides, and a well-lit outdoor area with lounge chairs and umbrellas.

8. Gaylord Pacific Resort & Convention Center

Gaylord Pacific Resort & Convention Center
4.0 star property
Chula Vista
8.8 out of 10, Excellent, (703 reviews)
"I had a wonderful stay at the Gaylord! Everything was great, and I have no complaints. The restaurants were excellent, and having Starbucks downstairs was amazing—a perfect way to start the morning. I really enjoyed my visit and would happily stay again!"
United States
Joane
The price is ₹26,296
₹34,245 total
includes taxes & fees
29 Nov - 30 Nov
Gaylord Pacific Resort & Convention Center
A hotel lobby with a waterfall feature, outdoor seating area, and multiple floors with balconies.

9. Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
8.4 out of 10, Very good, (1,481 reviews)
"Had a good stay"
United States
Yesenia
The price is ₹11,082
₹12,772 total
includes taxes & fees
16 Nov - 17 Nov
Crowne Plaza San Diego - Mission Valley by IHG
A rooftop lounge with blue seating and a fire feature.

10. The Davis Downtown San Diego

The Davis Downtown San Diego
3.5 star property
Downtown San Diego
8.0 out of 10, Very good, (634 reviews)
"Great hotel! Easy to use! Great price and location!"
United States
Robert Scott
The price is ₹6,977
₹7,936 total
includes taxes & fees
26 Nov - 27 Nov
The Davis Downtown San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Otay Mesa

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
8.4
Very good
1,960 reviews
View
A hotel room with two beds, a television, a desk, and a dresser.
La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
8.6
Excellent
1,795 reviews
View
An outdoor patio with a fire feature, seating, and large windows.
Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
9.4
Exceptional
1,001 reviews
View
A spacious lobby with a flat-screen TV, a fireplace, and comfortable seating areas.
Residence Inn by Marriott San Diego Chula Vista
3.0 star property
9.4
Exceptional
643 reviews
View
A compact hotel room with a kitchenette, a bed, a small seating area, and a window providing natural light.
Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
9.4
Exceptional
1,654 reviews
View

Top Otay Mesa Hotel Reviews

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Otay Mesa

10/10 Excellent

Amazing very clean nice
United Kingdom
Umit
Reviewed August 3, 2025
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Frequently Asked Questions

How do I find gay-friendly accommodation in Otay Mesa?

Consider this your open invitation to pack your bags and find LGBTQ-friendly hotels in Otay Mesa on Expedia. People like Otay Mesa for its shopping and restaurants.

What is the top LGBTQ-friendly hotel in Otay Mesa?

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi.

What should I do while I'm visiting Otay Mesa?

During your trip, get out and enjoy everything Otay Mesa has to offer. You and your travelling companions may want to visit San Diego Zoo, San Ysidro Border Crossing and Petco Park. While you're here, capture some great memories of your trip with stops at Port of San Diego and Marine Corps Recruit Depot.

What is a gay-friendly hotel in Otay Mesa?

LGBTQ-friendly hotels, also known as gay-friendly hotels, welcome all travellers who identify as LGBTQIA+. We have worked with the International Gay and Lesbian Travel Association (IGLTA) to compile a selection of gay-friendly hotels worldwide. In Otay Mesa, hotels affiliated with IGLTA operate in a spirit of inclusiveness, prioritising a diverse environment in which guests are welcomed, respected and not obliged to declare or hide their sexual orientation.

What can I expect from a gay-friendly hotel in Otay Mesa?

Stay at a gay-friendly hotel in Otay Mesa and you won't have to hide or your sexuality or your gender identity when you check in. Some of Expedia's LGBTQ-friendly hotels go the extra mile and offer concierge services that provide information about nearby LGBTQ restaurants and local events.

Explore a world of travel with Expedia