The St Regis Bangkok offers 228 accommodations, which are accessible via exterior corridors and feature iPod docking stations and laptop-compatible safes. This individually furnished accommodation has separate sitting areas. Select Comfort beds feature Frette Italian sheets, down duvets and premium bedding. A pillow menu is available. 55-inch LED televisions come with digital channels. Full-sized fridge/freezers and espresso makers are provided. Bathrooms include a separate bath and shower with a deep soaking bath and a rainfall showerhead. Bathrooms are also outfitted with dressing gowns, slippers and complimentary toiletries.

Guests can surf the web using complimentary wired and wireless Internet access. Business-friendly amenities include desks and complimentary newspapers, as well as telephones; free local calls are provided (restrictions may apply). Additionally, rooms include complimentary bottles of water and a hairdryer. A nightly turndown service is provided and housekeeping is offered on a daily basis. Amenities available on request include hypo-allergenic bedding.

Clinique La Prairie Spa has 16 treatment rooms, including rooms for couples. Services include deep-tissue massages, hot stone massages, Thai massages and facials. A variety of treatment therapies are provided, including aromatherapy and reflexology. The spa is equipped with a spa tub, a steam room and Turkish bath/hammam.

The spa is open daily.