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Top Pet-friendly Southeast Missouri Hotels

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their ...

8/10 Very Good! (1,007 reviews)

This was our third stay at this Motel 6. It’s a great hotel with friendly staff, clean rooms and good location. Pets stay free!

Reviewed on 9 Mar 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32 Ste Genevieve MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (626 reviews)

Booked a queen 2 bed with accessibility. Checked in, got to a room that had one queen bed and a shower over the tub! I was told they could not see what I booked, nothing they could do!I guess since a room is booked for two people it is ok to have to sleep together! Not if your just traveling together! ...

Reviewed on 9 Mar 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd Festus MO

3 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Festus. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...

8/10 Very Good! (923 reviews)

The room was the cleanest that I have ever stayed in, in my life, totally spotless! The breakfast was very good, with alot of choices available!

Reviewed on 7 Mar 2026

See all 626 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.