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Top Adventure Southeast Missouri Hotels

Hampton Inn Farmington

850 Valley Creek Dr Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this hotel in Farmington. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

8.8/10 Excellent! (551 reviews)

My mattress was broke and they didn't fix it. I asked for a replacement or to be switched to a diffrent room. They said they didn't have one available. I then got back to my room the second night and they texted me at 11:48 and said they could swith rooms after I was already asleep in the floor for ...

Reviewed on 1 May 2026

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd Farmington MO

2 hours drive from Mark Twain National Forest

Stay at this golf hotel in Farmington. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...

9/10 Wonderful! (619 reviews)

Clean and nice staff

Reviewed on 6 May 2026

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Stay at this business-friendly hotel in Eminence. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Popular attractions Echo Bluff State Park and Current ...

9.4/10 Exceptional! (249 reviews)

Property was clean, quiet and beautiful. The restaurant is not worth it what so ever. 18$ nachos with 3 little chunks of chicken and a couple pieces of jalepeno. We decided after that to not order entrees. Our room was clean and very cozy. Staff was extremely nice.

Reviewed on 9 May 2026

See all 664 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.