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Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

₹7,961 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel lobby with a long reception desk, bar area with stools, seating with patterned cushions, and a large window offering a view of greenery.

2. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

Deborah

₹10,875 total

includes taxes & fees

28 Nov - 29 Nov

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

3. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Shirleen

₹10,916 total

includes taxes & fees

25 Nov - 26 Nov

A modern hotel lobby with a fireplace, comfortable seating, and a large window.

4. Hampton Inn & Suites Greenville Airport, SC

Greenville

Freda

₹10,528 total

includes taxes & fees

29 Nov - 30 Nov

A modern kitchen with a central island, bar stools, and pendant lighting.

5. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

Melinda

₹11,141 total

includes taxes & fees

27 Nov - 28 Nov

A dining area with a wooden table, chairs, and a vase of white flowers.

6. Hotel Hartness

Greenville

Nicole

₹20,876 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with sofas, a fire pit, and string lights.

7. Tru by Hilton Spartanburg

Spartanburg

Volodymyr

₹11,172 total

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a reception desk, green seating area, and multiple tables and chairs.

8. Home2 Suites by Hilton Duncan

Duncan

Marina

₹12,938 total

includes taxes & fees

29 Nov - 30 Nov

A hotel patio with outdoor seating, stone pillars, and a modern building in the background.

9. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jamie

₹11,997 total

includes taxes & fees

24 Nov - 25 Nov

A rooftop bar with seating, a bar area, and a view of the cityscape at dusk.

10. AC Hotel by Marriott Spartanburg

Spartanburg

Willow

₹15,750 total

includes taxes & fees

28 Nov - 29 Nov

A multi-story hotel with a central courtyard, a pool, and a parking area.

11. Comfort Suites Greenville Airport

Greenville

Azalia

₹9,583 total

includes taxes & fees

29 Nov - 30 Nov

A modern lobby with a reception desk, seating area, and a television screen.

12. Best Western Spartanburg I-26

Spartanburg

Santhosh

₹9,794 total

includes taxes & fees

8 Nov - 9 Nov

13. Clarion Inn

Greenville

Johnny

₹7,650 total

includes taxes & fees

29 Nov - 30 Nov

A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.

14. Comfort Suites At WestGate Mall

Spartanburg

Willie

₹9,256 total

includes taxes & fees

29 Nov - 30 Nov

A modern interior with a fireplace, seating, and a wooden accent wall.

15. Hampton Inn & Suites Greenville/Spartanburg I-85, SC

Duncan

Nilda

₹10,602 total

includes taxes & fees

16 Nov - 17 Nov

A spacious lobby with a bar area, seating, and large windows.

16. Hilton Garden Inn Spartanburg

Spartanburg

Patrick

₹10,692 total

includes taxes & fees

29 Nov - 30 Nov

A modern living room with a fireplace, a flat-screen TV, and a dining area with chairs and a table.

17. Fairfield Inn & Suites by Marriott Greenville Spartanburg/Duncan

Duncan

Jean

₹12,315 total

includes taxes & fees

23 Nov - 24 Nov

A multi-level hotel lobby with seating areas, a fireplace, and a staircase.

18. Four Points by Sheraton Spartanburg

Spartanburg

Derrick

₹13,224 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

19. Drury Inn & Suites Greenville

Greenville

Jamie

₹12,031 total

includes taxes & fees

9 Nov - 10 Nov

An indoor swimming pool with multiple lanes, lounge chairs, and a clear view of the sky through large windows.

20. Holiday Inn Express & Suites Greenville-Spartanburg (Duncan) by IHG

Duncan

Dawn

₹9,642 total

includes taxes & fees

29 Nov - 30 Nov

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Holiday Rentals in Upstate South Carolina

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"The kitchen was nice and came with basic utensils which was helpful"

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location, convenient!"

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"My wife and I enjoyed our stay here. 10/10 experience."

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

A modern kitchen with blue cabinets, a central island, and a spiral staircase leading to an upper level.

Greenwood Getaway w/ Furnished Patio & Lake View

Greenwood

"wonderful hosts, pet friendly, very clean"

Apartment

A swimming pool with a view of a lake and docked boats.

Lake Keowee Condo: Resort Pools & Lake Access!

Salem

"Wow!! Absolutely beautiful property. Recent remodel with beautiful and very tasteful design. Amazingly clean, organized and tidy. We are from Denver and did not have exposure to Lake Keowee. The lake was beautiful with great walking trails on the property. Special and spectacular spot! We will definitely go back. This is a gated community. Super comfortable king beds and nice linens."

Cottage

A spacious living room with a large sofa, a kitchen area with a bar, and a view of the outdoors through the windows.

Waterfront Cabin w/ Private Dock on Lake Hartwell!

Townville

"We booked last minute for Clemson parents weekend. It worked out fine, it is really in the middle of no where. There are no outlets in the bathroom you have to use the kitchen mirror and outlets to get ready. There was a coffee machine but no coffee. It was very clean. The deck needs some work."

Cottage

Mountain Rest Cottage w/ Gas Fireplace!

Mountain Rest

"Unit is attached to the owners house. The drive way leading up to the apartment is loose gravel. Not safe for a heavy motorcycle. "

Cottage

A covered porch with wooden railings and a table with chairs.

Fish, Hike & Explore! Family Tamassee Getaway

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

Cottage

A balcony with wicker chairs, a white railing, and a view of a forest.

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

See all holiday rentals

Hotels recommended for families in Upstate South Carolina

Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

₹10,875 total

includes taxes & fees

28 Nov - 29 Nov

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

See all hotels in Upstate South Carolina

A multi-tiered waterfall cascading over rocks in a forested area.

Top Upstate South Carolina Hotel Reviews

Comfort Inn Greenville - Haywood Mall

10/10 Excellent

"Plenty of restaurants nearby...easy access to I85. We had a little trouble finding the hotel entrance (hotel sits back from main road). Otherwise very pleasant and helpful staff."