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Our top choices for Upstate South Carolina hotels

Bed & breakfast

1. Tru by Hilton Spartanburg

Spartanburg

Jeremy

₹10,363 total

includes taxes & fees

30 Aug - 31 Aug

3 restaurants; breakfast and dinner served

2. AC Hotel by Marriott Spartanburg

Spartanburg

shannon

₹15,824 total

includes taxes & fees

16 Aug - 17 Aug

3. Comfort Suites At WestGate Mall

Spartanburg

Kristina

₹10,113 total

includes taxes & fees

22 Aug - 23 Aug

4. Hampton Inn Greer Greenville, SC

Greer

Teresa

₹14,491 total

includes taxes & fees

15 Aug - 16 Aug

5. Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

Michael

₹9,655 total

includes taxes & fees

16 Aug - 17 Aug

6. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Robin

₹10,515 total

includes taxes & fees

5 Aug - 6 Aug

7. Best Western Spartanburg I-26

Spartanburg

Francisco

₹9,836 total

includes taxes & fees

26 Aug - 27 Aug

8. Comfort Suites Greenville Airport

Greenville

Chandler

₹10,654 total

includes taxes & fees

30 Aug - 31 Aug

9. Four Points by Sheraton Spartanburg

Spartanburg

Susan

₹12,638 total

includes taxes & fees

9 Aug - 10 Aug

10. Hilton Garden Inn Spartanburg

Spartanburg

Stan

₹12,540 total

includes taxes & fees

16 Aug - 17 Aug

11. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

Chris

₹11,670 total

includes taxes & fees

23 Aug - 24 Aug

12. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Angela

₹10,270 total

includes taxes & fees

16 Aug - 17 Aug

13. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

Skylyn

₹11,258 total

includes taxes & fees

30 Aug - 31 Aug

14. Hampton Inn & Suites Greenville Airport, SC

Greenville

Kristina

₹11,948 total

includes taxes & fees

14 Aug - 15 Aug

15. Courtyard by Marriott Greenville Mauldin

Greenville

sarah

₹11,468 total

includes taxes & fees

9 Aug - 10 Aug

16. Wingate by Wyndham - Greenville-Airport

Greenville

Meridy

₹8,427 total

includes taxes & fees

3 Aug - 4 Aug

17. Best Western Plus Spartanburg

Spartanburg

Jane

₹10,136 total

includes taxes & fees

19 Aug - 20 Aug

18. Comfort Inn & Suites Greer - Greenville

Greer

Sally

₹10,802 total

includes taxes & fees

30 Aug - 31 Aug

19. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

₹8,854 total

includes taxes & fees

2 Aug - 3 Aug

20. Drury Inn & Suites Greenville

Greenville

Mark

₹12,102 total

includes taxes & fees

12 Aug - 13 Aug

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Holiday Rentals in Upstate South Carolina

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"Very good check in instructions. Very roomy and very quiet. Much more relaxing than a hotel room. Worth every penny."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Aparthotel

Coffee/tea maker, full-sized fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Aparthotel

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"We had a great time, very close to eating and shopping. The amenities were very helpful and we felt the area was very safe. We had an issue with getting a ticket even though we paid for parking but it was taken care of within an hour!"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Greer

"Very cute home close to everything. Super clean and spacious. Well furnished."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.

See properties

Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Martin Farm and Discovery Island Water Park.

See all hotels in Upstate South Carolina

A multi-tiered waterfall cascading over rocks in a forested area.

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"The front desk lady was so sweet and helpful i think her name was rose"

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"I ended up staying for an extra night because my flight was delayed. Both staff that checked me in each time were top notch. Very professional and polite. Asked us about our trip and thanked us for staying there. Best service I could ever expect. Thank you."