A bench, a bicycle, and a lake surrounded by trees.

Search Luxury Hotels in Upstate South Carolina

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina Luxury Hotels

Tonight
1 Oct - 2 Oct
Tomorrow
2 Oct - 3 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Upstate South Carolina luxury hotels

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.

1. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
₹16,623
₹18,452 total
includes taxes & fees
1 Nov - 2 Nov
The Shepherd Hotel Downtown Clemson
A white, two-story house with a front porch, surrounded by trees and shrubs.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.
A dining area with round tables, black chairs, and white tablecloths.
A bedroom with two beds, a TV, and a fireplace.

2. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
₹10,933
₹12,135 total
includes taxes & fees
27 Oct - 28 Oct
Liberty Hall Bed and Breakfast
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

3. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
₹14,512
₹16,108 total
includes taxes & fees
19 Oct - 20 Oct
The Abernathy of Clemson
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.

4. Hotel Domestique

Hotel Domestique
Travelers Rest
₹40,152
₹44,167 total
includes taxes & fees
4 Oct - 5 Oct
Hotel Domestique
Exterior
Dining
Interior
Interior

5. Bed & Breakfast on Tiffany Hill

Bed & Breakfast on Tiffany Hill
Mills River
₹31,048
₹35,007 total
includes taxes & fees
2 Oct - 3 Oct
Bed & Breakfast on Tiffany Hill
A bedroom with a bed, a sofa, a dresser, and a ceiling fan.
A dining room with a wooden table and chairs, a sofa, and a view of the outdoors.
A porch with two wicker chairs and a small table, a green door, and a window with a view of the backyard.
A two-story house with a front porch, a driveway, and a well-maintained lawn.

6. Opal and West House

Opal and West House
Shelby
₹17,764
₹20,029 total
includes taxes & fees
21 Oct - 22 Oct
Opal and West House
View all properties

Top Upstate South Carolina Hotel Reviews

Explore a world of travel with Expedia