All Hotels by Best Western in Upstate South Carolina - 2026 Updated Prices | Expedia

A bench, a bicycle, and a lake surrounded by trees.

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Our top choices for Upstate South Carolina Best Western

A modern lobby with a reception desk, seating area, and a television screen.

A hotel room with two beds, a desk with a lamp, a chair, a patterned rug, and a large window.

A hotel with a covered entrance, brick exterior, and a sign indicating it is a Best Western hotel.

A swimming pool with lounge chairs and tables, surrounded by brick buildings and a covered seating area.

1. Best Western Spartanburg I-26

Spartanburg

United States

Santhosh

₹9,693

₹10,759 total

includes taxes & fees

8 Oct - 9 Oct

A modern living room with a fireplace, two sofas, and a coffee table.

A modern gym with various exercise equipment, motivational wall graphics, and a large window offering a view of the outdoors.

A hotel room with two beds, a desk, a TV, and a window with curtains.

A reception area with two wooden reception desks, a blue accent wall, and a mounted television.

2. Best Western Spartanburg Northwest

Spartanburg

United States

Muhammad Awais

₹8,878

₹10,052 total

includes taxes & fees

1 Nov - 2 Nov

A fire pit with a bench on a concrete patio, surrounded by trees and a view of a body of water.

A Best Western hotel with a modern design, multiple flags, and well-lit signage.

A reception area with a stone wall, wooden reception desk, and a potted plant.

A hotel room with two beds, a desk, a chair, a desk lamp, a bathroom with a mirror, and a window with curtains.

3. Best Western Travelers Rest Greenville

Travelers Rest

United States

Gennaro

₹9,275

₹10,203 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

4. Best Western Seneca-Clemson

Seneca

United States

Michelle

₹8,961

₹9,857 total

includes taxes & fees

28 Oct - 29 Oct

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Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"Very nice stay and conviennent"

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

10/10 Excellent

"Really a great stay ."

Lakeside Lodge Clemson

Lakeside Lodge Clemson

10/10 Excellent

"My first time here. Lovely resort. Pool was awesome. Poolside restaurant had good sandwiches. I wish the breakfast was open before 10:00 am, but the free coffee was nice. I walked to Starbucks for breakfast. Room was spacious."

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

10/10 Excellent

"clean room"

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent

"The room was very clean and comfortable. Staff was helpful and friendly. The lobby is to die for with the displays of Native American art and jewelry. A fun place e to stay with convenient location."

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

8/10 Good

"Great stay. Clean and conveniently located."

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