Search Hotels in South Central Houston, Houston

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Our top choices for South Central Houston hotels

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1740)
"Loved the room, clean, friendly staff. Would reccomend :)"
United States
Rolando
The price is ₹7,988
₹9,451 total
includes taxes & fees
22 Dec - 23 Dec
Hilton Houston Plaza/Medical Center

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
7.8 out of 10, Good, (34)
"Clean room and amenities. The grounds are clean as well. There is free parking available for one car."
United States
Erika
The price is ₹7,435
₹8,700 total
includes taxes & fees
20 Dec - 21 Dec
Downtowner Inns - Houston Downtown

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (472)
"Solid hotel and amenities"
United States
Kenneth
The price is ₹9,176
₹10,736 total
includes taxes & fees
8 Jan - 9 Jan 2026
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1003)
"Comfortable bed, very clean, very good food, quite, friendly stuff and hotel shuttle works easy."
United States
Elena
The price is ₹12,932
₹18,008 total
includes taxes & fees
9 Jan - 10 Jan 2026
Houston Marriott Medical Center/Museum District

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1002)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is ₹13,264
₹17,326 total
includes taxes & fees
18 Dec - 19 Dec
InterContinental Houston by IHG

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1005)
"Clean room close to food, coffee and hospitals. "
United States
Patrick
The price is ₹12,319
₹15,333 total
includes taxes & fees
20 Dec - 21 Dec
The Westin Houston Medical Center/Museum District

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1001)
"Nice hotel"
United States
Robert Jeanmard
The price is ₹7,501
₹8,776 total
includes taxes & fees
13 Dec - 14 Dec
Americas Best Value Inn Medical Center Downtown

Luxurious 3 Bed3 Bath Near Downtown Houston

Luxurious 3 Bed3 Bath Near Downtown Houston
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1)
"This was made for a perfect family vacation… super clean kid friendly with an awesome view of Houston for the adults on rooftop "
United States
Ebony
The price is ₹8,647
₹30,671 total
includes taxes & fees
15 Dec - 16 Dec
Luxurious 3 Bed3 Bath Near Downtown Houston

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1844)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
2.0 star property
South Central Houston
9.8 out of 10, Exceptional, (57)
"Great location will stay again "
United States
Jason
The price is ₹10,121
₹11,842 total
includes taxes & fees
16 Dec - 17 Dec
Wanderstay Boutique Hotel

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (885)
"Nice place to stay"
United States
Alexandra
The price is ₹13,205
₹15,449 total
includes taxes & fees
20 Dec - 21 Dec
Hilton University of Houston

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (542)
"great neighborhood, friendly staff, and delicious breakfast"
United States
Anna
The price is ₹14,816
₹17,334 total
includes taxes & fees
8 Jan - 9 Jan 2026
La Maison in Midtown an urban B&B

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (201)
" Beautiful relaxing love this place best I seen thank you"
United States
James
The price is ₹18,622
₹23,137 total
includes taxes & fees
30 Dec - 31 Dec
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
3.0 star property
South Central Houston
The price is ₹19,192
₹53,666 total
includes taxes & fees
20 Dec - 21 Dec
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home

Modern Cozy Home with King Bed

Modern Cozy Home with King Bed
3.5 star property
South Central Houston
9.4 out of 10, Exceptional, (22)
"Very spacious and close to just about everything. The view is amazing too"
United States
Brenden
The price is ₹12,200
₹31,443 total
includes taxes & fees
6 Jan - 7 Jan 2026
Modern Cozy Home with King Bed

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (226)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is ₹4,858
₹5,684 total
includes taxes & fees
21 Dec - 22 Dec
Southmore Boulevard Motel

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1001)
"Room was very large…"
United States
Veronica
The price is ₹6,800
₹7,983 total
includes taxes & fees
16 Dec - 17 Dec
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Perfect Houston Group Stay for 12 With 6 Beds 6 Baths

Perfect Houston Group Stay for 12 With 6 Beds 6 Baths
2.0 star property
South Central Houston
The price is ₹27,568
₹73,363 total
includes taxes & fees
16 Dec - 17 Dec
Perfect Houston Group Stay for 12 With 6 Beds 6 Baths

Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.4 out of 10, Very good, (188)
"This is an amazing place to stay."
United States
Darius
The price is ₹5,166
₹6,045 total
includes taxes & fees
20 Dec - 21 Dec
Wanderstay Houston Hostel

The Green Haus Luxxe Cabana Rooftop Retreat

The Green Haus Luxxe Cabana Rooftop Retreat
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (1)
The price is ₹26,347
₹61,657 total
includes taxes & fees
18 Dec - 19 Dec
The Green Haus Luxxe Cabana Rooftop Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Top South Central Houston Hotel Reviews

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Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit Midtown Arts and Theater Center Houston and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, La Maison in Midtown an urban B&B is the highest ranked property in South Central Houston. This B&B is a short 4-minute walk from Westheimer Road, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Wanderstay Boutique Hotel and MyCrib Houston Hostel.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1150 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and James Turrell's Twilight Epiphany Skyscape. Midtown Arts and Theater Center Houston and Children's Museum of Houston are some other stops worth a visit in the neighbourhood. Toyota Center, Shape Community Center and Project Row Houses are just a few of the places to visit in and around South Central Houston. H&PE Arena and Eldorado Ballroom are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station.