Photo by Ryan Coleman

Search Luxury Hotels in Sikeston

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Sikeston Luxury Hotels

Tonight
7 Dec - 8 Dec
Tomorrow
8 Dec - 9 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Top Sikeston Luxury Hotels

1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
"A great stay in every aspect. "
United States
Gertrude
The price is ₹5,661
₹6,452 total
includes taxes & fees
14 Dec - 15 Dec
Days Inn and Suites by Wyndham Sikeston
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"I liked how comfortable the beds and pillows were."
United States
Christine
The price is ₹6,299
₹7,106 total
includes taxes & fees
11 Dec - 12 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Quality Inn

Quality Inn

2.5 star property
Cape Girardeau
7.2 out of 10, Good, (680)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is ₹5,423
₹6,118 total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Clean room, great location and friendly staff"
United States
Mark
The price is ₹8,098
₹9,311 total
includes taxes & fees
11 Dec - 12 Dec
Drury Inn & Suites Sikeston, MO
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1001)
"I do love this hotel chain. Another great visit!"
United States
Mark
The price is ₹8,098
₹9,135 total
includes taxes & fees
11 Dec - 12 Dec
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sikeston Hotel Reviews

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent
"Very nice staff and very clean"
Jacquelyn 1-night trip
Posted 3 days ago
Pear Tree Inn Cape Girardeau Near the Medical Center

Explore a world of travel with Expedia

Frequently asked questions

Are you looking for a luxury hotel for your stay in Sikeston?
Use Expedia and let us help you arrange a flight to Cairo, IL (CIR-Cairo Regional) airport or Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Sikeston has to offer. During your visit, you might want to enjoy the shopping which Sikeston is known for.
When can I expect good weather in Sikeston?
Planning for the weather is a good way to make your trip to Sikeston relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Sikeston is 1536 mm.
What's there to see and do in Sikeston?
Experience all that Sikeston has to offer when you visit Central Park, Sikeston Depot Museum and Front Street Studio & Art Gallery. If you have a little extra time during your trip, you might want to make a stop at Stoddard County Civil War Memorial Cemetery and Hunter-Dawson State Historic Site.