A person in a red jacket and black boots standing on a sandy beach, a dog walking beside them, and another person paddling a kayak in calm water.

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Check availability on Salem Spa Hotels

Tonight
17 Sept - 18 Sept
Tomorrow
18 Sept - 19 Sept
This weekend
18 Sept - 20 Sept
Next weekend
25 Sept - 27 Sept

Our top choices for Salem hotels with a spa

1. Greystone Inn

Greystone Inn
Lake Toxaway
  • Soak in mountain views at this lakeside retreat with couples' spa treatment rooms, yoga classes, and deep-tissue massages.
₹38,287
₹46,002 total
includes taxes & fees
27 Sept - 28 Sept
Greystone Inn
View all properties

Choose what matters most at spa hotels in Salem

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Salem Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Friendly and convenient hotel that I keep returning to every year for business travel."
John 1-night trip
Posted 3 days ago
Hampton Inn & Suites Seneca-Clemson Area
Courtyard Marriott Clemson

Courtyard Marriott Clemson

10/10 Excellent
"Nice environment and the people was outstanding"
Carey 1-night trip
Posted 3 days ago
Courtyard Marriott Clemson
The Skyline Lodge

The Skyline Lodge

8/10 Good
"PROS: The hotel is very peaceful as it is located in the middle of the mountain. The rooms are clean, nice and comfortable. Employees are nice as well. CONS: the hotel only has two floors. We stayed on the first floor and we could hear the footsteps of the people staying above us because the walls and floors are extremely thin. Also, there is no elevator so take this into consideration if you can’t lift your luggage up and down the stairs."
Claudia 2-night trip
Posted 4 days ago
The Skyline Lodge
Hampton Inn & Suites Cashiers Sapphire Valley

Hampton Inn & Suites Cashiers Sapphire Valley

10/10 Excellent
"Far and away the nicest Hampton Inn I have ever been in. Being close to the Highlands is definitely a plus the room was very nice and was equipped with a microwave and as a refrigerator. Modern design with a very nice bathroom. They have a regular elaborate morning breakfast that I think goes till 10 but I did not partake 24 hour coffee station and small things of that nature are helpful. It’s a very nice property and you don’t feel like you’re at a chain hotel."
Susan 1-night trip
Posted 4 days ago
Hampton Inn & Suites Cashiers Sapphire Valley
Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

8/10 Good
"The property is very new and quite clean. There is a lovely common area where you can sit and relax. Staff was very helpful with our questions"
Christine 2-night trip
Posted 6 days ago
Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

Frequently asked questions

Looking to holiday at a spa hotel in Salem?
Treat yourself to some pampering and book a hotel with a spa. Immerse yourself in nature at the lakeside setting and waterfalls in Salem. Make sure you enjoy activities such as wakeboarding and golf during your stay. Spa hotels are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Salem?
Take in the sights and attractions that Salem offers with a visit to Devils Fork Lake Jocassee, Devils Fork State Park and Keowee Key Golf Course. If you have a bit of extra time while you're in the area, you might want to check out Lake Keowee and Lake Jocassee.
What is a Salem spa hotel?
Spa hotels in Salem feature on-site spas offering services such as massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation and relaxation.

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