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Check availability on Salem Luxury Hotels

Our top choices for Salem luxury hotels

In-room safe, blackout curtains, soundproofing, iron/ironing board
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (743)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is ₹15,027
₹16,680 total
includes taxes & fees
22 Dec - 23 Dec
The Shepherd Hotel Downtown Clemson
Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (557)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Restaurant
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
The price is ₹11,070
₹16,825 total
includes taxes & fees
20 Dec - 21 Dec
Liberty Hall Bed and Breakfast
Breakfast, lunch and dinner served
Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

Trailborn Highlands, Outdoor Collection by Marriott Bonvoy
4.0 star property
Highlands
9.2 out of 10, Wonderful, (254)
"Clean.great staff.easy access Close to downtown shopping and restaurants.very nice atmosphere.We had a relaxing stay."
United States
Stephen
The price is ₹13,519
₹14,837 total
includes taxes & fees
22 Dec - 23 Dec
Trailborn Highlands, Outdoor Collection by Marriott Bonvoy
Signature House, 4 Bedrooms, Patio | Living room | 43-inch Smart TV with cable channels, TV, fireplace
Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson
4.0 star property
Anderson
The price is ₹12,107
₹28,596 total
includes taxes & fees
1 Jan - 2 Jan 2026
Lake Hartwell Frank Howard Home Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Salem Hotel Reviews

Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Friendly staff. Great location. Large rooms. "
Jennifer 2-night trip
Posted 10 days ago
Trailborn Highlands, Outdoor Collection by Marriott Bonvoy
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

10/10 Excellent
"Property, room, and front desk were all very nice. Safety strips in the bathtub would be my only suggestion. "
Norma 1-night trip
Posted 3 weeks ago
Quality Inn Seneca Clemson Area US-123

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Frequently asked questions

Are you looking for a luxury hotel for your Salem holiday?
Expedia can help you arrange a flight to Greenville, SC (GSP-Greenville-Spartanburg Intl.) airport, and then you can select from various places to stay that will deliver the luxury you'd like to find. Amenities are an important consideration when you plan a trip, so we make it easy to get what you want to make your stay special. If you want a posh hotel with fine dining, a spa or several swimming pools, Expedia can help you find the best luxury hotel experience that Salem offers. Salem has some interesting things to see and do including Devils Fork State Park and Keowee Key Golf Course, so you might want to take in the local sights during your visit.
When can I expect good weather in Salem?
Planning for the weather is an important factor for making your trip to Salem a success, especially when you're splurging. The hottest months are usually July and August, with an average temperature of 20°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Salem is 1754 mm.
What's there to see and do in Salem?
Enjoy all that Salem has to offer and visit Devils Fork State Park, Keowee Key Golf Course and Lake Keowee. If you have a little extra time during your trip, you might want to check out Lake Jocassee and Nantahala National Forest.