Search Hotels in South Main, Houston

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near South Main, Houston

Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.2 out of 10, Good, (1172)
"Everyone was very pleasant, I will be returning."
United States
Amy
The price is ₹8,705
₹10,185 total
includes taxes & fees
23 Oct - 24 Oct
Wyndham Houston near NRG Park/Medical Center
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6 out of 10, (1001)
"The rooms were clean, the beds were soft, the staff was friendly. The breakfast wasnt bad either. It was literally the best bang for our buck. "
United States
Carolina
The price is ₹5,489
₹6,422 total
includes taxes & fees
17 Nov - 18 Nov
Quality Inn & Suites NRG Park - Medical Center
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6 out of 10, (948)
"Great place to stay, Breakfast not so fulfilling but good service and clean rooms."
United States
ALBERTO
The price is ₹6,947
₹8,128 total
includes taxes & fees
27 Oct - 28 Oct
Wingate Houston near NRG Park/Medical Center
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4 out of 10, Good, (804)
"The staff is great. The area is questionable due to homeless population."
United States
Bryana
The price is ₹6,507
₹7,613 total
includes taxes & fees
27 Oct - 28 Oct
Candlewood Suites Houston Medical Center by IHG
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6 out of 10, Excellent, (997)
"Loved staying at the Comfort Suites ."
United States
Linda
The price is ₹7,043
₹8,241 total
includes taxes & fees
17 Nov - 18 Nov
Comfort Suites Houston near Medical Center- NRG Stadium
Hyatt Place Houston Medical Center
3.0 star property
9.2 out of 10, Wonderful, (2050)
"Great place to stay!"
United States
Jason
The price is ₹11,884
₹13,978 total
includes taxes & fees
3 Nov - 4 Nov
Hyatt Place Houston Medical Center
Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
9.0 out of 10, Wonderful, (3574)
"The staff and hotel were wonderful. Close to my meeting location and the rooms were exquisite. "
United States
Candy
The price is ₹12,197
₹14,270 total
includes taxes & fees
21 Nov - 22 Nov
Blossom Hotel Houston, Curio Collection by Hilton
Hyatt House Houston Medical Center
3.0 star property
9.2 out of 10, Wonderful, (1136)
"Great stay"
United States
Kurt
The price is ₹11,343
₹13,342 total
includes taxes & fees
21 Nov - 22 Nov
Hyatt House Houston Medical Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.2 out of 10, Very good, (2723)
"We had a wonderful stay"
United States
Laquinza
The price is ₹10,358
₹12,203 total
includes taxes & fees
20 Nov - 21 Nov
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hyatt Regency Houston/Galleria
4.0 star property
9.0 out of 10, Wonderful, (1105)
"Wonderful property!!! Very much enjoyed our stay! "
United States
Matthew
The price is ₹14,157
₹16,666 total
includes taxes & fees
15 Nov - 16 Nov
Hyatt Regency Houston/Galleria
The Lancaster Hotel
4.0 star property
9.8 out of 10, Exceptional, (1000)
"Great place... lots of nice people and nice rooms."
United States
Kenneth
The price is ₹33,979
₹39,756 total
includes taxes & fees
23 Oct - 24 Oct
The Lancaster Hotel
Hyatt Regency Houston West
3.5 star property
8.6 out of 10, Excellent, (1203)
"It’s a beautiful hotel, price is good. "
United States
Yan
The price is ₹10,200
₹11,934 total
includes taxes & fees
14 Nov - 15 Nov
Hyatt Regency Houston West
La Quinta Inn & Suites by Wyndham Houston Southwest
3.0 star property
7.0 out of 10, Good, (1030)
"Great stay. "
United States
Larissa
The price is ₹5,935
₹6,945 total
includes taxes & fees
23 Oct - 24 Oct
La Quinta Inn & Suites by Wyndham Houston Southwest
Holiday Inn Express & Suites Houston – Downtown North by IHG
2.5 star property
9.2 out of 10, Wonderful, (596)
"Great place in a good area near everything. Close to Martin house brewery. "
United States
Carroll
The price is ₹10,728
₹12,551 total
includes taxes & fees
2 Nov - 3 Nov
Holiday Inn Express & Suites Houston – Downtown North by IHG
Omni Houston Hotel
4.0 star property
9.0 out of 10, Wonderful, (1000)
"Really enjoyed my stay. "
United States
kenneth
The price is ₹16,461
₹19,548 total
includes taxes & fees
21 Nov - 22 Nov
Omni Houston Hotel
Haven Inn & Suites Downtown Houston
2.5 star property
9.4 out of 10, Exceptional, (1001)
"Very clean and safe, would stay again"
United States
Krimson
Haven Inn & Suites Downtown Houston
The Royal Sonesta Houston Galleria
4.0 star property
8.4 out of 10, Very good, (1311)
"Great place, staff was nice, "
United States
Jamyal
The price is ₹10,464
₹12,243 total
includes taxes & fees
16 Nov - 17 Nov
The Royal Sonesta Houston Galleria
The Whitehall Houston
4.0 star property
8.6 out of 10, Excellent, (1820)
"Great staff nice rooms"
United States
Matthew
The price is ₹11,167
₹13,066 total
includes taxes & fees
21 Nov - 22 Nov
The Whitehall Houston
Sonesta ES Suites Houston Galleria
3.0 star property
8.2 out of 10, Very good, (1122)
"Nice stay"
United States
Steven
The price is ₹10,389
₹12,155 total
includes taxes & fees
3 Nov - 4 Nov
Sonesta ES Suites Houston Galleria
DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
8.4 out of 10, Very good, (440)
"The hotel is within walking or driving distance which is very convenient for us . Staff was friendly .. "
United States
Michael
The price is ₹12,592
₹14,733 total
includes taxes & fees
17 Nov - 18 Nov
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Quality Inn & Suites NRG Park - Medical Center and Wyndham Houston near NRG Park/Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.