Search Hotels in South Main, Houston
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Our top choices for South Main hotels
Comfort Suites Houston near Medical Center- NRG Stadium
South Main
8.6 out of 10, Excellent, (1000)
"Was a great stay and rigjt next to the stadium all around recomended"
Jason
The price is ₹7,820
₹9,150 total
includes taxes & fees
24 Dec - 25 Dec
Candlewood Suites Houston Medical Center by IHG
South Main
7.4 out of 10, Good, (821)
"Yes the where"
Robert
The price is ₹6,299
₹7,370 total
includes taxes & fees
24 Dec - 25 Dec
Quality Inn & Suites NRG Park - Medical Center
South Main
6.6 out of 10, (1004)
"Clean rooms, quiet property. We will be back again. "
Javier
The price is ₹5,046
₹5,904 total
includes taxes & fees
28 Dec - 29 Dec
Wingate Houston near NRG Park/Medical Center
South Main
6.6 out of 10, (985)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
Roy
The price is ₹6,216
₹7,272 total
includes taxes & fees
10 Dec - 11 Dec
Wyndham Houston near NRG Park/Medical Center
South Main
7.2 out of 10, Good, (1197)
"Love this place. Been staying here for many years. "
Reynaldo
The price is ₹8,009
₹9,371 total
includes taxes & fees
9 Jan - 10 Jan 2026
Blossom Hotel Houston, Curio Collection by Hilton
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3601)
"Everything about our stay was excellent. "
Clarence
The price is ₹11,066
₹12,948 total
includes taxes & fees
16 Dec - 17 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
Northside
While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.
Top South Main Hotel Reviews
Hilton Houston Plaza/Medical Center
10/10 Excellent
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Hotels near popular Houston Attractions
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More accommodation types in South Main
Explore more hotels
- Hilton Americas-Houston
- DoubleTree by Hilton Hotel Houston - Greenway Plaza
- Omni Houston Hotel
- La Quinta Inn & Suites by Wyndham Houston Bush IAH South
- Cambria Hotel Houston Downtown Convention Center
- Crowne Plaza Houston Med Ctr-Galleria Area by IHG
- Heritage Place Houston Brookhollow
- Holiday Inn Houston Intercontinental Airport by IHG
- C. Baldwin, Curio Collection by Hilton
- Hyatt Regency Houston/Galleria
- SpringHill Suites by Marriott Houston Intercontinental Arprt
- Thompson Houston, by Hyatt
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