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Check prices for these dates

Tonight
27 Jan - 28 Jan
Tomorrow
28 Jan - 29 Jan
This weekend
30 Jan - 1 Feb
Next weekend
6 Feb - 8 Feb

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Our top choices for South Main hotels

Premium bedding, pillow-top beds, in-room safe, individually decorated

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,205 reviews)
"Front desk staff was very professional and kind."
United States
MARINA
The price is ₹11,863
₹13,879 total
includes taxes & fees
28 Jan - 29 Jan
Wyndham Houston near NRG Park/Medical Center
Individually decorated, individually furnished, desk, laptop workspace

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,007 reviews)
"Everyone was very nice and courteous, room was excellent and nice welcome package!"
United States
Pamela
The price is ₹8,661
₹10,134 total
includes taxes & fees
3 Feb - 4 Feb
Comfort Suites Houston near Medical Center- NRG Stadium
Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,000 reviews)
"Everything was great"
United States
Efrain
The price is ₹6,290
₹7,359 total
includes taxes & fees
16 Feb - 17 Feb
Quality Inn & Suites NRG Park - Medical Center
Lobby

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,004 reviews)
"Easy access to stadium "
United States
Richard
The price is ₹10,023
₹11,727 total
includes taxes & fees
28 Jan - 29 Jan
Wingate Houston near NRG Park/Medical Center
Exterior

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (830 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is ₹6,805
₹7,962 total
includes taxes & fees
1 Feb - 2 Feb
Candlewood Suites Houston Medical Center by IHG
Terrace/patio

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,653 reviews)
"Great place to stay "
United States
Andrea
The price is ₹8,911
₹10,426 total
includes taxes & fees
20 Feb - 21 Feb
SpringHill Suites by Marriott Houston Intercontinental Arprt
Lobby

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,758 reviews)
"Great place Great staff "
United States
DIANE
The price is ₹7,449
₹8,761 total
includes taxes & fees
8 Feb - 9 Feb
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Exterior

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.9 km from South Main
8.2 out of 10, Very good, (3,318 reviews)
"All amenities and staff was great"
United States
Chiniqua
The price is ₹12,428
₹14,643 total
includes taxes & fees
6 Feb - 7 Feb
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Breakfast, lunch, dinner served; Regional cuisine

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very good, (4,043 reviews)
"Great stay. Clean room and great staff "
United States
Tara Michelle
The price is ₹12,138
₹14,202 total
includes taxes & fees
1 Feb - 2 Feb
Club Quarters Hotel Downtown, Houston
Lobby

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very good, (1,385 reviews)
"Great stay"
Canada
Patricia
The price is ₹6,331
₹7,408 total
includes taxes & fees
4 Feb - 5 Feb
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Exterior

Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport
3.0 star property
31.1 km from South Main
8.4 out of 10, Very good, (1,011 reviews)
"It was a great stay "
United States
Thrideep
The price is ₹7,518
₹8,841 total
includes taxes & fees
21 Feb - 22 Feb
Hilton Garden Inn Houston/Bush Intercontinental Airport
Restaurant

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,005 reviews)
"Was a good hotel "
United States
Kathy
The price is ₹7,088
₹8,293 total
includes taxes & fees
15 Feb - 16 Feb
Tru by Hilton Houston Webster NASA
Terrace/patio

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,136 reviews)
"Clean room, elegant, conveniently priced, close to the airport. "
United States
Corneliu
The price is ₹9,849
₹11,523 total
includes taxes & fees
6 Feb - 7 Feb
Courtyard by Marriott Houston Intercontinental Airport
Rooftop terrace

Le Meridien Houston Downtown

Le Meridien Houston Downtown
4.0 star property
Houston Central Business District, 10.8 km from South Main
8.8 out of 10, Excellent, (1,000 reviews)
"Amazing hotel "
United States
Randy
The price is ₹16,336
₹19,113 total
includes taxes & fees
7 Feb - 8 Feb
Le Meridien Houston Downtown
City view from property

The Whitehall Houston

The Whitehall Houston
4.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1,987 reviews)
"Very friendly staff!"
United States
Jennifer
The price is ₹13,150
₹15,385 total
includes taxes & fees
6 Feb - 7 Feb
The Whitehall Houston
Lobby

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (94 reviews)
"Good hotel for the price "
United States
Miguel
The price is ₹7,863
₹9,200 total
includes taxes & fees
1 Feb - 2 Feb
Best Western Plus Pearland/Houston Medical Center Hotel
Lobby

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,705 reviews)
"Great hospitality and clean, comfy rooms. "
United States
Jamee
The price is ₹14,773
₹17,284 total
includes taxes & fees
5 Feb - 6 Feb
Blossom Hotel Houston, Curio Collection by Hilton
Terrace/patio

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (1,836 reviews)
"Amazing room, great rate! "
United States
Sherri
The price is ₹8,375
₹9,906 total
includes taxes & fees
1 Feb - 2 Feb
Hilton Houston Plaza/Medical Center
2 bars/lounges

Houston Marriott South at Hobby Airport

Houston Marriott South at Hobby Airport
3.5 star property
Southeast Houston, 15.7 km from South Main
8.8 out of 10, Excellent, (1,392 reviews)
"Clean room and the front desk staff was amazing "
United States
Lacey
The price is ₹7,347
₹8,842 total
includes taxes & fees
30 Jan - 31 Jan
Houston Marriott South at Hobby Airport
Lounge

Hyatt Place Houston Downtown

Hyatt Place Houston Downtown
3.0 star property
Houston Central Business District, 11 km from South Main
9.0 out of 10, Wonderful, (1,610 reviews)
"Clean rooms and nice complimentary breakfast. "
United States
Matthew
The price is ₹11,646
₹13,862 total
includes taxes & fees
5 Feb - 6 Feb
Hyatt Place Houston Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green showing city views, modern architecture and a high-rise building

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston which includes a skyscraper and a city

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Menil Collection featuring interior views and art

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Quality Inn & Suites NRG Park - Medical Center and Wingate Houston near NRG Park/Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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