The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West - 2026 Updated Prices

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Teresa

₹33,554 total

includes taxes & fees

30 Nov - 1 Dec

A tropical outdoor area with palm trees, hanging plants, and string lights.

2. Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Maricela

₹18,495 total

includes taxes & fees

3 Nov - 4 Nov

A pool area with lounge chairs and a table, surrounded by palm trees.

3. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

ben

₹33,570 total

includes taxes & fees

3 Nov - 4 Nov

A modern outdoor area with a pool, lounge chairs, and a bar area.

4. H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Kimberly

₹44,759 total

includes taxes & fees

30 Nov - 1 Dec

A gated entrance to Villas Key West with a brick pathway leading to the gate.

5. Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Margaret

₹23,940 total

includes taxes & fees

3 Nov - 4 Nov

A swimming pool with lounge chairs and umbrellas, surrounded by lush greenery and a gazebo.

6. The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Gisele

₹28,722 total

includes taxes & fees

1 Dec - 2 Dec

A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.

7. Alexander's Guesthouse - Adult Exclusive

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Nestor

₹17,024 total

includes taxes & fees

3 Nov - 4 Nov

A porch with a white railing, a bench, and a flag.

8. The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Jennifer

₹35,637 total

includes taxes & fees

24 Nov - 25 Nov

A two-story house with a covered porch, a brick pathway, and a large tree.

9. The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Josh

₹48,835 total

includes taxes & fees

29 Nov - 30 Nov

A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.

10. Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Dennis

₹22,231 total

includes taxes & fees

11 Nov - 12 Nov

A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.

11. Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Elise

₹25,290 total

includes taxes & fees

3 Nov - 4 Nov

A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.

12. The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Justyn

₹19,297 total

includes taxes & fees

3 Nov - 4 Nov

A pool area with lounge chairs and palm trees.

13. Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Anthony

₹46,896 total

includes taxes & fees

1 Dec - 2 Dec

A room with a bed, a ceiling fan, and a window with blinds.

14. The Mermaid & Alligator

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

christine

₹33,082 total

includes taxes & fees

3 Dec - 4 Dec

A large building with a tower, a swimming pool, and lounge chairs.

15. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

Janet

₹32,881 total

includes taxes & fees

8 Nov - 9 Nov

A green house with a white porch, a flag, and a sign advertising a property for sale.

16. L'Habitation Guest House - Adults Only

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Matthew

₹17,692 total

includes taxes & fees

29 Nov - 30 Nov

A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.

17. Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

Shari

₹21,151 total

includes taxes & fees

3 Nov - 4 Nov

A gated entrance with lush green foliage and a white picket fence.

18. Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

August

₹27,299 total

includes taxes & fees

3 Nov - 4 Nov

A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.

19. Alexander Palms Court

Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary

Brenda

₹21,170 total

includes taxes & fees

1 Dec - 2 Dec

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

20. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

Carleen

₹22,658 total

includes taxes & fees

2 Dec - 3 Dec

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,001 reviews	View
Douglas House - Adults Only	3.0 star property	9.8 Exceptional 576 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,000 reviews	View
H2O Suites - Adults Only	3.5 star property	9.8 Exceptional 672 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 279 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

10/10 Excellent

"have stayed here many times. nice location in old Town."

Southernmost Beach Resort and Guesthouses

8/10 Good

"We had a quick stay. Everything was clean and staff was nice. We needed to find a quiet work area for the next day and the evening/night staff was not informed or able to help us out. So instead that guest had to leave early. Other than that all was good. Jenn was very helpful in getting us a golf cart and giving recommendations. Fun activities."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Parking is easy and the staff was helpful and welcoming. We loved the value for the room we got. We booked the owner’s suite and we are excited to come back one day. We enjoyed the happy hour and breakfast. Just a warning the chickens and roosters will wake you up early! But it’s part of the Key West experience!"

Tranquility Guest House

10/10 Excellent

"While check in was a little confusing, everything after that was fantastic. Room was great, spacious, and clean. The location is fabulous. A short walk to the center of Duval st, giving easy access to everything you'd want to do. The staff was super friendly. I needed to let someone know the battery was low on our lock and it was immediately handled, with a very friendly follow up call to make sure everything was all set and if we needed anything. Also nice 2nd floor porch, great for a morning coffee or evening night cap. Would definitely stay at this location again."

Caribbean House

10/10 Excellent

"Check-in was super easy. The location was excellent. I got Lucky and was able to find parking nearby, but having the option to purchase a parking spot is super helpful. The room was small, but I didn’t spend much time there, so it didn’t really matter. The property owners did everything possible to make that small room everything I needed. The shower is very small. I’m short, so it didn’t bother me. But if you are big and tall, I would consider another room or another hotel. Thank you I would definitely book a room here again if I’m ever in Key West."

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1487 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveller data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater and Key West Film Society if you're interested in local theatre.

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Douglas House - Adults Only

3. Orchid Key Inn - Adults Only

4. H2O Suites - Adults Only

5. Key West Villas

6. The Gardens Hotel

7. Alexander's Guesthouse - Adult Exclusive

8. The Conch House Heritage Inn

9. The Marquesa Hotel

10. Duval House

11. Island City House Hotel

12. The Grand Guesthouse

13. Santa Maria Suites

14. The Mermaid & Alligator

15. Southernmost House - Adult Exclusive

16. L'Habitation Guest House - Adults Only

17. Westwinds Inn

18. Coco Plum Inn

19. Alexander Palms Court

20. Silver Palms Inn & Historic Homes

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Frequently asked questions

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