Search Hotels Near Florida Keys National Marine Sanctuary, Key West

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9 Dec - 10 Dec
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10 Dec - 11 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only

3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1003)
"Very nice & peaceful with a wonderful staff. Our second time staying here"
United States
Sandra
The price is ₹22,448
₹25,254 total
includes taxes & fees
16 Dec - 17 Dec
Almond Tree Inn Hotel - Adults Only
Exterior
Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only

3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1001)
"Great location and amazing staff!"
United States
Charles
The price is ₹22,133
₹24,899 total
includes taxes & fees
16 Dec - 17 Dec
Orchid Key Inn - Adults Only
Carriage House | Terrace/patio
The Gardens Hotel

The Gardens Hotel

4.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1001)
"Amazing hotel, the perfect Key West vibe. Clean rooms, delicious breakfast. We will come back again"
United States
Isis
The price is ₹29,287
₹32,948 total
includes taxes & fees
15 Dec - 16 Dec
The Gardens Hotel
King Room D | Balcony
Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages

2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (876)
"The staff was really nice"
United States
doug
The price is ₹20,608
₹23,184 total
includes taxes & fees
21 Dec - 22 Dec
Simonton Court Historic Inn & Cottages
Exterior
Coco Plum Inn

Coco Plum Inn

3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (461)
"Overall great for couple's stay. "
United States
Quazi
The price is ₹14,520
₹16,335 total
includes taxes & fees
15 Dec - 16 Dec
Coco Plum Inn
Outdoor pool, pool loungers
The Conch House Heritage Inn

The Conch House Heritage Inn

3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (144)
"Amazing- I would recommend to anyone going to key west. Cozy, comfy beds, clean, and quiet. 10/10 great experience. "
United States
Savanna
The price is ₹17,300
₹19,462 total
includes taxes & fees
10 Dec - 11 Dec
The Conch House Heritage Inn
Garden
Douglas House

Douglas House

3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (219)
"Very clean room, loved the location!"
United States
Jeffrey Ray
The price is ₹12,335
₹15,264 total
includes taxes & fees
15 Dec - 16 Dec
Douglas House
Exterior
The Marquesa Hotel

The Marquesa Hotel

3.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1001)
"Perfect place to stay. "
United States
Paulette
The price is ₹37,707
₹47,483 total
includes taxes & fees
10 Dec - 11 Dec
The Marquesa Hotel
Deluxe Suite, 1 King Bed, Private Pool | View from room
H2O Suites - Adults Only

H2O Suites - Adults Only

3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (580)
"Great place!!"
United States
Joel
The price is ₹26,934
₹36,381 total
includes taxes & fees
16 Dec - 17 Dec
H2O Suites - Adults Only
Outdoor pool, pool loungers
The Mermaid & Alligator

The Mermaid & Alligator

3.5 star property
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (272)
"Property had several areas to relax."
United States
Mateo
The Mermaid & Alligator
11 Gecko's Garden - Adults Only | Premium bedding, pillow-top beds, individually decorated
Tropical Inn

Tropical Inn

3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (363)
"The place was excellent and the service amazing "
United States
Janae
The price is ₹14,336
₹18,378 total
includes taxes & fees
11 Dec - 12 Dec
Tropical Inn
Premium bedding, iron/ironing board, free WiFi, bed sheets
Weatherstation Inn

Weatherstation Inn

2.5 star property
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (992)
"Wonderful property safe neighborhood convenient to all activities would stay here again."
United States
William
The price is ₹18,742
₹21,084 total
includes taxes & fees
16 Dec - 17 Dec
Weatherstation Inn
Front of property
L'Habitation Guest House

L'Habitation Guest House

2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (920)
"Great place close to all. Manager was very helpful in recommending how to get around the island, what to do and where to eat."
United States
Robert
The price is ₹12,271
₹13,804 total
includes taxes & fees
14 Dec - 15 Dec
L'Habitation Guest House
Fountain
Island City House Hotel

Island City House Hotel

3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1001)
"This is the best place to stay near all the waterfront spots but still in the neighborhoods. Nice pool, ice, washer/dryer, great staff - it is so warm n friendly! Would stay again and again!"
United States
Gregory
The price is ₹15,849
₹17,830 total
includes taxes & fees
15 Dec - 16 Dec
Island City House Hotel
View from property
Duval House

Duval House

3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1002)
"Had a great stay"
United States
Bren Albert
The price is ₹11,524
₹14,899 total
includes taxes & fees
10 Dec - 11 Dec
Duval House
Terrace/patio
Caribbean House

Caribbean House

3.0 star property
Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (282)
"Quaint little place. Well maintained and comfortable. Also located in the Old Town area making walking to virtually everything possible. We really enjoyed our stay here at The Caribbean House. "
United States
Larry
The price is ₹11,828
₹15,559 total
includes taxes & fees
11 Dec - 12 Dec
Caribbean House
Outdoor pool, pool umbrellas, pool loungers
Marrero's Guest Mansion

Marrero's Guest Mansion

3.5 star property
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (335)
"Location very good Staff friendly Pool not well maintained Breakfast and happy hour lacking compared to others"
United States
Scott
The price is ₹29,276
₹32,936 total
includes taxes & fees
4 Jan - 5 Jan 2026
Marrero's Guest Mansion
3 outdoor pools, a heated pool, pool loungers
Ambrosia Key West

Ambrosia Key West

3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1003)
"Great breakfast options, quiet, clean. Walkable where we wanted to go"
United States
Alma D
The price is ₹19,065
₹21,449 total
includes taxes & fees
10 Dec - 11 Dec
Ambrosia Key West
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers
Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns

3.5 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (403)
"Breakfast on the porch every morning was a great start to our days"
United States
Robert
The price is ₹22,894
₹30,316 total
includes taxes & fees
15 Dec - 16 Dec
Ella's Cottages - Key West Historic Inns
Mansion Room #201 - Ocean View with private balcony - Adults Only | Terrace/patio
Southernmost House

Southernmost House

4.0 star property
Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1001)
"Great place with excellent staff. "
United States
Willie
The price is ₹24,241
₹35,631 total
includes taxes & fees
16 Dec - 17 Dec
Southernmost House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

10/10 Excellent
"Beautiful room and amazing reception staff of Annette, Sara, Jody and Richardo. They were very accommodating. "
Daniel 2-night trip
Posted 16 hours ago
Southernmost Beach Resort and Guesthouses

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center which includes interior views

Florida Keys Eco - Discovery Center

4.3/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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Fort Zachary Taylor Park, Key West. State Park in Florida, USA., Shutterstock ID 761867707, Purchase Order: SP-1891 Wave 0, Client/Licensee: Hotels.com

Fort Zachary Taylor Historic State Park

4.4/5 (1,160 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1564 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Southernmost Beach Resort and Guesthouses is one of the top choices for your stay based on our traveller data, and this hotel offers 3 outdoor pools and a full-service spa. It's located just a short 0.7 mi (1.1 km) from Florida Keys National Marine Sanctuary. Other good choices close by include La Concha Key West, Autograph Collection and Winslow's Bungalows - Key West Historic Inns.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1564 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse and Key West Film Society if you're interested in local theatre.

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