East Prairie Travel Guide

Tourist Guide

Bridge over Mississippi River, New Orleans in background
Bridge over Mississippi River, New Orleans in background
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The Mississippi River near Hannibal, Missouri, USA
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is ₹8,181 per night from 25 Jan to 26 Jan
₹8,181
₹9,406 total
25 Jan - 26 Jan
includes taxes & fees
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,005 reviews)
As always it was a perfect visit

Reviewed on 19 Jan 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
The price is ₹9,105 per night from 8 Feb to 9 Feb
₹9,105
₹10,309 total
8 Feb - 9 Feb
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...
8.8/10 Excellent! (463 reviews)
The room was very clean and nicely appointed. The continental breakfast was good with hot food items and hard boiled eggs, oatmeal, fruit, etc. Price was reasonable.

Reviewed on 10 Jan 2026

Hampton Inn Sikeston
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is ₹6,490 per night from 25 Jan to 26 Jan
₹6,490
₹7,397 total
25 Jan - 26 Jan
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...
8.2/10 Very Good! (1,002 reviews)
Clean and well-kept

Reviewed on 19 Jan 2026

Best Western Plus Sikeston
See all 86 properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Prime Fishing & Boating: Tiptonville Home

Prime Fishing & Boating: Tiptonville Home

3 out of 5
Tiptonville TN
Stay at this cottage in Tiptonville. Enjoy free parking and air conditioning. Popular attractions Tiptonville Public Library and Lake County Recreational Park ...
Prime Fishing & Boating: Tiptonville Home
Boat Dock on Reelfoot Lake: Tiptonville Retreat

Boat Dock on Reelfoot Lake: Tiptonville Retreat

3 out of 5
Tiptonville TN
Stay at this cottage in Tiptonville. Enjoy free parking, a marina and balconies. Popular attractions Grassy Island and Horse Island are located nearby.
Boat Dock on Reelfoot Lake: Tiptonville Retreat
Gloria's on Exchange

Gloria's on Exchange

3.5 out of 5
622 Exchange St Union City TN
Stay at this business-friendly holiday home in Union City. Enjoy free Wi-Fi, free parking and a snack bar/deli. Popular attractions Kiwanis Park and Union City ...
Love love love Gloria’s and love Julie and David they are the best hosts.

Reviewed on 3 Jul 2019

Gloria's on Exchange
See all properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Big Oak Tree State Park

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

Big Oak Tree State Park