East Prairie Hotels from ₹5,697

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Check prices for these dates

Tonight
9 Dec - 10 Dec
Tomorrow
10 Dec - 11 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for East Prairie hotels

1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 star property
Sikeston
7.2 out of 10, Good, (1002)
"A great stay in every aspect. "
United States
Gertrude
The price is ₹5,666
₹6,458 total
includes taxes & fees
14 Dec - 15 Dec
Days Inn and Suites by Wyndham Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (440)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is ₹8,567
₹9,700 total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ₹8,369
₹9,476 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express & Suites Sikeston Southwest by IHG
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very good, (1003)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is ₹6,431
₹7,330 total
includes taxes & fees
14 Dec - 15 Dec
Best Western Plus Sikeston
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very good, (716)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is ₹4,999
₹5,697 total
includes taxes & fees
10 Dec - 11 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 star property
Union City
9.2 out of 10, Wonderful, (315)
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is ₹7,267
₹8,629 total
includes taxes & fees
8 Jan - 9 Jan 2026
Sleep Inn at Discovery Park of America
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Everything was clean, staff was friendly "
United States
Matthew
The price is ₹6,755
₹7,766 total
includes taxes & fees
14 Dec - 15 Dec
Pear Tree Inn Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
Sikeston
6.6 out of 10, (561)
"ALL GREAT"
United States
NELSON
The price is ₹5,513
₹6,285 total
includes taxes & fees
20 Dec - 21 Dec
Super 8 by Wyndham Sikeston/Miner Area
Seasonal outdoor pool
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

2.5 star property
Union City
6.8 out of 10, (366)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is ₹4,896
₹5,815 total
includes taxes & fees
8 Jan - 9 Jan 2026
Hospitality House Union City I 69 / US 51
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is ₹8,106
₹9,320 total
includes taxes & fees
13 Dec - 14 Dec
Drury Inn & Suites Sikeston, MO
Lobby
Quality Inn Union City US 51

Quality Inn Union City US 51

2.5 star property
Union City
8.4 out of 10, Very good, (484)
"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is ₹6,043
₹7,176 total
includes taxes & fees
28 Dec - 29 Dec
Quality Inn Union City US 51
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

2.5 star property
Sikeston
8.4 out of 10, Very good, (281)
"Room was clean, breakfast was very good. "
United States
Connie
The price is ₹7,580
₹8,640 total
includes taxes & fees
22 Dec - 23 Dec
Comfort Inn & Suites Sikeston I-55
Bar (on property)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is ₹9,098
₹10,301 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites by Marriott Sikeston
Bar (on property)
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is ₹10,629
₹12,035 total
includes taxes & fees
18 Dec - 19 Dec
TownePlace Suites by Marriott Sikeston
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

2.5 star property
Union City
9.6 out of 10, Exceptional, (164)
"Clean room, nice breakfast"
United States
STUART
The price is ₹8,999
₹10,687 total
includes taxes & fees
22 Dec - 23 Dec
Hampton Inn Union City
Reception
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

2.5 star property
Union City
8.6 out of 10, Excellent, (547)
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is ₹6,479
₹7,693 total
includes taxes & fees
12 Dec - 13 Dec
Country Hearth Inn & Suites Union City
Front of property
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 star property
Portageville
8.0 out of 10, Very good, (725)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Free daily buffet breakfast
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

2.5 star property
Union City
9.4 out of 10, Exceptional, (309)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is ₹9,359
₹11,114 total
includes taxes & fees
9 Jan - 10 Jan 2026
Holiday Inn Express & Suites Union City by IHG
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (273)
"Break fast was excellent "
United States
Uma
The price is ₹6,445
₹7,153 total
includes taxes & fees
27 Dec - 28 Dec
Quality Inn Cairo I-57
Gazebo
Travel Inn

Travel Inn

2.5 star property
Marston
6.0 out of 10, (116)
"Had a great time loved it "
United States
Shyianne
Travel Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and spacious "
Belinda 1-night trip
Posted 2 days ago
Drury Inn & Suites Sikeston, MO

More cheap stays in East Prairie

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
The price is ₹5,666 per night from 14 Dec to 15 Dec
₹5,666
₹6,458 total
14 Dec - 15 Dec
includes taxes & fees
7.2/10 Good! (1,000 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Hampton Inn Sikeston. See all available top hotels, or vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find New Madrid Historical Museum and Columbus-Belmont State Park in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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