A bridge over a muddy river with green trees and hills in the background.

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Mississippi County Accommodation: Most Popular Cities to Stay

A sunset over a calm lake with tall trees reflected in the water.
HotelsHotels

Charleston

Charleston
A tree-lined landscape with a river and fields.
HotelsHotels

East Prairie

East Prairie

Check prices for these dates

This weekend
18 Sept - 20 Sept
Next weekend
25 Sept - 27 Sept

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Our top choices for Mississippi County hotels

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

1. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, 667, (667 reviews)
"Canceled"
United States
Crystal
The price is ₹5,686
₹6,310 total
includes taxes & fees
15 Sept - 16 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.

2. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, 433, (433 reviews)
"Everything was fine for a one night stay."
United States
Jay
The price is ₹6,354
₹7,050 total
includes taxes & fees
16 Sept - 17 Sept
The Riverstone Hotel Charleston-Sikeston
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, 107, (107 reviews)
"Great"
United States
Jackson
The price is ₹7,357
₹8,165 total
includes taxes & fees
15 Sept - 16 Sept
Eagle Inn Charleston
A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, 295, (295 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is ₹6,768
₹7,512 total
includes taxes & fees
2 Oct - 3 Oct
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"The room did not have an extra roll of toilet paper and also the hairdryer did not work. That was the only two things that was not. I was not happy with."
Cabrina 1-night trip
Posted 19 hours ago
Days Inn and Suites by Wyndham Sikeston