Sikeston, Missouri, is a delightful destination that offers a range of attractions for all types of travelers. The downtown area is filled with charming cafes, family-friendly dining options, and unique shopping experiences. The city center is conveniently located close to various hotels, making it an ideal base for exploring Sikeston and its surrounding areas. Visitors can enjoy the friendly atmosphere and warm hospitality of the local people while embarking on exciting excursions to the nearby river, university, and museums. Sikeston truly captures the essence of a quintessential American town with its rich history and vibrant culture.
Photo by Ryan Coleman
Sikeston Hotels from ₹4,536
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Sikeston
Family friendly
Check prices for these dates
Top 10 Sikeston hotels and places to stay

Hampton Inn Sikeston
Hampton Inn Sikeston
8.8 out of 10, Excellent, (361)
The price is ₹10,180
₹11,526 total
includes taxes & fees
1 Aug - 2 Aug

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
9.6 out of 10, Exceptional, (1009)
The price is ₹7,753
₹8,746 total
includes taxes & fees
27 Jul - 28 Jul

Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
9.6 out of 10, Exceptional, (728)
The price is ₹9,447
₹10,658 total
includes taxes & fees
27 Jul - 28 Jul

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
9.4 out of 10, Exceptional, (960)
The price is ₹7,753
₹8,746 total
includes taxes & fees
25 Jul - 26 Jul

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
8.8 out of 10, Excellent, (585)
The price is ₹8,276
₹8,956 total
includes taxes & fees
27 Jul - 28 Jul

The Riverview
The Riverview
9.4 out of 10, Exceptional, (351)
The price is ₹9,073
₹10,235 total
includes taxes & fees
22 Jul - 23 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sikeston and related destinations
Explore Sikeston: its dining, riverfront, museums and more!

Photo by Ryan Coleman
Open Photo by Ryan Coleman
Top Sikeston Hotel Reviews

The Riverview
10/10 Excellent
More cheap stays in Sikeston
More cheap stays in Sikeston

The Riverview
777 Main St, Cape Girardeau, MO
The price is ₹9,073 per night from 22 Jul to 23 Jul
₹9,073
₹10,235 total
22 Jul - 23 Jul
includes taxes & fees
9.2/10 Wonderful! (349 reviews)
Hotels in Sikeston with star rating
Hotels in Sikeston with star rating

3 Star Hotels
15 properties
Accommodation near Sikeston attractions
Accommodation near Sikeston attractions
Find out more about Sikeston
Find out more about Sikeston
Hidden gem of Southern charm in Sikeston, Missouri
Find your hotel in Sikeston
Experience the top activities and must-see sights in Sikeston
How to find great deals and cheap hotels in Sikeston
Discover the flavours of Sikeston
Best time to go to Sikeston
The Sikeston info point: What you need to know
Category | Details |
---|---|
Location | Sikeston, Missouri, United States |
Population | Approximately 16,000 |
Climate | Humid subtropical |
Best time to visit | Spring and fall |
Must-see attractions | Mississippi River, Lambert's Cafe, Sikeston Depot Museum |
Local cuisine | Barbecue, Southern comfort food |
Popular events | Sikeston Jaycee Bootheel Rodeo, Sikeston Cotton Carnival |
Nearby cities | Cape Girardeau, Poplar Bluff, Paducah (Kentucky) |
Explore a world of travel with Expedia
Explore a world of travel with Expedia
More accommodation types in Sikeston
Hotels Near Sikeston, Missouri
- Cape Girardeau Hotels
- Ozarks Hotels
- Southern Illinois Hotels
- Southeastern United States Hotels
- Dexter Hotels
- Charleston Hotels
- Cairo Hotels
- Tiptonville Hotels
- Marston Hotels
- Western Kentucky Hotels
- Portageville Hotels
- Western Tennessee Hotels
- Southeast Missouri Hotels
- Malden Hotels
- New Madrid Hotels
- Miner Hotels
- Benton Hotels
- Wickliffe Hotels
- The South Hotels
- Scott City Hotels
Explore more hotels
- Drury Plaza Hotel Cape Girardeau Conference Center
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Tru By Hilton Cape Girardeau
- Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
- Pear Tree Inn Cape Girardeau West
- Quality Inn
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Courtyard by Marriott Cape Girardeau Downtown
- Drury Inn & Suites Jackson MO
More ways to book
Expedia's Latest Trends
Hotels
Flights
Packages