Compare and book 5 Star hotels in San Sisto, Perugia

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Our top choices for San Sisto 5-star hotels

Sina Brufani

Sina Brufani
5.0 star property
Old Town Perugia
9.2 out of 10, Wonderful, (623)
"Great room"
United States
marilyn
The price is ₹21,632
₹24,325 total
includes taxes & fees
6 Jan - 7 Jan 2026
Sina Brufani

Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World
5.0 star property
Cortona
9.8 out of 10, Exceptional, (228)
"Room was wonderful, bathroom spacious and well appointed. Staff amazing and so friendly "
United States
Melodee
Villa di Piazzano - Small Luxury Hotel of the World

Nun Assisi Relais Spa Museum

Nun Assisi Relais Spa Museum
5.0 star property
Assisi Historic Center
9.8 out of 10, Exceptional, (187)
"It's a beautiful property overall"
United States
paola
Nun Assisi Relais Spa Museum

Hotel Le Tre Vaselle

Hotel Le Tre Vaselle
5.0 star property
Torgiano
8.4 out of 10, Very good, (63)
"Stunning location, beautiful unspoilt village, great for food and wine lovers, super friendly helpful staff"
United Kingdom
simon
Hotel Le Tre Vaselle

Borgo Dei Conti Resort Relais & Chateaux

Borgo Dei Conti Resort Relais & Chateaux
5.0 star property
Perugia
9.2 out of 10, Wonderful, (12)
"The best hotel I've ever stayed. The staff was the absolute best"
United States
Pedro
Borgo Dei Conti Resort Relais & Chateaux

Borgobrufa Spa Resort Adults Only

Borgobrufa Spa Resort Adults Only
5.0 star property
Brufa
9.2 out of 10, Wonderful, (69)
"We really enjoyed our stay at Borgobrufa. The spa was incredible along with the breakfast, dinner and wine. It is a true oasis. "
United States
Andriy
The price is ₹35,542
₹39,096 total
includes taxes & fees
7 Jan - 8 Jan 2026
Borgobrufa Spa Resort Adults Only

Ascesi Resort

Ascesi Resort
5.0 star property
Assisi
10.0 out of 10, Exceptional, (3)
"Beautiful new property, rooms very large (all suites) including sauna inside, wonderful balcony and views. Great breakfast and service. Hotel is being finished so amenities not There yet. "
United States
Enrique
The price is ₹30,889
₹35,247 total
includes taxes & fees
7 Jan - 8 Jan 2026
Ascesi Resort
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Find out more about San Sisto

Stay in Luxury: 5 Star Hotels in San Sisto

There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming leisure time. Treat yourself with a stay in a 5-star hotel during your San Sisto trip. You'll join the multitudes of holidaymakers who have made San Sisto so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in San Sisto and indulge in the finer things in life for a while.

5-Star Hotels in San Sisto

You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs. 

But you aren't going to spend your entire holiday in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in San Sisto are waiting for you to relax after an exciting day.

Make Your Escape

The results are in, and San Sisto 5-star hotels are the place to be when you book your next holiday. If you've been dreaming about a holiday set here, then go ahead and book it. It's time to plan your next great escape -- this is a great time to find 5-star hotel deals in San Sisto! Choose one of our San Sisto 5-star hotels today and soothe yourself in luxe surroundings at your convenience.


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Frequently asked questions

What are the best 5-star hotels in San Sisto?
Get ready for 5-star opulence at Sina Brufani, Hotel Le Tre Vaselle or Borgobrufa Spa Resort Adults Only. These are some of the top-rated escapes in San Sisto based on Expedia guest reviews. Choose your favourite and get a taste of the good life!
How much does it cost to stay in a 5-star hotel in San Sisto?
How much you pay for a 5-star hotel in San Sisto depends on things such as when you want to go and the length of your getaway. A top tip for bagging the best deal? Use our pricing filters to compare the available options for your selected dates.

  • Search for the lowest price per night from ₹8,101

What makes a hotel 5 stars in San Sisto?
From fine dining restaurants and all-day fitness centres to swimming pools and luxury bedding, the 5-star experience in San Sisto is all about luxury and relaxation. But it requires more than just top-notch perks to earn a 5-star rating. Hotels also have to deliver remarkable guest services like in-room beauty treatments, laundry and dry cleaning and concierge services.

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