Photo by Sara Crotts

Plan, book, travel with confidence
Better together
Save up to ₹100,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.4/10 Very good! (2,162 reviews)

"We had a wonderful stay. Everyone we came in contact with during our stay was so kind and caring. It’s so nice, especially when you are going thru a difficult, scary time going thru testing at Mayo Clinic."

Reviewed on 25 Jun 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Stay at this family-friendly motel in Rochester. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

8/10 Very good! (1,003 reviews)

"This is a very reasonable location close enough to everything. It was the quietest location very peaceful. The only downside was the mattress was lumpy. It was a wonderful stay."

Reviewed on 25 Jun 2026

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Northfield. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.2/10 Very good! (663 reviews)

"When you rent a hotel room you expect it to be cleaned daily unless otherwise told. It is utter nonsense to come back to your room and have it not clean and told that's the policy. We pay to have our room cleaned. You can ASK if we don't need it done, but the assumption is to clean. Anyone else tired ..."

Reviewed on 17 Jun 2026

See all 916 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.