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Top Luxury Southeast Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Stay at this business-friendly hotel in Rochester. Enjoy free Wi-Fi, 2 restaurants and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

8.2/10 Very Good! (1,828 reviews)

Room was clean, rooftop, pool, and sauna was a great spot to relax. The convenience of walking around underground in the winter to get to stores and restaurants is genius! Check out at noon too! Only issue was we have a large truck

Reviewed on 11 Dec 2025

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Stay at this family-friendly motel in Rochester. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

7.8/10 Good! (1,005 reviews)

A little out of date and outside lights were all working. But it was just we needed for a stay at Mayo so I was happy with the kitchenette and the lower nightly rate. They also let me cancel a night when we got discharged early

Reviewed on 13 Dec 2025

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN

2 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Northfield. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.2/10 Very Good! (621 reviews)

Staff was courteous.

Reviewed on 6 Dec 2025

See all 936 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.