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Top Luxury Southeastern Indiana Hotels

21c Museum Hotel Louisville

700 W Main Street Louisville KY

9 min walk from KFC Yum Center

Stay at this luxury hotel in Louisville. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the restaurant and the helpful staff ...

9.4/10 Exceptional! (1,000 reviews)

Great staff and a wonderful lobby experience. Room was spacious and clean. Restaurant and bar were both very good.

Reviewed on 19 Mar 2026

The Brown Hotel

335 W Broadway Louisville KY

14 min walk from KFC Yum Center

Stay at this luxury hotel in Louisville. Enjoy free Wi-Fi, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff and the clean ...

9.4/10 Exceptional! (1,182 reviews)

Luxurious historic hotel. Everything is top notch and updated. Even the elevator is incredibly fast. Beautiful rooms.

Reviewed on 25 Mar 2026

Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

3 min walk from KFC Yum Center

Stay at this spa hotel in Louisville. Enjoy free Wi-Fi, an outdoor pool and a full-service spa. Our guests praise the restaurant and the helpful staff in their ...

9/10 Wonderful! (4,091 reviews)

It was fine.

Reviewed on 24 Mar 2026

See all 1,165 properties in Southeastern Indiana

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.