Photo by Southernmost Illinois Tourism Bureau

Plan, book, travel with confidence
Better together
Save up to ₹100,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Southern Illinois Hotels

Super 8 by Wyndham Troy IL/St. Louis Area

910 Edwardsville Rd Troy IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Troy. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in their ...

Rodeway Inn Effingham North

1400 Thelma Keller Ave Effingham IL

4 hours drive from Southern Illinois University

Stay at this motel in Effingham. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their reviews. ...

7.6/10 Good! (1,000 reviews)

"Check-in was an automated video kiosk, where the sound wasn’t very good. The room wasn’t secure as the windows at the Garden level could not lock. the bathroom sink spigot was missing some pieces. In the morning, the smell of Diesel trucks nearby leaked heavily into the room."

Reviewed on 10 Jul 2026

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

100 E Front St Metropolis IL

2 hours drive from Southern Illinois University

Stay at this hotel in Metropolis. Enjoy free parking, 2 restaurants and a casino. Our guests praise the helpful staff and the clean rooms in their reviews. Popular ...

8.4/10 Very good! (1,004 reviews)

"The hotel was very clean, plus the staff was friendly. A drawback was the hot water for the shower was basically tepid at best. The water in the bathroom sink was hot. Overall, it was a pleasant stay."

Reviewed on 4 Aug 2026

See all 1,166 properties in Southern Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.