Our top choices for Southern Illinois hotels

Drury Plaza Hotel Mt. Vernon

Mount Vernon

Judy

₹11,920 total

includes taxes & fees

7 Jun - 8 Jun

Holiday Inn Express & Suites Effingham by IHG

Effingham

Carol

₹14,076 total

includes taxes & fees

21 Jun - 22 Jun

Comfort Suites Mount Vernon

Mount Vernon

Daniel

₹12,102 total

includes taxes & fees

31 May - 1 Jun

Hampton Inn & Suites Effingham

Effingham

Debra

₹16,432 total

includes taxes & fees

31 May - 1 Jun

La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

₹12,236 total

includes taxes & fees

8 Jun - 9 Jun

Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi

Quality Inn Effingham North

Effingham

Jeffery

₹9,870 total

includes taxes & fees

21 Jun - 22 Jun

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Linda

₹10,189 total

includes taxes & fees

31 May - 1 Jun

Desk, laptop workspace, blackout curtains, iron/ironing board

Baymont by Wyndham Effingham

Effingham

Janet

₹8,534 total

includes taxes & fees

5 Jun - 6 Jun

Best Western Plus MidAmerica Hotel

Mascoutah

Kevin

₹12,846 total

includes taxes & fees

7 Jun - 8 Jun

Ramada by Wyndham Vandalia

Vandalia

Tammy

₹9,029 total

includes taxes & fees

31 May - 1 Jun

In-room safe, desk, iron/ironing board, cots/infant beds

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

GREGORY s

₹7,330 total

includes taxes & fees

31 May - 1 Jun

Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Todd

₹12,238 total

includes taxes & fees

7 Jun - 8 Jun

Cobblestone Inn & Suites - Altamont

Altamont

Tonya

₹9,263 total

includes taxes & fees

18 Jun - 19 Jun

Comfort Inn & Suites Marion I-57

Marion

Kelly

₹14,653 total

includes taxes & fees

31 May - 1 Jun

Holiday Inn Effingham by IHG

Effingham

Renee

₹11,197 total

includes taxes & fees

21 Jun - 22 Jun

Best Western Delta Inn

Effingham

Bri

₹12,387 total

includes taxes & fees

8 Jun - 9 Jun

Drury Inn & Suites Marion

Marion

Susan

₹14,166 total

includes taxes & fees

14 Jun - 15 Jun

Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board

Days Inn & Suites by Wyndham Casey

Casey

Tressia

₹7,514 total

includes taxes & fees

27 May - 28 May

SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Jim

₹9,035 total

includes taxes & fees

9 Jun - 10 Jun

Ramada by Wyndham Effingham

Effingham

Breno

₹6,958 total

includes taxes & fees

7 Jun - 8 Jun

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

4.9/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

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Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

6/10 Okay

"old and unkept"

Quality Inn & Suites Metropolis I-24

2/10 Terrible

"But so much wear and tear in our room, it was horrible. Like nothing was getting fixed or replaced. Seemed to be very stuck up or strict with the rules. Only hotel that i've ever been too.Where if you weren't renting a room you wasn't even allowed on the property. So if somebody wanted to come over and hang out for a while, it would have been a big, no."

Comfort Suites Mount Vernon

10/10 Excellent

"I stayed two nights and am particularly grateful for the cleanliness and clean smell. It's just far enough from the freeway that it's pretty quiet. The people upstairs were my "alarm clock" but that happens in most any motel unless you're on the top floor. There was enough parking, though the spaces are narrow - be careful. Air conditioner was efficient - no smell. They provide containers attached to the wall for shampoo, rinse, and lotion so that's easy. I always use the microwave and fridge, which had a good, closed freezer to refreeze my ice. Did not eat the breakfast. The only thing I'd suggest in my room would be to shampoo the carpet near the door area. It well vacuumed, but did need a little deep cleaning in that spot. I always take colored "footies" to walk around in when I stay in motels. When I left, my receipt was already printed so it could be handed to me in a moment."