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Our top choices for Southern Illinois hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Richard

₹11,916 total

includes taxes & fees

1 Nov - 2 Nov

A hotel with a covered entrance, stone pillars, and a modern design.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Doug

₹12,214 total

includes taxes & fees

31 Oct - 1 Nov

A hotel lobby with a reception desk, seating area, and a large screen TV.

3. Comfort Suites Mount Vernon

Mount Vernon

Bruce and Robin

₹12,726 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a beige sectional sofa, a fireplace, and a view of the outside through large glass doors.

4. Hampton Inn & Suites Effingham

Effingham

Scott

₹13,370 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

5. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Susan

₹10,776 total

includes taxes & fees

15 Nov - 16 Nov

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

6. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Steve

₹11,589 total

includes taxes & fees

1 Nov - 2 Nov

An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.

7. Best Western Delta Inn

Effingham

Melissa Rae

₹8,698 total

includes taxes & fees

1 Nov - 2 Nov

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

8. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Kenneth

₹12,718 total

includes taxes & fees

31 Oct - 1 Nov

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

9. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Tad

₹8,550 total

includes taxes & fees

4 Nov - 5 Nov

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

10. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Leslie

₹7,896 total

includes taxes & fees

4 Nov - 5 Nov

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

11. Drury Inn & Suites Marion

Marion

Heather

₹10,620 total

includes taxes & fees

15 Nov - 16 Nov

A Holiday Inn Express hotel with a brick facade, large windows, and a covered entrance.

12. Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Marion

Jennifer

₹12,563 total

includes taxes & fees

8 Nov - 9 Nov

A Comfort Inn & Suites hotel with a covered entrance, multiple floors, and a landscaped front yard.

13. Comfort Inn & Suites Marion I-57

Marion

Suzan

₹11,821 total

includes taxes & fees

8 Nov - 9 Nov

A Country Inn & Suites building with a covered entrance and a sign.

14. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Sonya

₹8,980 total

includes taxes & fees

18 Nov - 19 Nov

A modern indoor pool area with a blue ceiling, large windows, and a pool with a metal ladder.

15. Hampton Inn O'Fallon

O'Fallon

Edmond

₹12,565 total

includes taxes & fees

15 Nov - 16 Nov

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

16. Quality Inn Mount Vernon, IL

Mount Vernon

Ryan

₹7,791 total

includes taxes & fees

8 Nov - 9 Nov

A banquet hall with tables set for a formal event, draped with white fabric and string lights, and a chandelier above.

17. Holiday Inn Effingham by IHG

Effingham

Penny

₹11,299 total

includes taxes & fees

27 Nov - 28 Nov

An outdoor patio with tables and chairs, a brick building, and a parking lot in the background.

18. Fairfield Inn & Suites by Marriott O'Fallon, IL

O'Fallon

Mohamad

₹15,155 total

includes taxes & fees

11 Nov - 12 Nov

A self-service breakfast area with a coffee machine, refrigerated display case, and various food items.

19. Best Western Marion Hotel

Marion

Cornell

₹9,039 total

includes taxes & fees

9 Nov - 10 Nov

A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.

20. Walker's Bluff Casino Resort

Carterville

Ron

₹15,351 total

includes taxes & fees

9 Nov - 10 Nov

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

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A forested valley with autumn foliage, a rocky cliff, and a sunset.

Top Southern Illinois Hotel Reviews

Drury Inn & Suites Marion

10/10 Excellent

"First time staying in a Drury and I'll definitely stay using them more everything was great."

Country Inn & Suites by Radisson, Marion, IL

10/10 Excellent

"This was a wonderful hotel that went the extra mile, with fall decorations in the lobby, fresh cookies at check-in, and every space so clean and fresh smelling. Our room, bed, and shower were great as was the breakfast. I would have loved for the ac/fan to stay on all night, but other than that, it was a great stay."

Quality Inn O'Fallon - St. Louis - Shiloh

8/10 Good

"The staff was awesome! The bathroom however had some stains on the shower curtain. It should have been washed . The bed was so very comfortable! We slept great! Thank you… The staff came right to the room when we couldn’t get the tv remote to work. Asked if we needed anything else.."