Our top choices for Southern Illinois hotels

Drury Plaza Hotel Mt. Vernon

Mount Vernon

Debra

₹12,740 total

includes taxes & fees

26 Apr - 27 Apr

Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

DALTON

₹12,114 total

includes taxes & fees

17 May - 18 May

La Quinta Inn & Suites by Wyndham Effingham

Effingham

William

₹12,033 total

includes taxes & fees

3 May - 4 May

Hampton Inn & Suites Effingham

Effingham

Renita

₹14,612 total

includes taxes & fees

17 May - 18 May

Comfort Suites Mount Vernon

Mount Vernon

Daniel

₹11,979 total

includes taxes & fees

3 May - 4 May

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Linda

₹9,043 total

includes taxes & fees

3 May - 4 May

Best Western Delta Inn

Effingham

James

₹12,033 total

includes taxes & fees

3 May - 4 May

Drury Inn & Suites Marion

Marion

Susan

₹12,213 total

includes taxes & fees

10 May - 11 May

Desk, laptop workspace, blackout curtains, iron/ironing board

Baymont by Wyndham Effingham

Effingham

Teresa

₹8,368 total

includes taxes & fees

3 May - 4 May

Cobblestone Inn & Suites - Altamont

Altamont

Tonya

₹8,866 total

includes taxes & fees

12 May - 13 May

The Principal Hotel

Columbia

David

₹11,565 total

includes taxes & fees

28 Apr - 29 Apr

Holiday Inn Express & Suites Effingham by IHG

Effingham

Monica Orozco and Deborah

₹13,405 total

includes taxes & fees

3 May - 4 May

Ramada by Wyndham Vandalia

Vandalia

Tammy

₹7,160 total

includes taxes & fees

27 Apr - 28 Apr

Holiday Inn Effingham by IHG

Effingham

Renee

₹10,661 total

includes taxes & fees

3 May - 4 May

Best Western Plus MidAmerica Hotel

Mascoutah

Susan

₹12,223 total

includes taxes & fees

17 May - 18 May

Sauna, hot tub, body treatments, hot stone massages

Walker's Bluff Casino Resort

Carterville

Randolph

₹11,827 total

includes taxes & fees

26 Apr - 27 Apr

Comfort Inn & Suites Marion I-57

Marion

Kelly

₹14,289 total

includes taxes & fees

29 Apr - 30 Apr

Fairfield Inn & Suites Marriott Effingham

Effingham

Richard

₹10,042 total

includes taxes & fees

3 May - 4 May

SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Jim

₹8,943 total

includes taxes & fees

12 May - 13 May

Country Inn & Suites by Radisson, Marion, IL

Marion

Gregory

₹11,320 total

includes taxes & fees

3 May - 4 May

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Holiday Rentals in Southern Illinois

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Holiday Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

A summer sunset over Garden of the Gods in Southern Illinois; Shutterstock ID 356954318; Purchase Order: -

Garden of the Gods Recreation Area

4.9/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Superman Statue

4.5/5 (347 reviews)

This 15-foot bronze Superman stands proudly in Metropolis, Illinois, the officially designated "Home of Superman." The adjacent Super Museum houses an extensive collection of rare Man of Steel memorabilia.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

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Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"Great hotel everything was perfect"

Quality Inn O'Fallon IL - St. Louis

10/10 Excellent

"The room was big and clean. The elevator was broken, we had to carry our suitcases up. It was quiet. There were new towels in the bathroom which was great. Bed was comfortable. Breakfast had less variety than expected…. It was close to the gateway arch, felt safe being there."