Our top choices for Southern Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

DAVID

₹12,618 total

includes taxes & fees

28 Jun - 29 Jun

2. Holiday Inn Express & Suites Effingham by IHG

Effingham

Carol

₹13,611 total

includes taxes & fees

21 Jun - 22 Jun

3. Comfort Suites Mount Vernon

Mount Vernon

Todd

₹12,200 total

includes taxes & fees

14 Jun - 15 Jun

4. Hampton Inn & Suites Effingham

Effingham

Debra

₹15,538 total

includes taxes & fees

14 Jun - 15 Jun

5. Drury Inn & Suites Marion

Marion

Brandy

₹13,320 total

includes taxes & fees

4 Jul - 5 Jul

6. Holiday Inn Effingham by IHG

Effingham

Glenn

₹10,825 total

includes taxes & fees

21 Jun - 22 Jun

7. Best Western Plus MidAmerica Hotel

Mascoutah

Scot

₹12,911 total

includes taxes & fees

8 Jul - 9 Jul

8. Cobblestone Inn & Suites - Altamont

Altamont

Dominic

₹9,105 total

includes taxes & fees

10 Jun - 11 Jun

9. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Linda

₹10,149 total

includes taxes & fees

14 Jun - 15 Jun

10. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

₹12,845 total

includes taxes & fees

29 Jun - 30 Jun

Desk, laptop workspace, blackout curtains, iron/ironing board

11. Baymont by Wyndham Effingham

Effingham

Rickey

₹8,577 total

includes taxes & fees

16 Jun - 17 Jun

12. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Holly D

₹13,681 total

includes taxes & fees

28 Jun - 29 Jun

13. Comfort Inn & Suites Marion I-57

Marion

Chase

₹14,182 total

includes taxes & fees

14 Jun - 15 Jun

Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi

14. Quality Inn Effingham North

Effingham

Suzanne

₹9,577 total

includes taxes & fees

21 Jun - 22 Jun

15. Ramada by Wyndham Vandalia

Vandalia

Tammy

₹8,866 total

includes taxes & fees

14 Jun - 15 Jun

In-room safe, desk, iron/ironing board, cots/infant beds

16. Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

Jessie

₹7,621 total

includes taxes & fees

14 Jun - 15 Jun

17. Best Western Plus Parkside Inn & Suites

Olney

James

₹13,453 total

includes taxes & fees

24 Jun - 25 Jun

18. Suite Dreams Hotel

Mattoon

Judd

₹9,164 total

includes taxes & fees

11 Jun - 12 Jun

19. Best Western Delta Inn

Effingham

Bri

₹9,775 total

includes taxes & fees

28 Jun - 29 Jun

20. The Principal Hotel

Columbia

Michelle

₹11,863 total

includes taxes & fees

11 Jun - 12 Jun

View all properties

Holiday Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Holiday Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular Southern Illinois attractions

A summer sunset over Garden of the Gods in Southern Illinois; Shutterstock ID 356954318; Purchase Order: -

Garden of the Gods Recreation Area

4.9/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois