𝗧𝗢𝗣 𝟭𝟬 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southern Illinois (2026)

A forested valley with autumn foliage, a rocky cliff, and a sunset.

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Our top choices for Southern Illinois hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a lamp.

A spacious lobby with a reception desk, seating area, and glass doors leading outside.

An indoor swimming pool with a metal ladder, a warning sign about cold weather, and a view of the outside.

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Kirstyn

₹10,610

₹11,966 total

includes taxes & fees

27 Sept - 28 Sept

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and illuminated pillars.

A hotel reception area with two reception desks, a wall-mounted digital screen, and a security camera.

An indoor swimming pool with clear lane markings, a lifeguard chair, and a window providing natural light.

A modern kitchen with a wooden cabinet, coffee maker, and storage shelves.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

John

₹10,611

₹11,967 total

includes taxes & fees

23 Oct - 24 Oct

A hotel lobby with a reception desk, seating area, and a large screen TV.

A brick building with a patio area featuring wicker furniture and a table.

A Comfort Suites hotel with a spacious parking lot and a modern brick facade.

A hotel room with a marble bathtub, a wooden dining table with chairs, a bed with a headboard, and a nightstand with lamps.

3. Comfort Suites Mount Vernon

Mount Vernon

James

₹11,242

₹12,668 total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

A Fairfield Inn & Suites by Marriott hotel with a parking lot and a clear sky.

A hotel lobby with a reception desk, a red sofa, a potted plant, and a fireplace.

A modern dining area with round tables and chairs, a green booth seating area, and artwork on the walls.

4. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

THERESA

₹10,466

₹11,806 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A parking lot with a Super 8 sign, a white car, and a truck.

A reception area with a counter, a clock, and a chandelier.

A hotel room with a desk, a lamp, a flat-screen TV, a telephone, a microwave, and a trash bin.

5. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Devin

₹6,978

₹7,936 total

includes taxes & fees

24 Sept - 25 Sept

A modern kitchen with wooden cabinets, a refrigerator, a coffee machine, and a microwave. There are red chairs and a table in the dining area.

A hotel with a covered entrance, multiple rooms, and a parking lot.

A laundry area with two washers and dryers, a coin-operated machine, and a sign indicating the coin slot locks out when empty.

A hotel room with two beds, a nightstand, a lamp, and a framed picture on the wall.

6. Quality Inn Mount Vernon, IL

Mount Vernon

Matthew

₹7,227

₹8,212 total

includes taxes & fees

18 Oct - 19 Oct

A small, clean room with a microwave, a vending machine, and a table with chairs.

A reception area with a wooden counter, a tiled floor, and a wall with framed pictures.

A hotel room with two beds, a small kitchenette, and a dining area.

A self-service laundry station with multiple washing machines, a price tag of $1.50, and a sign indicating guest services at the lobby.

7. Rodeway Inn Mount Vernon, IL

Mount Vernon

Emil

₹5,864

₹6,699 total

includes taxes & fees

24 Sept - 25 Sept

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

A spacious lobby with high ceilings, a wooden ceiling, and a large wall with vertical panels. There are seating areas with sofas and chairs, and a staircase on the right.

An outdoor patio area with tables and chairs, large windows, and red umbrellas.

A hotel room with two beds, a desk, a chair, a TV, and a balcony with a view.

8. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Kenneth

₹12,225

₹13,758 total

includes taxes & fees

15 Oct - 16 Oct

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

A modern kitchen with a checkered tile backsplash, wooden flooring, and stainless steel appliances.

A hotel room with two beds, a large window with curtains, a wall-mounted lamp, and a patterned carpet.

A spacious lobby with a large seating area, a reception desk, and a television.

9. Best Western Plus Centralia Hotel & Suites

Centralia

Corey

₹13,288

₹14,879 total

includes taxes & fees

24 Sept - 25 Sept

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

A hotel room with a large bed, a desk with a chair, a flat-screen TV, a bathtub, and framed pictures on the wall.

A modern hotel lobby with a large sun-shaped artwork, multiple seating areas, and a patterned rug.

A modern kitchen area with a counter, various appliances, and food display items.

10. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

₹10,832

₹12,130 total

includes taxes & fees

25 Sept - 26 Sept

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

A hallway with vending machines and a carpeted floor.

A dining area with round tables and chairs, a kitchen with a countertop and appliances, and a hallway leading to another room.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

11. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

MARK

₹7,742

₹8,592 total

includes taxes & fees

4 Oct - 5 Oct

An indoor swimming pool with clear water, marked depth lines, and a lifeguard sign.

A hotel room with two beds, a wooden headboard, a framed picture on the wall, and a red carpet.

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

A hotel reception area with a modern design, including a reception desk, seating area, and a wall-mounted sign for Holiday Inn Express.

12. Holiday Inn Express Metropolis by IHG

Metropolis

Benjamin

₹9,294

₹10,315 total

includes taxes & fees

27 Sept - 28 Sept

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A compact kitchen with a refrigerator, a coffee maker, and a sink.

A modern kitchen with a coffee station, seating area with tables and chairs, and a clock on the wall.

A gym with treadmills, an elliptical, and weight machines.

13. Baymont by Wyndham Effingham

Effingham

Tina

₹7,314

₹8,117 total

includes taxes & fees

1 Oct - 2 Oct

A hotel room with two beds, a desk, a red chair, and a large mirror.

A reception area with a stone wall, a reception desk, and a sign for Days Inn & Suites.

A room with a fireplace, black leather sofas, a coffee table, and a television mounted on the wall.

A gym with exercise equipment including a treadmill, stationary bike, and elliptical machine.

14. Days Inn & Suites by Wyndham Casey

Casey

william

₹6,367

₹7,066 total

includes taxes & fees

27 Sept - 28 Sept

A reception area with a reception desk, a clock, a blue mat, and two potted plants.

A hotel gym with cardio equipment, weight machines, and a mirrored wall.

A hotel room with a sofa, a washing machine, a vending machine, and a staircase.

A hotel room with a bed, bedside tables, a chair, and a window with curtains.

15. Ramada by Wyndham Effingham

Effingham

Kristen

₹6,094

₹6,824 total

includes taxes & fees

28 Sept - 29 Sept

A spacious lobby with a beige sectional sofa, a fireplace, and a view of the outside through large glass doors.

A modern hotel lobby with a long dining table, bar stools, a sofa, and a fireplace.

A treats section with a variety of snacks and beverages, including a refrigerated display and shelves stocked with items like Welch's and Bonde.

A modern living area with a sectional sofa, a fireplace, and a flat-screen TV.

16. Hampton Inn & Suites Effingham

Effingham

Karen

₹12,464

₹13,832 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a desk, a mirror, and a television.

A hotel lobby with a reception desk, a coffee station, and a seating area.

A laundry room with two washing machines, a drying rack, and instructional posters on the wall.

A swimming pool with a clear blue water, surrounded by lounge chairs and a sunbed.

17. Red Roof Inn St Louis - Troy, IL

Troy

crystal

₹6,194

₹6,875 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a bed, a desk, a television, and a bathroom.

A wooden interior with a pool area, a white chair, and a view of the pool through a glass door.

An indoor swimming pool with clear blue water, wooden beams, and brick walls.

A hotel room with a kitchenette, a dining area, a sofa, a bed, and a patterned carpet.

18. Quality Inn Effingham North

Effingham

Sierra

₹7,968

₹8,843 total

includes taxes & fees

4 Oct - 5 Oct

A modern dining area with multiple tables and chairs, a kitchen area with appliances, and a ceiling with recessed lighting and a circular light fixture.

A spacious lobby with a modern design, featuring a large seating area with leather chairs, a kitchen area with a counter and appliances, and a flat-screen TV mounted on the wall.

A hotel room with a large bed, a desk with a chair, a sofa, and a TV.

A modern hotel room with a living area, a kitchenette, and a door leading to another room.

19. Best Western Plus MidAmerica Hotel

Mascoutah

Danny

₹10,472

₹11,936 total

includes taxes & fees

7 Oct - 8 Oct

A self-service breakfast area with a coffee machine, refrigerated display case, and various food items.

A hotel room with a bed, a television, a desk, a coffee machine, and a bathroom visible through an open door.

A spacious lobby with a sofa, chairs, a coffee table, and a dining area with tables and chairs.

A Best Western hotel with a parking lot and a covered entrance.

20. Best Western Marion Hotel

Marion

Cornell

₹8,075

₹9,689 total

includes taxes & fees

27 Sept - 28 Sept

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Holiday Rentals in Southern Illinois

Apartment

A wooden deck with a ramp leading to a covered area, a small window, and a metal chair.

A dining area with a wooden table and chairs, a kitchen with wooden cabinets, and a living area with a sofa and a coffee table.

A modern kitchen with wooden cabinets, a dining table with chairs, and a ceiling fan.

A spacious kitchen with wooden cabinets, a dining table with chairs, and an air conditioning unit.

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

A modern kitchen with dark cabinets, a round dining table, and a tufted bench.

A bedroom with a bed, a chair, a window, and two framed pictures on the wall.

A single-story house with a front porch, a mailbox, and a wreath on the door.

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

Cottage

A living room with a fireplace, leather sofas, and a clock on the wall.

A room with a wooden wall, a window with a view of a deck and outdoor area, and a potted plant with flowers on a table.

A bedroom with a bed, wooden walls, a welcome sign, a television, and a door.

A spacious living room with leather sofas, a dining table, and a ceiling fan.

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

A long, narrow hallway with wooden floors and large windows.

A modern kitchen with a stainless steel refrigerator, oven, and dishwasher. There is a wooden dining table and a brick accent wall.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a tiled floor.

A single-story house with a front porch, a central entrance, and a small staircase leading to the door.

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

A modern kitchen with white cabinetry, a coffee maker, a sink, a dishwasher, and a built-in oven.

A modern kitchen with white cabinets, a wooden dining table, and black chairs.

A two-story house with a well-maintained lawn and patio furniture.

A hallway with a white door, a mirror, a lamp, and a basket on a console table.

Country Home Near EIU & Lake Charleston!

Charleston

"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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O'Fallon Family Sports Park

8.6/10 (137 reviews)

This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.

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Harrah's Metropolis

8.0/10 (310 reviews)

This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards programme to maximise your experience while enjoying Southern classics at the on-site restaurants.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Comfort Inn Edwardsville - St. Louis

8/10 Good

"The room was clean and nice. Air conditioning worked. Breakfast was good. No complaints at all about the room, food or the staff. The elevator did giving off a smoke smell to it but tolerable."

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"The inside and outside pool was very unique. One elevator did not work out for me and my family it took for ever to get to my room. The staff was very friendly and nice. My family and I liked staying at this hotel"

Drury Inn & Suites Marion

10/10 Excellent

"The breakfast was pretty good. The great thing I noticed was the real silverware, not the usual plastic. Kind of a small thing but noticed."

Walker's Bluff Casino Resort

8/10 Good

"Staff was very helpful checking me and my dog in. Was just passing by for the night was a good place to stop and recharge before continuing my journey. Would definitely visit again if life takes me in the area"

Baymont by Wyndham Effingham

8/10 Good

"Good experience"

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

10/10 Excellent

"Very pleased with this stay. The food was good, staff was kind, room was CLEAN and amazing. Will be back!"

Motel 6 Caseyville, IL - Caseyville Il

10/10 Excellent

"Is very good and good staff"

Comfort Suites Fairview Heights - St. Louis

10/10 Excellent

"Enjoyed our stay for the most part. Breakfast wasnt kept up with and stayed empty both days we stayer."

More cheap stays in Southern Illinois

Americas Best Value Inn Collinsville St. Louis

552 Ramada Blvd Collinsville IL

₹5,031

₹5,785 total

11 Oct - 12 Oct

includes taxes & fees

6.4/10 (974 reviews)

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

₹5,119

₹5,886 total

12 Oct - 13 Oct

includes taxes & fees

Country Inn & Suites by Radisson, Effingham, IL

1200 N Raney Effingham IL

₹8,424

₹9,349 total

18 Oct - 19 Oct

includes taxes & fees

Best Western Delta Inn

1509 Hampton Dr Effingham IL

₹8,585

₹9,614 total

4 Oct - 5 Oct

includes taxes & fees

9/10 Wonderful! (1,008 reviews)

Comfort Inn Edwardsville - St. Louis

3080 S State Route 157 Edwardsville IL

₹9,101

₹10,464 total

18 Oct - 19 Oct

includes taxes & fees

8.4/10 Very good! (946 reviews)

Baymont by Wyndham Marion

2608 W Main St Marion IL

₹9,390

₹11,266 total

27 Sept - 28 Sept

includes taxes & fees

8.4/10 Very good! (1,089 reviews)

Hotels in Southern Illinois with star rating

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Motels in Grand Tower

Book Hotels in Southern Illinois on Expedia.com

Southern Illinois Hotels from ₹5,785

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southern Illinois

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southern Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

2. Holiday Inn Express & Suites Mount Vernon by IHG

3. Comfort Suites Mount Vernon

4. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

5. Super 8 by Wyndham Mt. Vernon IL

6. Quality Inn Mount Vernon, IL

7. Rodeway Inn Mount Vernon, IL

8. DoubleTree by Hilton Mt. Vernon

9. Best Western Plus Centralia Hotel & Suites

10. La Quinta Inn & Suites by Wyndham Effingham

11. SureStay Hotel by Best Western Whittington Rend Lake

12. Holiday Inn Express Metropolis by IHG

13. Baymont by Wyndham Effingham

14. Days Inn & Suites by Wyndham Casey

15. Ramada by Wyndham Effingham

16. Hampton Inn & Suites Effingham

17. Red Roof Inn St Louis - Troy, IL

18. Quality Inn Effingham North

19. Best Western Plus MidAmerica Hotel

20. Best Western Marion Hotel

Holiday Rentals in Southern Illinois

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Illinois Vacation Rental Home: Pets Welcome

Cozy Anna Home Near Southern Illinois Attractions!

Country Home Near EIU & Lake Charleston!

Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

World Wide Technology Raceway

O'Fallon Family Sports Park

Harrah's Metropolis

Learn more about Southern Illinois

Top Southern Illinois Hotel Reviews

Comfort Inn Edwardsville - St. Louis

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites Marion

Walker's Bluff Casino Resort

Baymont by Wyndham Effingham

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Motel 6 Caseyville, IL - Caseyville Il

Comfort Suites Fairview Heights - St. Louis

More cheap stays in Southern Illinois

Americas Best Value Inn Collinsville St. Louis

Super 8 by Wyndham O'Fallon

Country Inn & Suites by Radisson, Effingham, IL

Best Western Delta Inn

Comfort Inn Edwardsville - St. Louis

Baymont by Wyndham Marion

Hotels in Southern Illinois with star rating

Explore a world of travel with Expedia

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