Our top choices for Southern Illinois hotels

1. Drury Inn & Suites Marion

Marion

Brandy

₹12,494 total

includes taxes & fees

19 Jul - 20 Jul

2. Suite Dreams Hotel

Mattoon

Judd

₹8,580 total

includes taxes & fees

25 Jun - 26 Jun

3. The Principal Hotel

Columbia

Michelle

₹10,883 total

includes taxes & fees

25 Jun - 26 Jun

4. Hampton Inn & Suites Effingham

Effingham

Andrew

₹13,700 total

includes taxes & fees

19 Jul - 20 Jul

5. Holiday Inn Effingham by IHG

Effingham

Glenn

₹11,132 total

includes taxes & fees

2 Jul - 3 Jul

6. Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

Mark

₹12,399 total

includes taxes & fees

12 Jul - 13 Jul

7. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Jennifer

₹10,040 total

includes taxes & fees

5 Jul - 6 Jul

8. Cobblestone Inn & Suites - Altamont

Altamont

Dominic

₹8,653 total

includes taxes & fees

25 Jun - 26 Jun

9. Charleston House Bed & Breakfast Inn

Charleston

Kristy

₹8,878 total

includes taxes & fees

7 Jul - 8 Jul

10. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

₹11,355 total

includes taxes & fees

5 Jul - 6 Jul

11. Drury Plaza Hotel Mt. Vernon

Mount Vernon

DAVID

₹13,743 total

includes taxes & fees

16 Jul - 17 Jul

12. Fairfield by Marriott Inn & Suites Mattoon

Mattoon

Stephen

₹14,971 total

includes taxes & fees

5 Jul - 6 Jul

Sauna, hot tub, body treatments, hot stone massages

13. Walker's Bluff Casino Resort

Carterville

Monique

₹12,789 total

includes taxes & fees

29 Jun - 30 Jun

14. Ramada by Wyndham Effingham

Effingham

Martin

₹7,119 total

includes taxes & fees

30 Jun - 1 Jul

15. Comfort Suites Effingham Central

Effingham

₹9,913 total

includes taxes & fees

5 Jul - 6 Jul

16. Holiday Inn Express & Suites Effingham by IHG

Effingham

Carol

₹12,935 total

includes taxes & fees

4 Jul - 5 Jul

Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board

17. Days Inn & Suites by Wyndham Casey

Casey

Beth

₹7,093 total

includes taxes & fees

28 Jun - 29 Jun

Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi

18. Quality Inn Effingham North

Effingham

Suzanne

₹9,164 total

includes taxes & fees

5 Jul - 6 Jul

19. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Brandon

₹8,983 total

includes taxes & fees

1 Jul - 2 Jul

20. Best Western Delta Inn

Effingham

Bri

₹11,896 total

includes taxes & fees

9 Jul - 10 Jul

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular Southern Illinois attractions

A summer sunset over Garden of the Gods in Southern Illinois; Shutterstock ID 356954318; Purchase Order: -

Garden of the Gods Recreation Area

9.8/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Holiday Inn Express Metropolis by IHG

10/10 Excellent

"Clean Room"

Drury Inn & Suites St. Louis Fairview Heights

8/10 Good

"Staff takes up the food right at the time they quit serving, even while customers are still eating. Bar staff makes your drink a double instead of letting you get your last two drinks if you get them just before their closing time. Then didn’t think any of that was right."