Our top choices for Southern Illinois hotels

Holiday Inn Express & Suites Effingham by IHG

Effingham

Laura

₹12,591 total

includes taxes & fees

17 May - 18 May

Drury Plaza Hotel Mt. Vernon

Mount Vernon

Lori

₹12,560 total

includes taxes & fees

26 Apr - 27 Apr

La Quinta Inn & Suites by Wyndham Effingham

Effingham

Nancy

₹10,702 total

includes taxes & fees

10 May - 11 May

Hampton Inn & Suites Effingham

Effingham

Corey

₹14,350 total

includes taxes & fees

3 May - 4 May

Comfort Suites Mount Vernon

Mount Vernon

Lisa

₹11,810 total

includes taxes & fees

26 Apr - 27 Apr

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Renee

₹8,915 total

includes taxes & fees

3 May - 4 May

Best Western Plus MidAmerica Hotel

Mascoutah

lisa

₹12,535 total

includes taxes & fees

23 Apr - 24 Apr

Best Western Delta Inn

Effingham

Gayle

₹10,614 total

includes taxes & fees

16 May - 17 May

Holiday Inn Effingham by IHG

Effingham

Susan

₹10,510 total

includes taxes & fees

3 May - 4 May

Cobblestone Inn & Suites - Altamont

Altamont

Kevn

₹8,741 total

includes taxes & fees

21 Apr - 22 Apr

Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Tiffany

₹12,355 total

includes taxes & fees

3 May - 4 May

Drury Inn & Suites St. Louis O'Fallon, IL

O'Fallon

Pamela

₹11,423 total

includes taxes & fees

3 May - 4 May

Drury Inn & Suites Marion

Marion

Eileen

₹12,152 total

includes taxes & fees

10 May - 11 May

Desk, laptop workspace, blackout curtains, iron/ironing board

Baymont by Wyndham Effingham

Effingham

Adrenetta

₹7,626 total

includes taxes & fees

6 May - 7 May

Comfort Inn & Suites Marion I-57

Marion

Dawn

₹14,087 total

includes taxes & fees

29 Apr - 30 Apr

Home2 Suites By Hilton Effingham

Effingham

William

₹14,420 total

includes taxes & fees

26 Apr - 27 Apr

Best Western Plus Centralia Hotel & Suites

Centralia

Sharisa

₹14,984 total

includes taxes & fees

21 Apr - 22 Apr

Sauna, hot tub, body treatments, hot stone massages

Walker's Bluff Casino Resort

Carterville

Paula

₹11,793 total

includes taxes & fees

22 Apr - 23 Apr

Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi

Quality Inn Effingham North

Effingham

Johnny

₹8,766 total

includes taxes & fees

10 May - 11 May

Ramada by Wyndham Vandalia

Vandalia

Mike

₹6,886 total

includes taxes & fees

23 Apr - 24 Apr

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Holiday Rentals in Southern Illinois

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Holiday Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

A summer sunset over Garden of the Gods in Southern Illinois; Shutterstock ID 356954318; Purchase Order: -

Garden of the Gods Recreation Area

4.9/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Superman Statue

4.5/5 (347 reviews)

This 15-foot bronze Superman stands proudly in Metropolis, Illinois, the officially designated "Home of Superman." The adjacent Super Museum houses an extensive collection of rare Man of Steel memorabilia.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

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Top Southern Illinois Hotel Reviews

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"Nice hotel. Staff was great. Breakfast was nice. Coffee was wonderful. Will stay again. "

Holiday Inn Express Metropolis by IHG

8/10 Good

"Staff very friendly. Liked the coffee/tea machine, the tea did not taste like coffee. The breakfast staff was very friendly and kept the area clean. My only dislike was the large cabinet in our room rattled everytime we walked by. Also we were on the second floor, did not like the stomping of the people above us."