Southern Illinois Hotels from โน5,844
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southern Illinois
Pet friendly
Apartยญment
Condo
Family friendly
Waterpark
Cottage
Check prices for these dates
Tonight
25 Aug - 26 AugTomorrow
26 Aug - 27 AugThis weekend
28 Aug - 30 AugNext weekend
4 Sept - 6 SeptOur top choices for Southern Illinois hotels
1. Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
Kirstyn
โน10,627
โน11,985 total
includes taxes & fees
30 Aug - 31 Aug
2. Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
Angela D
โน10,915
โน12,305 total
includes taxes & fees
30 Aug - 31 Aug
3. Comfort Suites Mount Vernon
Comfort Suites Mount VernonMount Vernon
Erica
โน11,370
โน12,810 total
includes taxes & fees
30 Aug - 31 Aug
4. DoubleTree by Hilton Mt. Vernon
DoubleTree by Hilton Mt. VernonMount Vernon
Samuel
โน13,125
โน14,757 total
includes taxes & fees
30 Aug - 31 Aug
5. Super 8 by Wyndham Mt. Vernon IL
Super 8 by Wyndham Mt. Vernon ILMount Vernon
Matthew W,
โน6,721
โน7,651 total
includes taxes & fees
26 Aug - 27 Aug
6. Quality Inn Mount Vernon, IL
Quality Inn Mount Vernon, ILMount Vernon
Kristin
โน7,238
โน8,224 total
includes taxes & fees
6 Sept - 7 Sept
7. SureStay Hotel by Best Western Whittington Rend Lake
SureStay Hotel by Best Western Whittington Rend LakeWhittington
Vinay
โน7,754
โน8,606 total
includes taxes & fees
6 Sept - 7 Sept
8. Days Inn by Wyndham Mount Vernon
Days Inn by Wyndham Mount VernonMount Vernon
Norberto
โน6,917
โน7,869 total
includes taxes & fees
30 Aug - 31 Aug
9. Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica HotelMascoutah
Justin
โน10,067
โน11,475 total
includes taxes & fees
30 Aug - 31 Aug
10. Baymont by Wyndham Marion
Baymont by Wyndham MarionMarion
james
โน7,839
โน9,405 total
includes taxes & fees
30 Aug - 31 Aug
11. Drury Inn & Suites Marion
Drury Inn & Suites MarionMarion
Tara
โน10,148
โน12,175 total
includes taxes & fees
30 Aug - 31 Aug
12. Holiday Inn Express & Suites Effingham by IHG
Holiday Inn Express & Suites Effingham by IHGEffingham
Sheridan
โน10,723
โน12,008 total
includes taxes & fees
30 Aug - 31 Aug
13. Best Western Delta Inn
Best Western Delta InnEffingham
Chris
โน8,464
โน9,478 total
includes taxes & fees
30 Aug - 31 Aug
14. La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham EffinghamEffingham
Alexis
โน9,604
โน10,755 total
includes taxes & fees
30 Aug - 31 Aug
15. Hampton Inn & Suites Effingham
Hampton Inn & Suites EffinghamEffingham
Kate
โน11,698
โน12,982 total
includes taxes & fees
6 Sept - 7 Sept
16. Suite Dreams Hotel
Suite Dreams HotelMattoon
Judd
โน8,277
โน9,269 total
includes taxes & fees
27 Aug - 28 Aug
17. Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, ILEffingham
Jeremiah
โน8,337
โน9,253 total
includes taxes & fees
20 Sept - 21 Sept
18. Ramada by Wyndham Effingham
Ramada by Wyndham EffinghamEffingham
Kristen
โน5,080
โน5,689 total
includes taxes & fees
6 Sept - 7 Sept
19. Best Western Plus Centralia Hotel & Suites
Best Western Plus Centralia Hotel & SuitesCentralia
Corey
โน13,308
โน14,903 total
includes taxes & fees
27 Aug - 28 Aug
20. Super 8 by Wyndham Greenville
Super 8 by Wyndham GreenvilleGreenville
Rebecca
โน6,118
โน6,790 total
includes taxes & fees
30 Aug - 31 Aug
Holiday Rentals in Southern Illinois
Cottage
Harrisburg Home w/ Private Yard + Screened Porch!
Harrisburg Home w/ Private Yard + Screened Porch!Harrisburg
"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."
Apartment
Murphysboro Retreat w/ Deck Near Kinkaid Lake!
Murphysboro Retreat w/ Deck Near Kinkaid Lake!Murphysboro
"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didnโt bring something for it which made me sad. "
Cottage
Peaceful Robinson Home w/ Yard, Near Golf Courses!
Peaceful Robinson Home w/ Yard, Near Golf Courses!Robinson
Cottage
Country Home Near EIU & Lake Charleston!
Country Home Near EIU & Lake Charleston!Charleston
"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...
Cottage
Cozy Anna Home Near Southern Illinois Attractions!
Cozy Anna Home Near Southern Illinois Attractions!Anna
"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southern Illinois attractions
Garden of the Gods Recreation Area
9.8/10 (63 reviews)
See for yourself why Harrisburgโs unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.
O'Fallon Family Sports Park
8.6/10 (137 reviews)
This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.
World Wide Technology Raceway
9.0/10 (2 reviews)
Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Harrah's Metropolis
8.0/10 (310 reviews)
This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards programme to maximise your experience while enjoying Southern classics at the on-site restaurants.
Learn more about Southern Illinois
Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.
See all hotels in Southern Illinois
Photo by Southernmost Illinois Tourism Bureau
Top Southern Illinois Hotel Reviews
Holiday Inn Express & Suites Mount Vernon by IHG
10/10 Excellent
"Weโre discovering a holiday Inn Express and finding them clean, comfortable, and reasonable. Thank you."
Drury Plaza Hotel Mt. Vernon
10/10 Excellent
"It had been a long time since I stayed at a Drury Inn, I was very impressed and was cheaper than Comfort inn and Quality Inn and offered more. Like full breakfast and a Happy hour every evening. They have my choice..Thank you so much."
Comfort Inn Edwardsville - St. Louis
10/10 Excellent
"The staff was amazing!"
Drury Inn & Suites St. Louis O'Fallon, IL
10/10 Excellent
"AMAZING Staff! Very Helpful from check-in to Check-out, but particularly those in the "Extras" area."
Quality Inn & Suites Metropolis I-24
10/10 Excellent
"Tv did not work but everything else was spot on."
Comfort Suites Mount Vernon
10/10 Excellent
"Room was very nice. Breakfast was very good."
Ramada by Wyndham Effingham
10/10 Excellent
"The staff was very friendly and the rooms were clean. If you needed anything they were there to help. Quiet peaceful area too... well maintained. Plenty of parking."
Super 8 by Wyndham O'Fallon
10/10 Excellent
"My stay was good and my room was clean"
DoubleTree by Hilton Mt. Vernon
10/10 Excellent
"What a beautiful place to stay! Our room was spacious and clean. Breakfast was fantastic!"
More cheap stays in Southern Illinois
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
โน5,082
โน5,844 total
26 Aug - 27 Aug
includes taxes & fees
6.6/10 (1,083 reviews)
Baymont by Wyndham Effingham
1811 W Fayette Avenue Effingham IL
โน6,917
โน7,677 total
1 Sept - 2 Sept
includes taxes & fees
Best Western St. Louis Fairview Heights
150 Ludwig Dr Fairview Heights IL
โน7,648
โน8,641 total
2 Sept - 3 Sept
includes taxes & fees
Baymont by Wyndham Marion
2608 W Main St Marion IL
โน7,839
โน9,405 total
30 Aug - 31 Aug
includes taxes & fees
8.4/10 Very good! (1,101 reviews)
Holiday Inn Express Metropolis by IHG
2179 East 5th Street Metropolis IL
โน9,762
โน10,834 total
23 Sept - 24 Sept
includes taxes & fees
8.8/10 Excellent! (1,019 reviews)
Comfort Suites Mount Vernon
404 South 44th Street Mount Vernon IL
โน11,370
โน12,810 total
30 Aug - 31 Aug
includes taxes & fees
9/10 Wonderful! (1,081 reviews)
Hotels in Southern Illinois with star rating
4 Star Hotels
4 properties
3 Star Hotels
81 properties
2 Star Hotels
218 properties
Explore a world of travel with Expedia
- Car hire Alma
- Car hire Alto Pass
- Car hire Chester
- Car hire Colp
- Car hire Cutler
- Car hire Edgewood
- Car hire Energy
- Car hire near Fairfield Country Club
- Car hire Glendale
- Car hire Golden Gate
- Car hire Grand Tower
- Car hire Huey
- Car hire Louisville
- Car hire Macedonia
- Car hire Marion
- Rental cars MidAmerica-St. Louis airport
- Car hire Mount Erie
- Car hire Mount Vernon
- Car hire Nashville
- Car hire New Athens
- Car hire New Memphis
- Car hire Odin
- Car hire Omaha
- Car hire Raleigh
- Car hire Rockwood
- Car hire near Salem Fairgrounds
- Car hire near Salem Township Hospital
- Car hire Salem
- Car hire Scott Air Force Base
- Rental cars Southern Illinois airport
- Car hire Sparta
- Car hire St. Johns
- Car hire Trenton
- Car hire Vandalia
- Car hire Xenia
- Car hire near Washington County
