Our top choices for Southern Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

DAVID

₹13,748 total

includes taxes & fees

16 Jul - 17 Jul

2. Holiday Inn Express & Suites Effingham by IHG

Effingham

Carol

₹12,515 total

includes taxes & fees

5 Jul - 6 Jul

3. Hampton Inn & Suites Effingham

Effingham

Andrew

₹13,814 total

includes taxes & fees

12 Jul - 13 Jul

4. Comfort Suites Mount Vernon

Mount Vernon

Todd

₹12,073 total

includes taxes & fees

21 Jun - 22 Jun

Desk, laptop workspace, blackout curtains, iron/ironing board

5. Baymont by Wyndham Effingham

Effingham

Rickey

₹8,488 total

includes taxes & fees

1 Jul - 2 Jul

6. Best Western Plus MidAmerica Hotel

Mascoutah

Scot

₹12,830 total

includes taxes & fees

21 Jun - 22 Jun

7. Cobblestone Inn & Suites - Altamont

Altamont

Dominic

₹9,010 total

includes taxes & fees

17 Jun - 18 Jun

8. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Jennifer

₹10,003 total

includes taxes & fees

7 Jul - 8 Jul

9. Holiday Inn Effingham by IHG

Effingham

Glenn

₹10,288 total

includes taxes & fees

5 Jul - 6 Jul

In-room safe, desk, iron/ironing board, cots/infant beds

10. Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

Dawn

₹7,747 total

includes taxes & fees

21 Jun - 22 Jun

11. Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

Mark

₹12,404 total

includes taxes & fees

28 Jun - 29 Jun

12. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

₹11,359 total

includes taxes & fees

5 Jul - 6 Jul

Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi

13. Quality Inn Effingham North

Effingham

Suzanne

₹9,417 total

includes taxes & fees

28 Jun - 29 Jun

14. Comfort Inn & Suites Marion I-57

Marion

Chase

₹14,034 total

includes taxes & fees

21 Jun - 22 Jun

15. Drury Inn & Suites Marion

Marion

Brandy

₹13,749 total

includes taxes & fees

28 Jun - 29 Jun

16. Best Western Plus Parkside Inn & Suites

Olney

James

₹13,313 total

includes taxes & fees

7 Jul - 8 Jul

17. Ramada by Wyndham Vandalia

Vandalia

Tammy

₹9,083 total

includes taxes & fees

21 Jun - 22 Jun

18. Super 8 by Wyndham Troy IL/St. Louis Area

Troy

Donta

₹7,148 total

includes taxes & fees

23 Jun - 24 Jun

Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board

19. Days Inn & Suites by Wyndham Casey

Casey

Beth

₹7,474 total

includes taxes & fees

17 Jun - 18 Jun

Iron/ironing board, free WiFi, bed sheets

20. Quality Inn & Suites Metropolis I-24

Metropolis

Howard

₹7,173 total

includes taxes & fees

21 Jun - 22 Jun

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Holiday Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Holiday Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

4.9/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Holiday Inn Express Metropolis by IHG

10/10 Excellent

"Not sure why a previous review mentioned if the property was owned by Indians and a smell. We found the property to be clean and no odor. Room was clean and spacious and the breakfast was great had good variety. Check in/out was a breeze and staff were accommodating."