Our top choices for Southern Illinois hotels

Drury Inn & Suites Marion

Marion

Eileen

₹11,842 total

includes taxes & fees

29 Apr - 30 Apr

Drury Plaza Hotel Mt. Vernon

Mount Vernon

Lori

₹11,760 total

includes taxes & fees

3 May - 4 May

The Principal Hotel

Columbia

bonnie

₹11,518 total

includes taxes & fees

12 May - 13 May

Sauna, hot tub, body treatments, hot stone massages

Walker's Bluff Casino Resort

Carterville

Paula

₹11,793 total

includes taxes & fees

5 May - 6 May

Charleston House Bed & Breakfast Inn

Charleston

peter

₹8,482 total

includes taxes & fees

5 May - 6 May

La Quinta Inn & Suites by Wyndham Effingham

Effingham

Nancy

₹11,888 total

includes taxes & fees

3 May - 4 May

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Renee

₹8,915 total

includes taxes & fees

10 May - 11 May

SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Randall

₹8,816 total

includes taxes & fees

29 Apr - 30 Apr

The Shelby Inn

Shelbyville

Jennifer

₹11,357 total

includes taxes & fees

26 Apr - 27 Apr

Suite, 1 King Bed, Non Smoking (One-Bedroom, Honeymoon) | Jetted bathtub

Seasons Inn & Suites Highland

Highland

Philip

₹8,761 total

includes taxes & fees

23 Apr - 24 Apr

Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Tiffany

₹11,968 total

includes taxes & fees

26 Apr - 27 Apr

Iron/ironing board, free WiFi, bed sheets

Quality Inn & Suites Metropolis I-24

Metropolis

David

₹6,646 total

includes taxes & fees

26 Apr - 27 Apr

Comfort Suites Mount Vernon

Mount Vernon

Lisa

₹11,810 total

includes taxes & fees

26 Apr - 27 Apr

Best Western Delta Inn

Effingham

Gayle

₹10,991 total

includes taxes & fees

7 May - 8 May

Ramada by Wyndham Vandalia

Vandalia

Mike

₹7,074 total

includes taxes & fees

28 Apr - 29 Apr

Desk, laptop workspace, blackout curtains, iron/ironing board

Baymont by Wyndham Effingham

Effingham

Adrenetta

₹7,907 total

includes taxes & fees

16 May - 17 May

Holiday Inn Effingham by IHG

Effingham

Susan

₹10,510 total

includes taxes & fees

10 May - 11 May

Country Inn & Suites by Radisson, Marion, IL

Marion

Mark

₹11,061 total

includes taxes & fees

3 May - 4 May

Fairfield Inn & Suites Marriott Effingham

Effingham

Richard

₹9,900 total

includes taxes & fees

17 May - 18 May

Country Hearth Inn & Suites Edwardsville St. Louis

Edwardsville

Zachary

₹14,851 total

includes taxes & fees

22 Apr - 23 Apr

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Holiday Rentals in Southern Illinois

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Holiday Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

A summer sunset over Garden of the Gods in Southern Illinois; Shutterstock ID 356954318; Purchase Order: -

Garden of the Gods Recreation Area

4.9/5 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Superman Statue

4.5/5 (347 reviews)

This 15-foot bronze Superman stands proudly in Metropolis, Illinois, the officially designated "Home of Superman." The adjacent Super Museum houses an extensive collection of rare Man of Steel memorabilia.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Quality Inn & Suites Metropolis I-24

4/10 Poor

"Room had weird odor, no ice in the ice machine. Not much to choose from for breakfast. Carpet needs to be cleaned. Easy parking was the highlight of the stay. If every place else is full and you just need to get off the road and sleep it might be ok for one night!!"

Holiday Inn Express Metropolis by IHG

8/10 Good

"Staff very friendly. Liked the coffee/tea machine, the tea did not taste like coffee. The breakfast staff was very friendly and kept the area clean. My only dislike was the large cabinet in our room rattled everytime we walked by. Also we were on the second floor, did not like the stomping of the people above us."