Our top choices for Southern Illinois hotels

Drury Inn & Suites Marion

Marion

John

₹8,175 total

includes taxes & fees

1 Feb - 2 Feb

Holiday Inn Express & Suites Effingham by IHG

Effingham

Kristen

₹8,959 total

includes taxes & fees

6 Feb - 7 Feb

Drury Plaza Hotel Mt. Vernon

Mount Vernon

John

₹11,375 total

includes taxes & fees

24 Jan - 25 Jan

Hampton Inn & Suites Effingham

Effingham

Erin

₹10,673 total

includes taxes & fees

1 Feb - 2 Feb

Comfort Suites Mount Vernon

Mount Vernon

Kerry

₹11,764 total

includes taxes & fees

1 Feb - 2 Feb

Iron/ironing board, free WiFi, bed sheets

Quality Inn & Suites Metropolis I-24

Metropolis

Jennifer

₹5,505 total

includes taxes & fees

15 Feb - 16 Feb

La Quinta Inn & Suites by Wyndham Effingham

Effingham

Patricia Mahoney

₹9,518 total

includes taxes & fees

8 Feb - 9 Feb

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Metropolis

Robin

₹12,951 total

includes taxes & fees

21 Jan - 22 Jan

Desk, laptop workspace, blackout curtains, iron/ironing board

Baymont by Wyndham Effingham

Effingham

JoAnn

₹6,861 total

includes taxes & fees

6 Feb - 7 Feb

Country Inn & Suites by Radisson, Effingham, IL

Effingham

Shelley

₹9,005 total

includes taxes & fees

15 Feb - 16 Feb

SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Stephen

₹7,260 total

includes taxes & fees

26 Jan - 27 Jan

Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Marion

Charles

₹9,703 total

includes taxes & fees

1 Feb - 2 Feb

Country Hearth Inn & Suites Edwardsville St. Louis

Edwardsville

Lynn

₹9,507 total

includes taxes & fees

1 Feb - 2 Feb

Best Western Delta Inn

Effingham

C. Mark

₹8,563 total

includes taxes & fees

13 Feb - 14 Feb

Ramada by Wyndham Vandalia

Vandalia

Amanda

₹6,734 total

includes taxes & fees

25 Jan - 26 Jan

In-room safe, desk, iron/ironing board, cots/infant beds

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

Cindy

₹6,274 total

includes taxes & fees

22 Jan - 23 Jan

Home2 Suites By Hilton Effingham

Effingham

Erin

₹11,598 total

includes taxes & fees

26 Jan - 27 Jan

Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi

Quality Inn Effingham North

Effingham

Brenda

₹7,715 total

includes taxes & fees

26 Jan - 27 Jan

Room, 1 Queen Bed, Accessible, Non Smoking | Desk, blackout curtains, iron/ironing board, free cots/infant beds

Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Curt

₹6,535 total

includes taxes & fees

21 Jan - 22 Jan

The Principal Hotel

Columbia

Nancy

₹9,899 total

includes taxes & fees

17 Feb - 18 Feb

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Holiday Rentals in Southern Illinois

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Holiday Home

Villa, 4 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Cottage

Pet-friendly Home w/ Fenced Yard: 'cozy in Casey'

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

Cottage

Illinois Vacation Rental Home: Pets Welcome

Palestine

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

4.8/5 (32 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

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Harrah's Metropolis

4.0/5 (164 reviews)

This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards programme to maximise your experience while enjoying Southern classics at the on-site restaurants.

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Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois