Mesopotamia Luxury Holidays 2026

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Top Luxury Mesopotamia Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free Wi-Fi and a full-service spa. Our guests praise the helpful staff and the property condition ...

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

9.2/10 Wonderful! (677 reviews)

"Beautiful resort, large rooms, great amenities very helpful staff"

Reviewed on 13 Aug 2026

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (1,001 reviews)

"The place is beautiful; breathtaking from the moment you walk in. The staff is so warm, kind, sweet, helpful, for the most part. Very professional too. The food and drinks were delicious. Some very strange thing was the pool experience was uncomfortable. The water was so cold it didn’t match the ..."

Reviewed on 13 Aug 2026

See all 530 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.