Southwest Houston Luxury Holidays 2026

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Top Luxury Southwest Houston Hotels

Hotel Granduca Houston

1080 Uptown Park Blvd Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (1,000 reviews)

"Granduca por siempre el mejor hotel, su personal amable,bonita localización y muy tranquila la zona, ya quiero volver 😍"

Reviewed on 24 Aug 2026

Houston Grand Hotel - River Oaks

1919 Briar Oaks Ln Houston TX

7 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy breakfast (surcharge), 24-hour room service and a 24-hour fitness centre. Popular attractions NRG Stadium and Toyota ...

JW Marriott Houston by the Galleria

5150 Westheimer Rd Houston TX

6 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy 2 restaurants, breakfast (surcharge) and 24-hour room service. Popular attractions NRG Stadium and Westheimer Road ...

See all 1,342 properties in Southwest Houston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.