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Top Luxury Panhandle Plains Hotels

Studio 6 Amarillo, TX – West Medical Center

6801 W Interstate 40 Amarillo TX

4 hours drive from Texas Tech University

Stay at this business-friendly hotel in Amarillo. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the breakfast and the pool in their ...

7.4/10 Good! (1,002 reviews)

Clean spacious rooms, great stay

Reviewed on 11 Dec 2025

Spark by Hilton Amarillo East

2301 East I40 Amarillo TX

4 hours drive from Texas Tech University

Stay at this business-friendly hotel in Amarillo. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

8.8/10 Excellent! (228 reviews)

Clean room nice staff

Reviewed on 15 Dec 2025

Hawthorn Suites by Wyndham Lubbock

4435 Marsha Sharp Fwy Lubbock TX

25 min walk from Texas Tech University

Stay at this business-friendly hotel in Lubbock. Enjoy free Wi-Fi, free parking and a fitness centre. Our guests praise the helpful staff and the clean rooms ...

7.8/10 Good! (1,004 reviews)

Room was clean

Reviewed on 14 Dec 2025

See all 2,163 properties in Panhandle Plains

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.