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Top Luxury Central Missouri Hotels

Ramada by Wyndham Columbia

901 Conley Rd Columbia MO

2 hours drive from Lake of the Ozarks

Stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

2 hours drive from Lake of the Ozarks

Stay at this business-friendly hotel in Columbia. Enjoy free Wi-Fi, 3 restaurants and 3 bars/lounges. Our guests praise the helpful staff and the property condition ...

9/10 Wonderful! (1,000 reviews)

"Classy, old world hotel with a rich history and solid reputation that’s simply losing its luster. Have stayed here a few times in the past and this time was the worst by far!"

Reviewed on 21 Jul 2026

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

20 min drive from Lake of the Ozarks

Stay at this beach resort in Lake Ozark. Enjoy free Wi-Fi, an outdoor pool and a full-service spa. Our guests praise the pool and the helpful staff in their ...

See all 5,257 properties in Central Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.