Southeast Missouri Luxury Holidays

Book a Luxury Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • payments icon
    Better together
    Save up to ₹43,962 when you book a flight and hotel together*
    lob hotels icon
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon
    Rest easy
    Plan, book, and manage your trip all in one place

Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely
Super 8 by Wyndham Pevely
2 out of 5
1711 Highway Z, Pevely, MO
  • 3 hours drive from Mark Twain National Forest
Stay at this business-friendly motel in Pevely. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Pevely Park and Sun Valley Park are located ...
5.6/10 (823 reviews)
Adequate
"Hotel is in rough shape…but if you just need a place to sleep for the night it will fulfill that. Hotel needs a major revamping."

Reviewed on 17 May 2025

Super 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
  • 3 hours drive from Mark Twain National Forest
Stay at this motel in Poplar Bluff. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their ...
7.8/10 Good! (1,002 reviews)
"Friendly staff. Had everything we needed. No microwave. My husband said mattress wasn’t very comfortable but it didn’t bother me that much. No breakfast."

Reviewed on 25 Jun 2025

Motel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 4 hours drive from Mark Twain National Forest
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...
7.2/10 Good! (1,000 reviews)
Keep up the renovations
"This hotel looked like an old apartment building renovation into a hotel with much wrk in progress. Decent stay. Spacious. Very minimal breakfast offerings. The geese outside sure left messes everywhere but the greeting cat was a nice touch"

Reviewed on 28 Jun 2025

Days Inn and Suites by Wyndham Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.