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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Stay at this luxury resort in Cary. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.4/10 Exceptional! (710 reviews)

Awesome hotel

Reviewed on 8 Dec 2025

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Stay at this business-friendly hotel in Chapel Hill. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff ...

9.6/10 Exceptional! (1,002 reviews)

Friendly, helpful staff

Reviewed on 13 Dec 2025

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Stay at this 4-star boutique hotel in Cary. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (716 reviews)

Nice room, friendly staff, festively decorated!

Reviewed on 13 Dec 2025

See all 4,662 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.