Photo by Nikki Benson

Plan, book, travel with confidence
Better together
Save up to ₹43,962 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Stay at this luxury resort in Cary. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.4/10 Exceptional! (728 reviews)

The bed was an absolute dream. The service from every staff member was exceptional. The amenities were fantastic. This hotel is everything you have read and heard about but better.

Reviewed on 23 Jan 2026

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Stay at this business-friendly hotel in Chapel Hill. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff ...

9.4/10 Exceptional! (1,002 reviews)

Awesomr

Reviewed on 13 Jan 2026

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Stay at this 4-star boutique hotel in Cary. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (728 reviews)

Great vibe — elegant and cozy (but not stuffy). The hotel location drew us and did not disappoint. The Downtown Cary Park is easily accessible! Also walked to restaurants a few blocks away.

Reviewed on 8 Jan 2026

See all 4,728 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.