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Top Luxury Eastern Piedmont Hotels

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Stay at this luxury resort in Cary. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff in their reviews. Popular attractions ...

9.6/10 Exceptional! (742 reviews)

Wonderful for a luxury spa getaway

Reviewed on 14 Mar 2026

The Carolina Inn, a Destination by Hyatt Hotel

211 Pittsboro Street Chapel Hill NC

16 min drive from Duke University

Stay at this luxury hotel in Chapel Hill. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff in their ...

9.6/10 Exceptional! (1,000 reviews)

Wonderful place to stay while visiting UNC. The food at the restaurant was delicious. We enjoyed our stay very much.

Reviewed on 14 Mar 2026

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Stay at this boutique hotel in Cary. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.4/10 Exceptional! (737 reviews)

Wonderful place walking distance to everything downtown, only complaint is no parking, you have to find a spot on street or around corner in a parking garage which may not work for everybody, we managed it fine.

Reviewed on 17 Mar 2026

See all 4,822 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.