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Top Luxury Southwest Coast Florida Hotels

Wyvern Hotel, an Ascend Collection Hotel

101 E Retta Esplanade Punta Gorda FL

1 hour drive from Siesta Key Beach

Stay at this luxury hotel in Punta Gorda. Enjoy free Wi-Fi, free parking and 2 restaurants. Our guests praise the helpful staff and the clean rooms in their ...

9/10 Wonderful! (1,008 reviews)

I reserved an accessible room with roll-in shower. The room was spacious enough to use a power wheelchair easily. My problem with the room is that it wasn't on the 1st floor. If there is a fire and evacuation is needed the elevators are not recommended. Handicap accessible rooms should be on ground ...

Reviewed on 6 May 2026

Naples Grande Beach Resort

475 Seagate Drive Naples FL

3 hours drive from Siesta Key Beach

Stay at this luxury resort in Naples. Enjoy 3 outdoor pools, a full-service spa and 4 restaurants. Our guests praise the pool and the helpful staff in their ...

The Ritz-Carlton, Sarasota

1111 Ritz Carlton Dr Sarasota FL

12 min drive from Siesta Key Beach

Stay at this luxury hotel in Sarasota. Enjoy free Wi-Fi, 2 outdoor pools and a full-service spa. Our guests praise the helpful staff in their reviews. Popular ...

9.2/10 Wonderful! (1,002 reviews)

Excellent hotel. We’ll be back

Reviewed on 6 May 2026

See all 46,836 properties in Southwest Coast Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.