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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9.6/10 Exceptional! (1,015 reviews)

Great travel hotel from Texas to Chicago.

Reviewed on 11 May 2026

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...

8.4/10 Very Good! (1,008 reviews)

Room was dirty, there was hair on the wall in the shower, the shower tub was disgusting, the floor was dirty. Breakfast was average nothing great

Reviewed on 11 May 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean ...

9.4/10 Exceptional! (1,010 reviews)

nice and convenient

Reviewed on 11 May 2026

See all 664 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.