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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9.4/10 Exceptional! (1,001 reviews)

Bedding needs to be updated. Pillows smelled and carpet could be cleaned. Bathroom was clean. Staff was friendly and helpful.

Reviewed on 24 Mar 2026

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...

8.4/10 Very Good! (1,000 reviews)

Room was clean, breakfast was good, staff was friendly

Reviewed on 27 Mar 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean ...

9.4/10 Exceptional! (1,000 reviews)

LOVED EVERYTHING ABOUT THIS PLACE

Reviewed on 22 Mar 2026

See all 630 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.