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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9.4/10 Exceptional! (1,003 reviews)

Clean room, friendly staff

Reviewed on 11 Dec 2025

Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...

9.2/10 Wonderful! (1,000 reviews)

This is our go to when we visit relatives

Reviewed on 5 Dec 2025

Best Western Plus Sikeston

120 S Interstate Drive Sikeston MO

4 hours drive from Mark Twain National Forest

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...

8.2/10 Very Good! (1,001 reviews)

Easy parking , quiet and comfortable bed , we’ll stop again on our way back

Reviewed on 7 Dec 2025

See all 620 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.