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Top Kid friendly Southeast Missouri Hotels

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

4 hours drive from Johnson's Shut-ins State Park

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9.6/10 Exceptional! (1,002 reviews)

"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on 15 Jun 2026

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

4 hours drive from Johnson's Shut-ins State Park

Stay at this hotel in Sikeston. Enjoy free breakfast, free parking and a fitness centre. Our guests praise the breakfast and the helpful staff in their reviews. ...

8.4/10 Very good! (1,005 reviews)

"The first room I was assigned had air conditioning that was not blowing cold. The second room had no working air conditioning at all. The third room was fine. The hallway was extremely warm. The woman working the overnight at the desk was extremely apologetic and nice."

Reviewed on 25 Jun 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

4 hours drive from Johnson's Shut-ins State Park

Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean ...

9.4/10 Exceptional! (1,000 reviews)

"I was driving north to WI from South AL for work and needed a somewhat halfway stop, as a solo traveler I recommend this hotel. Easy to get to and felt safe at the hotel and the surrounding areas. I even walked over to Outback Steakhouse for dinner with no issues. Friendly and helpful front desk ..."

Reviewed on 24 Jun 2026

See all 669 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.