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Search Hotels Suites in Southern Illinois

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Check availability on Southern Illinois Hotels Suites

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Southern Illinois Hotels Suites

Property entrance
Hampton Inn & Suites Effingham

Hampton Inn & Suites Effingham

2.5 star property
Effingham
9.6 out of 10, Exceptional, (671)
"Great place. Clean and very comfortable rooms. Great breakfast"
United States
Luis
The price is ₹9,286
₹10,305 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn & Suites Effingham
Free daily buffet breakfast
Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Holiday Inn Express Hotel & Suites Marion Northeast by IHG

2.5 star property
Marion
9.0 out of 10, Wonderful, (924)
"yes the room was great and the staff was great! "
United States
Amador
The price is ₹8,206
₹9,845 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express Hotel & Suites Marion Northeast by IHG
Terrace/patio
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1006)
"Rooms have been painted great breakfast close to interstate and restaurants"
United States
Stephen
The price is ₹9,768
₹11,022 total
includes taxes & fees
12 Dec - 13 Dec
Comfort Suites Mount Vernon
Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3.0 star property
Marion
9.4 out of 10, Exceptional, (1000)
"Great hotel and very clean "
United States
Jose
The price is ₹5,848
₹7,016 total
includes taxes & fees
2 Jan - 3 Jan 2026
Drury Inn & Suites Marion
Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1561)
"Great place to stay. Check in is easy and the hotel people are very nice."
United States
Duane
The price is ₹8,457
₹9,565 total
includes taxes & fees
17 Dec - 18 Dec
Drury Plaza Hotel Mt. Vernon
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

2.5 star property
Whittington
8.8 out of 10, Excellent, (901)
"Great place to stay."
United States
Stephen
The price is ₹6,500
₹7,214 total
includes taxes & fees
31 Dec - 1 Jan 2026
SureStay Hotel by Best Western Whittington Rend Lake
Lobby
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

3.0 star property
Effingham
9.2 out of 10, Wonderful, (1001)
"Clean room, excellent location, pet friendly. Would definitely book again. "
United States
Misty
The price is ₹8,336
₹9,335 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Effingham
Reception
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

2.5 star property
Centralia
9.6 out of 10, Exceptional, (597)
"Very beautiful place to stay "
United States
Valerie
The price is ₹10,878
₹12,181 total
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Plus Centralia Hotel & Suites
Room, 2 Queen Beds, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds
Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 star property
Effingham
8.8 out of 10, Excellent, (1016)
"Clean rooms and kind staff"
United States
Linda
The price is ₹8,413
₹9,337 total
includes taxes & fees
4 Jan - 5 Jan 2026
Country Inn & Suites by Radisson, Effingham, IL
Room, 1 Queen Bed, Accessible, Non Smoking | Desk, blackout curtains, iron/ironing board, free cots/infant beds
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

2.5 star property
Mount Vernon
7.8 out of 10, Good, (1003)
"Clean comfortable room and bed. Great location to many restaurants and shopping. "
United States
Patricia
The price is ₹5,137
₹5,881 total
includes taxes & fees
14 Dec - 15 Dec
Super 8 by Wyndham Mt. Vernon IL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southern Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"Everything was great. Clean rooms, great customer service from the front desk to the kitchen staff. We will stay here again!"
SUE 1-night trip
Posted 5 days ago
Drury Plaza Hotel Mt. Vernon

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Frequently asked questions

How much do hotels with suites in Southern Illinois cost?
You can expect to pay between ₹5,881 and ₹12,181 per night for hotels with suites in Southern Illinois. Whatever your plans or budget, we'll help you find a home away from home with the additional space you need. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best hotels with suites in Southern Illinois?
Southern Illinois offers multiple hotels with suites, with a total average guest review rating of 9.0. Organising a visit to O'Fallon? Look forward to a stay at Drury Inn & Suites St. Louis O'Fallon, IL, a popular 3-star city base with a swimming pool and front desk services. Another sought-after choice with suite rooms is Hampton Inn O'Fallon. It has a 2.5-star rating and conveniences that include an electric car charging station and a swimming pool.
How many hotels with suites are there in Southern Illinois?
Pick from 20 hotels with suites in Southern Illinois. Whether you're coming for work or leisure, Expedia makes it easy to find the perfect digs.
What are the best cheap hotels with suites in Southern Illinois?
It all depends on which part of Southern Illinois you plan to explore. If you're making tracks for O'Fallon, Hampton Inn O'Fallon is a great choice. In addition to suites, this low-priced option includes an electric car charging station and a swimming pool. Thinking about Effingham? Holiday Inn Express And Suites Effingham, an IHG Hotel is an affordable choice with suite rooms in this city. A swimming pool and a garden are among the amenities at this stay. Hotels with suites start at just ₹5,881 per night, which means your getaway doesn't have to hit your wallet hard! Love to see the sights of Southern Illinois without hurting your hip pocket? Add some major free attractions to your travel itinerary, like St. Clair Bowl in O'Fallon. Effingham also has many things to do that don't cost anything, including Mid America Motorworks, My Garage Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels with suites in Southern Illinois?
Yes, so gather the family and plan your Southern Illinois getaway! If O'Fallon is on your agenda, make a booking at Drury Inn & Suites St. Louis O'Fallon, IL. This 3-star option is a popular family-friendly hotel with suites. It also comes with complimentary breakfast and laundry facilities. Another great choice is Drury Inn & Suites St. Louis Fairview Heights. Also in O'Fallon, it holds a 3-star rating and includes complimentary breakfast, a laundry service and suite rooms with the space you require to stretch out. There are plenty of terrific things to do with your little travellers in O'Fallon. The Edge and St. Clair Bowl offer an enjoyable day out.
How can I find cheap hotels with suites in Southern Illinois?
Finding a reasonably priced hotel with suite rooms in Southern Illinois is a breeze with Expedia. Just use our handy filter tool to choose the hotel star rating you prefer, then set your per-night budget. You can also land bigger savings by joining One Key™, our free rewards programme.
Why book your hotel with suites in Southern Illinois with Expedia?
Expedia has unbeatable deals on hotels with suites in Southern Illinois. But our low prices are just the beginning. You'll discover a wide variety of stays to choose from and search filters that make it easy to find your perfect match. So why wait a minute longer? Your Southern Illinois holiday is just clicks away!
What is there to do in Southern Illinois near my hotel with suites?
No matter where you go in Southern Illinois, you'll find loads of fun things to explore here. Planning a few nights in Murphysboro? Lake Murphysboro State Park is a favourite attraction to put on your itinerary.