The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

A spacious lobby with modern seating, large windows, and a city view.

A spacious living room with a fireplace, large windows, and modern furniture.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Randell J

₹11,443

₹12,743 total

includes taxes & fees

1 Nov - 2 Nov

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

A spacious lobby with a central seating area, a staircase, and a fireplace.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Tammie

₹14,458

₹17,319 total

includes taxes & fees

18 Oct - 19 Oct

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A snack and beverage display area with various snacks and drinks.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

3. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Mary

₹10,211

₹11,391 total

includes taxes & fees

1 Nov - 2 Nov

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A modern hotel room with a large bed, a decorative wall, a nightstand, a chair, and a large window with a city view.

4. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Mark

₹17,880

₹19,804 total

includes taxes & fees

18 Oct - 19 Oct

A patio with wicker chairs and a round table with a fire pit.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

A modern hotel room with a dining area, a sofa, a desk, and a chair.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

₹11,660

₹12,982 total

includes taxes & fees

8 Nov - 9 Nov

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern kitchen with a central island, bar stools, pendant lights, and a view through large glass doors.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marnie

₹14,463

₹16,626 total

includes taxes & fees

1 Nov - 2 Nov

A buffet with labeled containers of omelets and other dishes.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

A snack and beverage display with various brands and products.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

Hagel

₹9,230

₹10,316 total

includes taxes & fees

8 Nov - 9 Nov

A modern lobby with a large wooden column, seating areas, and a mural on the wall.

A compact kitchenette with a coffee maker, a small refrigerator, and a cup holder.

A retail space with shelves stocked with various products, a refrigerated display, and a clothing rack.

A balcony with a table and chairs, a television, and a view of a cityscape.

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Samuel

₹11,724

₹13,623 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel room with a large window, a round coffee table, a sofa, a chair, and a small table with a lamp.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

9. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Guy

₹11,228

₹13,935 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk with a computer, a television, and a couch.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A black leather chair, a floor lamp, and a window with a view of parked cars.

A sign for Center Inn with a parking lot and buildings in the background.

10. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

thomas

₹9,062

₹10,131 total

includes taxes & fees

17 Oct - 18 Oct

A multi-level hotel lobby with a central seating area, multiple floors, and a variety of amenities including a bar and dining space.

A multi-level hotel lobby with a central courtyard, featuring a patterned floor, multiple levels of balconies, and a rock formation.

A multi-level hotel lobby with a central atrium, multiple floors, and a variety of seating areas.

A hotel room with a bed, a sofa, a TV, and a desk.

11. Sheraton Sioux Falls Hotel & Convention Center

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Gloria

₹10,019

₹11,181 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

A swimming pool with lounge chairs and umbrellas, a view of the outside, and a sign indicating the hotel name.

12. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

₹8,289

₹9,283 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

A building with a sign that reads "Valley Inn" and another sign indicating a motel.

13. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Robert

₹9,325

₹10,420 total

includes taxes & fees

11 Nov - 12 Nov

An indoor pool area with a slide, seating, and tropical decor.

A lobby with a stone fire feature, seating area, and a reception desk.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

A living room with a fireplace, a television, and a dining area with a table and chairs.

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

₹5,898

₹6,660 total

includes taxes & fees

1 Nov - 2 Nov

15. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Maria

₹4,882

₹5,546 total

includes taxes & fees

18 Oct - 19 Oct

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

A wooden door with a glass panel, leading to a brick-paved entrance.

A dining room with a wooden table, six chairs, and a chandelier.

16. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveller

₹24,184

₹27,476 total

includes taxes & fees

22 Oct - 23 Oct

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

Two vending machines in a hallway with a sign that reads "VENDORS".

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

17. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

₹7,509

₹8,428 total

includes taxes & fees

20 Oct - 21 Oct

A reception area with a counter, a food mart sign, and a security camera.

A hotel room with two beds, a desk, a chair, and a TV.

A Ramada hotel with a covered entrance, parking lot, and handicap-accessible parking spaces.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

18. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Tiffany

₹5,171

₹5,863 total

includes taxes & fees

9 Nov - 10 Nov

A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

An outdoor patio area with tables and chairs, string lights, and a view of the city skyline.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.

19. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 6 km from Sioux Empire Medical Museum

₹9,844

₹10,989 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel lobby with seating areas, a bar, and a kitchen visible in the background.

A hotel exterior with stone facade, outdoor seating area, and a neon sign.

A Hampton Inn & Suites hotel with a well-lit entrance, a covered outdoor area, and a clear night sky.

A snack display area with various chips and snacks, a 'Treats' sign, and a beverage refrigerator.

20. Hampton Inn & Suites Southwest/Sioux Falls

South Sioux Falls, 5.5 km from Sioux Empire Medical Museum

Hettianne

₹10,423

₹11,624 total

includes taxes & fees

15 Nov - 16 Nov

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 367 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,237 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,001 reviews	View
Hotel On Phillips	9.6 Exceptional 1,609 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 678 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

10/10 Excellent

"Beautiful hotel. Great service."

Days Inn by Wyndham Sioux Falls Empire

10/10 Excellent

"Great place for an overnight while passing through. Clean room, comfortable beds, very quiet, and good breakfast. Very good place to stay for the price."

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

8/10 Good

"The stay was great! Although, we did not get the room we booked initially, which was a King Studio Suite. They for some reason changed us to a 2 double beds regular room. We were then told they had no King Studios available. But again, the hotel is great and the staff was great, and we would def stay again. This would be a 5 star review had we gotten the room we actually booked."

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

10/10 Excellent

"Pool"

Holiday Inn Sioux Falls-City Centre by IHG

10/10 Excellent

"Clean rooms and great location"

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Search Hotels Near Sioux Empire Medical Museum, Sioux Falls

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hampton Inn Sioux Falls

4. Hotel On Phillips

5. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

6. Canopy By Hilton Sioux Falls Downtown

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

8. Hilton Garden Inn Sioux Falls Downtown

9. Holiday Inn Sioux Falls-City Centre by IHG

10. The Center Inn

11. Sheraton Sioux Falls Hotel & Convention Center

12. Country Inn & Suites by Radisson, Sioux Falls

13. Valley Inn

14. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

15. Sioux Falls Inn

16. Historic Twin Tudors Inn

17. WoodSpring Suites Sioux Falls

18. Ramada by Wyndham Sioux Falls

19. Comfort Inn & Suites at Sanford Sports Complex

20. Hampton Inn & Suites Southwest/Sioux Falls

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

Days Inn by Wyndham Sioux Falls Empire

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Holiday Inn Sioux Falls-City Centre by IHG

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions