Santa Isabel Hotels from ₹3,206

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
8 Dec - 9 Dec
Tomorrow
9 Dec - 10 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top 10 Santa Isabel hotels and places to stay

Front of property – evening/night
Hotel Araiza Mexicali

Hotel Araiza Mexicali

4.0 star property
Mexicali
8.6 out of 10, Excellent, (1715)
"Great hotel "
United States
Beatriz
The price is ₹7,662
₹8,821 total
includes taxes & fees
29 Dec - 30 Dec
Hotel Araiza Mexicali
Exterior
One Mexicali

One Mexicali

3.0 star property
Mexicali
7.8 out of 10, Good, (1004)
"NICE PLACE"
United States
ROBERTO
The price is ₹6,299
₹7,118 total
includes taxes & fees
4 Jan - 5 Jan 2026
One Mexicali
Daily cooked-to-order breakfast (MXN 290 per person)
Real Inn Mexicali

Real Inn Mexicali

4.0 star property
Civic Center
8.2 out of 10, Very good, (1551)
"It was a good stay. "
United States
Miguel
The price is ₹6,914
₹7,812 total
includes taxes & fees
15 Dec - 16 Dec
Real Inn Mexicali
Outdoor pool
Holiday Inn Express & Suites Mexicali by IHG

Holiday Inn Express & Suites Mexicali by IHG

3.0 star property
Mexicali
9.4 out of 10, Exceptional, (1005)
"Wonderful, excellent stay!"
United States
Martha
The price is ₹6,552
₹7,404 total
includes taxes & fees
9 Jan - 10 Jan 2026
Holiday Inn Express & Suites Mexicali by IHG
Interior entrance
Sleep Inn Mexicali

Sleep Inn Mexicali

3.0 star property
Mexicali
8.2 out of 10, Very good, (1002)
"Friendly staff, clean rooms "
United States
Sara
The price is ₹6,104
₹7,386 total
includes taxes & fees
11 Dec - 12 Dec
Sleep Inn Mexicali
Free daily continental breakfast
City Express Plus by Marriott Mexicali

City Express Plus by Marriott Mexicali

3.5 star property
Mexicali
8.6 out of 10, Excellent, (1003)
"Excellent hotel"
United States
Agustin
The price is ₹6,770
₹7,650 total
includes taxes & fees
28 Dec - 29 Dec
City Express Plus by Marriott Mexicali
Interior
Hotel Siesta Real

Hotel Siesta Real

3.0 star property
Mexicali
8.2 out of 10, Very good, (891)
"Easy check in , close to restaurants and shopping "
United States
Danny
The price is ₹6,500
₹7,380 total
includes taxes & fees
14 Dec - 15 Dec
Hotel Siesta Real
Exterior
Azteca de Oro Mexicali

Azteca de Oro Mexicali

3.0 star property
Mexicali
7.6 out of 10, Good, (441)
"can be noisy at night on the week ends. Convenient good restaurant on site"
United States
gilbert
The price is ₹3,169
₹3,581 total
includes taxes & fees
11 Dec - 12 Dec
Azteca de Oro Mexicali
Front of property
Extended Suites Mexicali Cataviña

Extended Suites Mexicali Cataviña

3.0 star property
Mexicali
8.0 out of 10, Very good, (2190)
"Very nice people clean rooms all new appliances excellent service and great location will recommend to anyone looking for good rest! "
United States
JOSE
Extended Suites Mexicali Cataviña
Free daily continental breakfast
City Express by Marriott Mexicali

City Express by Marriott Mexicali

3.0 star property
Mexicali
8.2 out of 10, Very good, (1007)
"The are is safe and nice restaurants around. "
United States
Judy
The price is ₹6,978
₹7,885 total
includes taxes & fees
24 Dec - 25 Dec
City Express by Marriott Mexicali
Lobby
Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali

2.5 star property
Mexicali
9.6 out of 10, Exceptional, (1009)
"Staff friendly really clean overall Great hotel!!! A plus great location "
United States
Daniel
The price is ₹9,089
₹10,271 total
includes taxes & fees
26 Dec - 27 Dec
Fairfield Inn & Suites by Marriott Mexicali
Exterior
Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

4.0 star property
Mexicali
9.2 out of 10, Wonderful, (1430)
"Great stay! "
United States
Fabiola
The price is ₹8,469
₹9,570 total
includes taxes & fees
28 Dec - 29 Dec
Hotel Lucerna Mexicali
Lobby
City Express Junior by Marriott Mexicali

City Express Junior by Marriott Mexicali

3.0 star property
Mexicali
7.8 out of 10, Good, (1003)
"Excellent location and great price. Will definitely stay here again"
United States
Luis
The price is ₹5,789
₹6,542 total
includes taxes & fees
19 Dec - 20 Dec
City Express Junior by Marriott Mexicali
Daily buffet breakfast for a fee
Fiesta Inn Mexicali

Fiesta Inn Mexicali

3.5 star property
Civic Center
8.2 out of 10, Very good, (1002)
"Great Hotel "
United States
luis
The price is ₹7,143
₹8,071 total
includes taxes & fees
12 Dec - 13 Dec
Fiesta Inn Mexicali
Outdoor pool
Calafia Hotel

Calafia Hotel

3.5 star property
Eguía
8.2 out of 10, Very good, (1007)
"The room was nice and clean. We stayed for a couple of nights and were very happy with our visit."
United States
Lauren
The price is ₹6,357
₹7,255 total
includes taxes & fees
21 Dec - 22 Dec
Calafia Hotel
Property amenity
Courtyard by Marriott Mexicali

Courtyard by Marriott Mexicali

3.0 star property
Mexicali
9.4 out of 10, Exceptional, (812)
"Great location, clean hotel rooms, friendly staff. "
United States
Elizabeth
The price is ₹9,359
₹10,576 total
includes taxes & fees
12 Dec - 13 Dec
Courtyard by Marriott Mexicali
Garden
Hotel Colonial Mexicali

Hotel Colonial Mexicali

3.5 star property
Civic Center
8.0 out of 10, Very good, (1003)
"Great hotel"
United States
Juan
Hotel Colonial Mexicali
Deluxe Suite, Jetted Tub | Laptop workspace, free WiFi, bed sheets
Motel Cies

Motel Cies

3.0 star property
Mexicali
9.0 out of 10, Wonderful, (54)
"Excellent place "
United States
Sandra
The price is ₹4,266
₹5,002 total
includes taxes & fees
16 Dec - 17 Dec
Motel Cies
Exterior
Hotel Hacienda del Indio

Hotel Hacienda del Indio

3.0 star property
Mexicali
7.0 out of 10, Good, (132)
"The room was clean and the parking was safe"
United States
Dulce
The price is ₹2,931
₹3,547 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Hacienda del Indio
Breakfast, lunch, dinner served; Mexican cuisine
Hotel Regis

Hotel Regis

3.0 star property
Mexicali
7.2 out of 10, Good, (115)
"Perfect "
Mexico
LLuviaa
Hotel Regis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Isabel Hotel Reviews

Calafia Hotel

Calafia Hotel

10/10 Excellent
"Todo bien - solo que mi habitacion estaba situada junto a la estacion de Guardias. Toda la noche escuche sus platicas y comentarios, no guardaron silencio"
Manuel 1-night trip
Posted 10 hours ago
Calafia Hotel

More cheap stays in Santa Isabel

Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali

Calzada Manuel Gomez Morin 856 Mexicali BC
The price is ₹9,089 per night from 26 Dec to 27 Dec
₹9,089
₹10,271 total
26 Dec - 27 Dec
includes taxes & fees
9.4/10 Exceptional! (1,009 reviews)

Frequently asked questions

What's the best place for a stay in Santa Isabel?
Hotel Lucerna Mexicali, located 7.5 mi (12.1 km) from the heart of Santa Isabel, is a top choice for your stay, based on our traveller data. Other good choices for your stay in the area are Hotel Araiza Mexicali and Real Inn Mexicali. See all available top hotels, or vacation rentals in Santa Isabel.
If I need to cancel my hotel reservation in Santa Isabel, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Isabel.
What is staying in Santa Isabel like?
Visitors to Santa Isabel will definitely find plenty to explore and enjoy. There are 70 hotels and other accommodation options in the surrounding area. Find out more about Santa Isabel.
What is there to see in Santa Isabel?
Places to visit in the wider area include Mexicali Border Port I, City Forest and Zoo and Plaza Comercial La Cachanilla. You'll also find Eagles Nest Stadium and Imperial Valley Mall in the area. Take a look at what more there is to see and do in Expedia's Santa Isabel guide.
What's the seasonal weather like in Santa Isabel?
The hottest months are usually July and August, with an average temperature of 34°C, while the coldest months are December and January, with an average of 16°C. Average annual precipitation for Santa Isabel is 84 mm.

Explore a world of travel with Expedia