The Best Hotels in San Francisco, Panama City - 2026 Updated Prices

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Property	Property class	Guest rating
Ramada Plaza by Wyndham Panama Punta Pacifica	4.0 star property	9.6 Exceptional 1,346 reviews	View
Courtyard by Marriott Panama Multiplaza Mall	4.0 star property	9.0 Wonderful 1,008 reviews	View
Aloft by Marriott Panama	3.5 star property	8.8 Excellent 1,003 reviews	View
Sheraton Grand Panama	4.0 star property	8.6 Excellent 1,002 reviews	View
San Francisco by Wynwood House	3.0 star property	9.2 Wonderful 63 reviews	View

Where to stay in San Francisco

Find the best San Francisco areas for the activities you enjoy most.

A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

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A harbor with several boats docked in the foreground and a city skyline in the background.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

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A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

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A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

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A coastal cityscape with high-rise buildings, a calm sea, and a rocky shoreline.

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Lotería Station or Santo Tomás Station to explore sights like Via Espana.

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Top San Francisco Hotel Reviews

Hotel Riu Plaza Panama

10/10 Excellent

"I spent my honeymoon and was greeted with champagne and an assorted dish of chocolate-covered strawberries and other goodies. The room was very spacious and clean excellent breakfast and the Resturants were convenient with a wide assortments I will definitely stay here again and recommend the Riu. It"

Ramada Plaza by Wyndham Panama Punta Pacifica

8/10 Good

"I requested late check out when I checked in. We agreed on a set time. I was called twice during the extended time and housekeeping attempted to enter between those calls. Their communication is poor and the staff were hardly apologetic, except for the housekeeper. Evidently a notation for late check out wasn’t made or it wasn’t read by the staff."

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

8/10 Good

"First of all I was a little disappointed that hardly anyone on a property spoke English,😡 I didn't know that before I booked it. The breakfast buffet, was off the hook a lot of choices food was great. The hallway on the way to the elevator from the 4th floor was quite dirty. My room was great everything was good inside there, but their window to look out over the city was very dirty."

Plaza Paitilla Inn Hotel

10/10 Excellent

"Great helpful friendly staff. Big clean room & bathroom. Excellent breakfast buffet! Every morning the staff greeted me with a smile and asked about my stay. They welcomed the small talk and my practice speaking conversational Spanish. Don't miss the opportunity to sit out on the terrace and enjoy the bar area. Loved the city view from the large floor to ceiling windows in my room. Hotel is in a very busy, somewhat noisy area but I loved it. Across the street is Megapolis Outlets (not as many stores as I anticipated), including Hard Rock Cafe and Daiquiri 23 (both serve great food). The only downside was only 3 English speaking TV stations (I didn't inquire if there was an option to change this). My goal during this stay was to experience living like a native and so I did with the TV. Overall this was a very nice hotel on the Cinta Costera with great views of the pacific and city. I would definitely consider staying here again."

Frequently asked questions

What is San Francisco like?

San Francisco is a welcoming neighbourhood that travellers like for its restaurants. Make sure that you visit Multiplaza Pacific Mall and Calle 50 as part of your San Francisco travel plans.

Where is the best hotel for a stay in San Francisco?

Based on our traveller data, Megapolis Hotel Panamá is one of the top choices for your stay in San Francisco. This hotel is steps from Avenida Balboa, and offers a full-service spa and a casino. Other good choices for your stay in the area include Ramada Plaza by Wyndham Panama Punta Pacifica and Decapolis Hotel Panama City.

How many hotels can I expect to find in San Francisco?

If you're searching for places to stay in Panama City, Expedia has something to meet your needs with 320 San Francisco hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in San Francisco, will I receive a refund?

Yes! Most hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to view the best deals in San Francisco.

What is there to do in this Panama City neighbourhood?

While you're in San Francisco, a shopping trip to Multiplaza Pacific Mall, Avenida Balboa or Multicentro Panama might be the perfect way to find that souvenir you've been looking for. Calle 50 and Via Espana are some other stops worth a visit in the neighbourhood. A few places to visit in the area around San Francisco include Bingo 90, Pacific Center and Soho City Center. When you're sightseeing in Panama City, National Shrine of the Heart of Mary and Panama Viejo Museum are also worth a stop.

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Our top choices for San Francisco hotels

1. Ramada Plaza by Wyndham Panama Punta Pacifica

2. Aloft by Marriott Panama

3. Sheraton Grand Panama

4. Courtyard by Marriott Panama Multiplaza Mall

5. Plaza Paitilla Inn Hotel

6. Las Americas Golden Tower Panama

7. Decapolis Hotel Panama City

8. Residence Inn by Marriott Panama City

9. Boutique Apartments Panamá Coco del Mar

10. Megapolis Hotel Panamá

11. San Francisco by Wynwood House

12. JW Marriott Panama

13. Dovle Residences by HMS-Preferred Member

14. Boutique Apartments Atlapa

15. Modern Apartments at the Hub City views

16. Modern Apartments PH Living 73 SF

17. 2BR at First del Sol Modern & Stylish

18. Casa Orquídea

19. Wanders & Yoo

20. Smart Loft-style 1br Apt Near to Shops

Compare popular hotels in San Francisco

Where to stay in San Francisco

Casco Viejo

Bella Vista

El Cangrejo

San Felipe

Calidonia

Top San Francisco Hotel Reviews

Hotel Riu Plaza Panama

Frequently asked questions

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