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Top Trending Hotels Near Santa Ana, Panama City

Luxury Apartment | Balcony
Casco View Apartments

Casco View Apartments

3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (52)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments
Bar (on property)
Hostal La Cigarra

Hostal La Cigarra

2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is ₹2,032
₹2,260 total
includes taxes & fees
7 Jan - 8 Jan 2026
Hostal La Cigarra
Balcony
Hotel República

Hotel República

2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República
Apartment (20) | Iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House

La Manzana by Wynwood House

3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ₹6,884
₹10,048 total
includes taxes & fees
9 Dec - 10 Dec
La Manzana by Wynwood House
Front of property
ART CASCO The Hotel

ART CASCO The Hotel

2.0 star property
Santa Ana
5.8 out of 10, (10)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel
Room, Multiple Bedrooms, Accessible, Smoking | Pool | Outdoor pool
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is ₹13,188
₹14,507 total
includes taxes & fees
8 Dec - 9 Dec
Room-sofa Bed Stay Rooftop Pool & Gym, A
Apartment | Terrace/patio
Casa Quijano 06 By Wynwood House

Casa Quijano 06 By Wynwood House

4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (4)
"Easy to find, seamless check-in "
Canada
Matthew
The price is ₹9,449
₹13,364 total
includes taxes & fees
15 Dec - 16 Dec
Casa Quijano 06 By Wynwood House
Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4627)
"Awesome great place to stay "
United States
Herbert
The price is ₹11,020
₹12,122 total
includes taxes & fees
8 Dec - 9 Dec
Hotel Riu Plaza Panama
3 outdoor pools, pool umbrellas, pool loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5.0 star property
7.5 km from Santa Ana
8.0 out of 10, Very good, (1003)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is ₹15,760
₹17,336 total
includes taxes & fees
17 Dec - 18 Dec
The Westin Playa Bonita Panama
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.4 out of 10, Very good, (1255)
"Excellent hotel very clean and staff very friendly "
United States
ALLENDRA
The price is ₹11,004
₹12,104 total
includes taxes & fees
12 Dec - 13 Dec
Megapolis Hotel Panamá
Outdoor pool, pool umbrellas, pool loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4.0 star property
21.1 km from Santa Ana
8.4 out of 10, Very good, (2300)
"Spacious room, clean, good breakfast "
United States
Juan
The price is ₹9,899
₹10,889 total
includes taxes & fees
23 Dec - 24 Dec
Crowne Plaza Panama Airport by IHG
Living area
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

2.0 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (32)
"Very nice boutique hotel"
United States
Fernando
The price is ₹10,799
₹11,879 total
includes taxes & fees
8 Dec - 9 Dec
ORHO HOTEL BOUTIQUE PANAMA Airport
Outdoor pool, open 7:00 AM to 10:30 PM, free pool cabanas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1858)
"I love the included shuttle and breakfast and how close it is to the airport"
United States
leon
The price is ₹11,254
₹12,379 total
includes taxes & fees
13 Dec - 14 Dec
Riande Aeropuerto Hotel & Casino
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4.0 star property
14.6 km from Santa Ana
8.8 out of 10, Excellent, (1003)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is ₹9,103
₹10,013 total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott Panama Metromall
Meeting facility
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

4.5 star property
Obarrio, 4.1 km from Santa Ana
8.8 out of 10, Excellent, (1000)
"Clean room nice location "
United States
daniel
The price is ₹14,309
₹15,740 total
includes taxes & fees
8 Dec - 9 Dec
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₹20,856
₹22,941 total
includes taxes & fees
12 Dec - 13 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
4 outdoor pools, free pool cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1005)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ₹22,597
₹24,857 total
includes taxes & fees
4 Jan - 5 Jan 2026
JW Marriott Panama
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2134)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
The price is ₹14,229
₹15,652 total
includes taxes & fees
8 Dec - 9 Dec
Plaza Paitilla Inn Hotel
Exterior
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
8.6 out of 10, Excellent, (1433)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is ₹10,059
₹11,065 total
includes taxes & fees
10 Dec - 11 Dec
Decapolis Hotel Panama City
Outdoor pool, pool umbrellas, pool loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1103)
"Property and location was excellent. Staff is very accommodating and helpful. "
Canada
Helen
The price is ₹10,939
₹12,033 total
includes taxes & fees
2 Jan - 3 Jan 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Megapolis Hotel Panamá

Megapolis Hotel Panamá

10/10 Excellent
"Place was great over all "
Sheldon 1-night trip
Posted 1 day ago
Megapolis Hotel Panamá

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Expedia customers rank Hostal La Cigarra the highest for a stay in Santa Ana.
How many hotels can I expect to find in Santa Ana?
Expedia has 112 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.