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Our top choices for Panama City hotels with a spa

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2138)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
The price is ₹9,703
₹10,674 total
includes taxes & fees
2 Jan - 3 Jan 2026
Plaza Paitilla Inn Hotel

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
Tocumen
8.6 out of 10, Excellent, (1848)
"Very nice hotel centered around courtyard and pool. Convenient for airport "
Canada
Miles
The price is ₹11,240
₹12,364 total
includes taxes & fees
13 Dec - 14 Dec
Riande Aeropuerto Hotel & Casino

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very good, (1261)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is ₹10,990
₹12,089 total
includes taxes & fees
19 Dec - 20 Dec
Megapolis Hotel Panamá

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1007)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ₹25,806
₹28,386 total
includes taxes & fees
3 Jan - 4 Jan 2026
JW Marriott Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very good, (1004)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is ₹17,887
₹19,676 total
includes taxes & fees
14 Dec - 15 Dec
The Westin Playa Bonita Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (989)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is ₹12,080
₹13,288 total
includes taxes & fees
9 Jan - 10 Jan 2026
Sheraton Grand Panama

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (554)
"Great hotel and location "
United Kingdom
Russell
The price is ₹33,572
₹36,929 total
includes taxes & fees
15 Dec - 16 Dec
Sofitel Legend Casco Viejo, Panama City

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
"Great place to stay."
United States
Salvador
The price is ₹16,732
₹18,405 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton Panama

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is ₹28,803
₹31,684 total
includes taxes & fees
14 Dec - 15 Dec
Hotel La Compañía Casco Antiguo

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₹20,831
₹22,914 total
includes taxes & fees
12 Dec - 13 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Panama City

Top Panama City attractions for a relaxing vacation

Panama City is a vibrant hub offering a unique blend of urban excitement and lush natural beauty, perfect for travellers seeking spa hotels. Start your journey at the serene Parque Metropolitano, where you can immerse yourself in nature with trails that lead to breathtaking views of the city skyline—ideal for a morning jog or a peaceful stroll before indulging in a spa treatment. Next, explore the historical Casco Viejo, a UNESCO World Heritage site, where cobblestone streets are lined with charming cafés and boutique shops, providing a lovely backdrop for leisurely afternoons. Don’t miss the Biomuseo, an architectural marvel designed by Frank Gehry, showcasing Panama’s rich biodiversity; a visit here can be paired with a rejuvenating spa experience at a nearby hotel. For a taste of local culture, the Mercado de Mariscos offers fresh seafood delicacies—consider a relaxing dinner followed by a detoxifying spa session back at your hotel. Finally, a short trip to the Panama Canal will leave you in awe of this engineering marvel; many hotels in the area offer spa packages that include canal tours, providing the perfect blend of relaxation and adventure. Staying in the upscale Punta Pacifica neighbourhood places you near luxury hotels that feature exceptional spa services, ensuring you feel pampered after a day of exploration.

Find the best hotels & resorts with spas in Panama City

For those seeking rejuvenation and relaxation in Panama City, these hotels offer exceptional spa experiences alongside luxurious amenities to ensure a tranquil stay.

Ramada Plaza By Wyndham Panama Punta Pacífica

  • Why it's great for tailored spa getaway: The Ramada Plaza By Wyndham Panama Punta Pacífica is an excellent destination for spa lovers, a review rating of 9.6 and treatment rooms designed for ultimate relaxation. This hotel combines luxury with comfort, providing an oasis for guests seeking rejuvenation.
  • Other amenities: Guests can enjoy an outdoor pool, complimentary buffet breakfast, and a well-maintained fitness centre available 24 hours. The hotel also offers a terrace for relaxation, concierge services, and premium bedding for a restful night's sleep. Additional features include onsite shopping and free rollaway beds, ensuring a comfortable and convenient stay for all.
  • Neighborhood: San Francisco
  • Nearby attractions: Calle 50 - 0.7 km, Multiplaza Pacific Mall - 0.3 km, ATLAPA Conventions Center - 1 km

Plaza Paitilla Inn Hotel

  • Why it's great for tailored spa getaway: Plaza Paitilla Inn Hotel is a sanctuary for spa lovers, with a wide array of treatments including hot stone massages and reflexology in its onsite spa. With an impressive traveler review rating of 9.4, it ensures an exceptional experience for those looking to unwind and rejuvenate.
  • Other amenities: Alongside its spa offerings, travelers can enjoy an outdoor pool, free buffet breakfast, and secure valet parking. The hotel features a terrace, billiards, and a snack bar for leisurely breaks. With air conditioning and daily housekeeping, every stay is made comfortable and convenient.
  • Neighborhood: Punta Paitilla
  • Nearby attractions: Avenida Balboa - 0.5 km, Cinta Costera - 0.8 km, Multicentro Panama - 1.4 km

Bristol Panama, a Registry Collection Hotel

  • Why it's great for tailored spa getaway: Bristol Panama is a premier destination for spa enthusiasts, featuring a full-service spa that includes steam rooms and an array of specialised treatments. With an excellent traveler review rating of 9.2, it promises a luxurious experience for those seeking relaxation and indulgence.
  • Other amenities: In addition to its spa, travelers can take advantage of the outdoor pool, valet parking, and 24-hour airport shuttle service. The hotel also boasts an onsite art gallery, fitness centre, and terrace, providing a blend of culture and comfort. With designer toiletries and premium bedding, every detail is curated for an upscale experience.
  • Neighborhood: Bella Vista
  • Nearby attractions: Uruguay Street - 0.6 km, Calle 50 - 0.7 km, Avenida Balboa - 0.7 km

Hotel Riu Plaza Panama

  • Why it's great for tailored spa getaway: Why it’s great: The Hotel Riu Plaza Panama is a premier choice for spa enthusiasts, a stellar guest review rating of 9.0. With a luxurious spa featuring various treatment rooms, travelers can indulge in a range of wellness therapies designed to rejuvenate the body and mind, ensuring a restful stay amidst the vibrant city. Guests can also enjoy additional luxurious amenities including an outdoor pool, perfect for relaxing after a spa day.
  • Other amenities:
  • Other amenities: The hotel offers a complimentary buffet breakfast to start your day off right, along with valet parking for convenience. Travelers can take advantage of a well-equipped fitness centre, a poolside bar for refreshments, and onsite shopping options. With features like air conditioning, complimentary toiletries, and a terrace for enjoying the fresh air, every detail caters to a luxurious experience.
  • Neighborhood: Bella Vista
  • Nearby attractions: Uruguay Street - 1.5 km, Calle 50 - 0 km, Via Espana - 1 km

Hotel Riu Plaza Panama

  • Why it's great for tailored spa getaway: The Hotel Riu Plaza Panama stands out as a premier choice for spa enthusiasts, offering a top spa with accessible treatment rooms and a guest review rating of 9.0. Travelers can indulge in a variety of treatments designed to pamper and rejuvenate, making it an ideal retreat after a day exploring the city.
  • Other amenities: Guests can enjoy a range of features including a stunning outdoor pool, complimentary buffet breakfast, and a well-equipped fitness centre. The hotel also offers valet parking, a terrace for relaxation, and an onsite shopping area for added convenience. Additional perks include a private hot tub and a concierge service to assist with local attractions.
  • Neighborhood: Bella Vista
  • Nearby attractions: Uruguay Street - 1.5 km, Calle 50 - 0 km, Via Espana - 1 km

Top Panama City Hotel Reviews

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Frequently asked questions

Looking to holiday at a spa hotel in Panama City?
Forget the stress of everyday life and book yourself a hotel with a spa. Travellers highly recommend Panama City for its array of shops and gourmet restaurants—your day tour starts here. Make sure you enjoy the cafes during your stay. Spa hotels are a great way to take a break from your routine and add a layer of luxury to your holiday.
What is the best spa hotel in Panama City?
Megapolis Hotel Panamá is a top luxury spa hotel featuring 3 bars, a casino, a shopping centre and a rooftop terrace. Enjoy a facial, body scrub or detox wrap at the on-site spa. Other popular spa hotels in Panama City include W Panama and Las Americas Golden Tower Panama.
How many spa hotels are there in Panama City?
Expedia has 24 spa hotels to choose from in Panama City.
What's there to see and do in Panama City?
Enjoy Panama City with a stop at Albrook Shopping Mall, Via Espana and Iglesia del Carmen. If you have a little extra time during your trip, you might want to check out Uruguay Street and Crown Casino.
What is a Panama City spa hotel?
Spa hotels in Panama City have full on-site spas and offer services including facials and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation and relaxation.