Main Street

Liam Maguire's Irish Pub & Restaurant with outdoor seating and flower pots.
A restaurant named Martha's with outdoor seating and potted plants.
A large cruise ship on a calm sea with a person sitting on a bench in the foreground.
A marina with several boats docked, a person rowing a boat, and a house in the background.
A large house by the water with several boats.

Top Hotel Deals

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

4 out of 5
1225 Iyannough Rd Hyannis MA
Margaritaville Resort Cape Cod
Craigville Beach Inn

Craigville Beach Inn

2 out of 5
1338 Craigville Beach Rd Centerville MA
Craigville Beach Inn
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street Hyannis MA
Hyannis Plaza Hotel
The Ocean View

The Ocean View

2.5 out of 5
966 Craigville Beach Road Centerville MA
The Ocean View
Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St Hyannis MA
Hyannis Harbor Hotel
Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection

4 out of 5
135 Route 28 West Yarmouth MA
Uncommoner Hotel by Reverie Boutique Collection
Holiday Inn Express Hyannis Cape Cod by IHG

Holiday Inn Express Hyannis Cape Cod by IHG

2.5 out of 5
1470 Iyannough Road Hyannis MA
Holiday Inn Express Hyannis Cape Cod by IHG
Bayside Resort Hotel

Bayside Resort Hotel

3 out of 5
225 Route 28 West Yarmouth MA
Bayside Resort Hotel
Cape Sands Inn

Cape Sands Inn

2.5 out of 5
149 Main St - RT 28 West Yarmouth MA
Cape Sands Inn
See all 5,944 properties in Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.