Search Hotels in Isle of Palms, Jacksonville

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Our top choices for Isle of Palms hotels

Reception
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (445)
"Great facility to stay."
United States
Gary
The price is ₹13,393
₹15,201 total
includes taxes & fees
20 Dec - 21 Dec
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Lobby lounge
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

Wyndham Garden Jacksonville
3.0 star property
15.5 km from Isle of Palms
7.8 out of 10, Good, (1770)
"Quick check in, clean room, accessible to all the highways ! "
United States
Megan Rose
The price is ₹6,265
₹7,111 total
includes taxes & fees
14 Dec - 15 Dec
Wyndham Garden Jacksonville
View from property
DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront
4.0 star property
22.4 km from Isle of Palms
6.8 out of 10, (1472)
"Loved the hotel "
United States
lucy
The price is ₹9,012
₹10,228 total
includes taxes & fees
16 Dec - 17 Dec
DoubleTree by Hilton Hotel Jacksonville Riverfront
Lobby
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
2.1 km from Isle of Palms
9.4 out of 10, Exceptional, (51)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
The price is ₹10,982
₹12,465 total
includes taxes & fees
20 Dec - 21 Dec
Hilton Jacksonville At Mayo Clinic
Exterior
Holiday Inn Express & Suites Jacksonville Airport by IHG

Holiday Inn Express & Suites Jacksonville Airport by IHG

Holiday Inn Express & Suites Jacksonville Airport by IHG
2.5 star property
31.3 km from Isle of Palms
8.6 out of 10, Excellent, (1010)
"Front desk check in was excellent!"
United States
Janet
The price is ₹8,449
₹9,590 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express & Suites Jacksonville Airport by IHG
Restaurant
Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport
2.5 star property
30.8 km from Isle of Palms
9.0 out of 10, Wonderful, (96)
"Will stay here again "
United States
Jose
The price is ₹6,471
₹7,344 total
includes taxes & fees
14 Dec - 15 Dec
Extended Stay America Premier Suites - Jacksonville - Airport
Standard Double Room, 2 Double Beds, Smoking | Premium bedding, down duvets, in-room safe, blackout curtains
San Marco Inn East

San Marco Inn East

San Marco Inn East
3.0 star property
19.7 km from Isle of Palms
8.4 out of 10, Very good, (1255)
"Nice clean rooms, safe environment and very friendly staff."
United States
Parry J
San Marco Inn East
Daily buffet breakfast (USD 26.95 per person)
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville
4.0 star property
22.3 km from Isle of Palms
9.0 out of 10, Wonderful, (1382)
"Nice stay"
United States
April
The price is ₹12,943
₹14,837 total
includes taxes & fees
19 Dec - 20 Dec
Hyatt Regency Jacksonville
Property amenity
WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk

WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk

WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk
2.0 star property
12.5 km from Isle of Palms
8.8 out of 10, Excellent, (743)
"Staff were great an accommodating. Room was nice and clean. Already booked another stay in January."
United States
Derek
The price is ₹11,384
₹12,921 total
includes taxes & fees
14 Dec - 15 Dec
WaterWalk Extended Stay by Wyndham Jacksonville Deerwood Pk
Lobby
Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport
3.0 star property
31.1 km from Isle of Palms
9.0 out of 10, Wonderful, (2266)
"Room eas clean staff was great"
United States
Joshua
The price is ₹8,710
₹9,886 total
includes taxes & fees
14 Dec - 15 Dec
Hyatt Place Jacksonville Airport
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.6 km from Isle of Palms
9.0 out of 10, Wonderful, (3432)
"Excellent location & property "
United States
Doris
The price is ₹12,862
₹14,599 total
includes taxes & fees
21 Dec - 22 Dec
Margaritaville Jacksonville Beach
Property amenity
Days Inn by Wyndham Orange Park/Jacksonville

Days Inn by Wyndham Orange Park/Jacksonville

Days Inn by Wyndham Orange Park/Jacksonville
2.0 star property
27.8 km from Isle of Palms
7.6 out of 10, Good, (1001)
"Friendly and courteous staff, clean room, very good dining options around."
United States
Ben Jasad
The price is ₹5,960
₹6,705 total
includes taxes & fees
9 Jan - 10 Jan 2026
Days Inn by Wyndham Orange Park/Jacksonville
Lobby
Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk
3.5 star property
22 km from Isle of Palms
8.2 out of 10, Very good, (1608)
"We liked our stay"
United States
Lorie
The price is ₹8,818
₹10,008 total
includes taxes & fees
1 Jan - 2 Jan 2026
Southbank Hotel by Marriott Jacksonville Riverwalk
Exterior
WoodSpring Suites Jacksonville - South

WoodSpring Suites Jacksonville - South

WoodSpring Suites Jacksonville - South
2.5 star property
16.1 km from Isle of Palms
7.6 out of 10, Good, (644)
"I love the hotel and enjoyed my stay."
United States
Marcus
The price is ₹5,753
₹6,529 total
includes taxes & fees
11 Dec - 12 Dec
WoodSpring Suites Jacksonville - South
Exterior
Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
3.5 star property
11.8 km from Isle of Palms
9.2 out of 10, Wonderful, (1002)
"Very nice stay "
United States
Timmothy
The price is ₹10,247
₹11,630 total
includes taxes & fees
21 Dec - 22 Dec
Hotel Indigo Jacksonville-Deerwood Park by IHG
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
4 km from Isle of Palms
8.6 out of 10, Excellent, (1004)
"Good location for a family vacation "
United States
Angel
The price is ₹9,438
₹10,712 total
includes taxes & fees
19 Dec - 20 Dec
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1001)
"Good hotel!"
United States
Charlie
The price is ₹8,022
₹9,105 total
includes taxes & fees
21 Dec - 22 Dec
Sheraton Jacksonville Hotel
Free daily buffet breakfast
Comfort Suites Baymeadows Near Butler Blvd

Comfort Suites Baymeadows Near Butler Blvd

Comfort Suites Baymeadows Near Butler Blvd
3.0 star property
14.5 km from Isle of Palms
8.2 out of 10, Very good, (1000)
"Enjoyed our stay! Staff was awesome....very clean and quiet stay."
United States
Rita
The price is ₹8,721
₹9,899 total
includes taxes & fees
21 Dec - 22 Dec
Comfort Suites Baymeadows Near Butler Blvd
Daily cooked-to-order breakfast for a fee
Hilton Garden Inn Jacksonville Downtown Southbank

Hilton Garden Inn Jacksonville Downtown Southbank

Hilton Garden Inn Jacksonville Downtown Southbank
3.0 star property
21.9 km from Isle of Palms
8.4 out of 10, Very good, (1000)
"The hotel es very nice & very well located near the San Marco arear. "
United States
Julio
The price is ₹8,928
₹10,133 total
includes taxes & fees
15 Dec - 16 Dec
Hilton Garden Inn Jacksonville Downtown Southbank
Lobby
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.8 km from Isle of Palms
9.0 out of 10, Wonderful, (1009)
"Great stay!!!"
United States
Michael
The price is ₹10,426
₹11,625 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms

Find the best Isle of Palms areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Southside

If you're spending some time in Southside, St. Johns Town Center and Merill Road Shopping Center are top sights worth seeing.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Cummer Museum of Art and Gardens featuring art and interior views as well as a couple
Photo by Visit Jacksonville
Open Photo by Visit Jacksonville

Northwest

While visiting Northwest, you might make a stop by sights like Cummer Museum of Art and Gardens and Jacksonville-Baldwin Rail Trail.

Top Isle of Palms Hotel Reviews

Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport

10/10 Excellent
"Very nice venue, with a beautiful and spacious suite!"
Stephen 1-night trip
Posted 9 hours ago
Hyatt Place Jacksonville Airport

Explore a world of travel with Expedia

Frequently asked questions

What is Isle of Palms like?
Travellers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighbourhood.
What's a favourite hotel to stay in Isle of Palms?
Based on Expedia customer reviews, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is the highest ranked property in Isle of Palms. This hotel offers free breakfast and an outdoor pool.
How many hotels should I expect to find in Isle of Palms?
Expedia has 37 hotels and other accommodation options in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to view the best deals available in Isle of Palms.
What is there to do in this Jacksonville Beach neighbourhood?
A few places to visit in the area around Isle of Palms include Adventure Landing, Cradle Creek Preserve and Jacksonville Beach Golf Club. While you're out sightseeing in Jacksonville Beach, make sure that you visit other sights such as Windsor Parke Golf Club or Players by the Sea.