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Our top choices for Isle of Palms hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (617 reviews)
"Had a great experience while here. Rooms were clean and spacious. Will definitely stay here again."
United States
LISA
The price is ₹13,805
₹15,669 total
includes taxes & fees
20 Nov - 21 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
2.1 km from Isle of Palms
9.2 out of 10, Wonderful, (389 reviews)
"A beautiful place will stay there again"
United States
Brandy
The price is ₹15,087
₹17,124 total
includes taxes & fees
21 Nov - 22 Nov
Hilton Jacksonville at Mayo Clinic near Beaches

3. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
3 km from Isle of Palms
9.0 out of 10, Wonderful, (1,004 reviews)
"Loved the room, and the little cheese omelets at breakfast were good!"
United States
Kerry
The price is ₹12,010
₹13,631 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

4. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.3 km from Isle of Palms
9.2 out of 10, Wonderful, (1,001 reviews)
"Great place to stay"
United States
Bobby
The price is ₹11,082
₹12,578 total
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Express Jacksonville Beach by IHG

5. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
3 km from Isle of Palms
9.2 out of 10, Wonderful, (669 reviews)
"The room was very clean and comfortable. It would be nice to have the breakfast time last longer than 9:00am though."
United States
Lana
The price is ₹11,551
₹13,111 total
includes taxes & fees
22 Nov - 23 Nov
TownePlace Suites by Marriott Jacksonville East

6. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.6 km from Isle of Palms
8.8 out of 10, Excellent, (4,660 reviews)
"really enjoyed our stay"
United States
Lavorus
The price is ₹13,841
₹15,710 total
includes taxes & fees
9 Nov - 10 Nov
Margaritaville Jacksonville Beach

7. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1,002 reviews)
"Would stay again"
United States
Williams
The price is ₹11,438
₹12,982 total
includes taxes & fees
8 Nov - 9 Nov
Best Western Oceanfront

8. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
Oceanfront, 4.5 km from Isle of Palms
9.0 out of 10, Wonderful, (817 reviews)
"Lovely hotel"
United States
Ovidiu
The price is ₹15,885
₹18,030 total
includes taxes & fees
22 Nov - 23 Nov
Springhill Suites By Marriott Jacksonville Beach Oceanfront

9. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.2 km from Isle of Palms
9.6 out of 10, Exceptional, (597 reviews)
"always a great stay. although this is our second time staying and something was broken in the bathroom."
United States
ariel
The price is ₹15,210
₹17,264 total
includes taxes & fees
15 Nov - 16 Nov
Element by Marriott Jacksonville Beach

10. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
2.5 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (982 reviews)
"The staff was very welcoming,and friendly ."
United States
Janice
The price is ₹9,735
₹11,049 total
includes taxes & fees
22 Nov - 23 Nov
Tru By Hilton Jacksonville St Johns Town Center

11. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,195 reviews)
"Nice hotel"
United States
Becky
The price is ₹10,443
₹11,853 total
includes taxes & fees
19 Nov - 20 Nov
Hyatt Place Jacksonville / St. Johns Town Center

12. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.9 km from Isle of Palms
9.4 out of 10, Exceptional, (247 reviews)
"Terrific location and accommodations to match!"
United States
William
The price is ₹10,903
₹12,375 total
includes taxes & fees
11 Nov - 12 Nov
Hyatt Studios Jacksonville/St Johns Town Center

13. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,251 reviews)
"Excellent place to stay if spending time at Mayo"
United States
Jeffrey
The price is ₹11,176
₹12,684 total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

14. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.9 km from Isle of Palms
9.0 out of 10, Wonderful, (1,029 reviews)
"Great bed and breakfast"
United States
Gregory
The price is ₹10,014
₹11,366 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

15. Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,001 reviews)
"Staff was real nice rooms were clean. Bartender was real nice facilities looked amazing."
United States
Jarvon
The price is ₹11,310
₹12,837 total
includes taxes & fees
22 Nov - 23 Nov
Sheraton Jacksonville Hotel

16. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 5 km from Isle of Palms
8.6 out of 10, Excellent, (1,004 reviews)
"friendly and helpful staff. Breakfast was very good."
United States
Daniel
The price is ₹13,439
₹15,253 total
includes taxes & fees
22 Nov - 23 Nov
Fairfield Inn & Suites by Marriott Jacksonville Beach

17. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.8 km from Isle of Palms
8.6 out of 10, Excellent, (1,001 reviews)
"Great Hotel"
United States
Josh
The price is ₹8,170
₹9,273 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Jacksonville E 295 Baymeadows by IHG

18. Dune House Hotel & Spa

Dune House Hotel & Spa
4.5 star property
6.7 km from Isle of Palms
8.8 out of 10, Excellent, (1,000 reviews)
"Awesome place!"
United States
Robert L
The price is ₹17,400
₹23,788 total
includes taxes & fees
23 Nov - 24 Nov
Dune House Hotel & Spa

19. Casa Marina Hotel

Casa Marina Hotel
3.0 star property
Oceanfront, 4.6 km from Isle of Palms
8.4 out of 10, Very good, (1,002 reviews)
"Great location just very old and towels were gray instead of a clean white"
United States
Brian
The price is ₹15,214
₹17,268 total
includes taxes & fees
29 Nov - 30 Nov
Casa Marina Hotel

20. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
3.0 star property
13.3 km from Isle of Palms
9.2 out of 10, Wonderful, (756 reviews)
"Lovely stay"
United States
Chloie Marie
The price is ₹9,086
₹10,313 total
includes taxes & fees
15 Nov - 16 Nov
Courtyard by Marriott Jacksonville I-295/East Beltway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Isle of Palms

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
9.4
Exceptional
617 reviews
View
A buffet with multiple self-service stations, including omelets and other prepared foods.
Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
9.2
Wonderful
1,001 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
9.0
Wonderful
1,004 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
9.2
Wonderful
389 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
3.0 star property
9.2
Wonderful
669 reviews
View

Where to stay in Isle of Palms

Find the best Isle of Palms areas for the activities you enjoy most.

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Top Isle of Palms Hotel Reviews

Frequently asked questions

What is Isle of Palms like?
Travellers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighbourhood.
What's a favourite hotel to stay in Isle of Palms?
Based on our traveller data, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is one of the top choices for your stay in Isle of Palms. This hotel is a short 6-minute walk from Mayo Clinic Florida, and it offers free breakfast and an outdoor pool.
How many hotels should I expect to find in Isle of Palms?
Expedia has 37 hotels and other accommodation options in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to view the best deals available in Isle of Palms.
What is there to do in this Jacksonville Beach neighbourhood?
A few places to visit in the area around Isle of Palms include Cradle Creek Preserve, Jacksonville Beach Golf Club and Windsor Parke Golf Club. While you're out sightseeing in Jacksonville Beach, make sure that you visit other sights such as Players by the Sea or Rhoda Martin Cultural Heritage Center.