Search Hotels in East Main Street, Grand Junction

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
16 Dec - 17 Dec
Tomorrow
17 Dec - 18 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Main Street hotels

Land view from property
The Homestead

The Homestead

The Homestead
4.5 star property
20.4 km from East Main Street
10.0 out of 10, Exceptional, (63)
"Very beautiful setting in a cute town famed for its Palisade Peaches!"
United States
Ronald
The price is ₹16,167
₹17,020 total
includes taxes & fees
21 Dec - 22 Dec
The Homestead
Exterior
Spoke and Vine Motel

Spoke and Vine Motel

Spoke and Vine Motel
2.5 star property
17.4 km from East Main Street
9.8 out of 10, Exceptional, (158)
"Spoke and Vine is such a cute motel! The staff was very friendly and the lobby bar area is very cute! They have great beverages on tap and comfortable chairs to sit in. The rooms are small but have everything you need for the stay. And they will even bring breakfast to you in the morning! "
United States
Emily
The price is ₹12,573
₹14,032 total
includes taxes & fees
22 Dec - 23 Dec
Spoke and Vine Motel
Fireplace
Castle Creek B&B

Castle Creek B&B

Castle Creek B&B
3.5 star property
3.4 km from East Main Street
9.8 out of 10, Exceptional, (206)
"Very pleasant stay…Incredible breakfast"
United States
Michele
Castle Creek B&B
Lobby
Comfort Inn Grand Junction I-70

Comfort Inn Grand Junction I-70

Comfort Inn Grand Junction I-70
2.5 star property
Horizon Drive District, 5.4 km from East Main Street
8.6 out of 10, Excellent, (1003)
"The room was comfortable and clean, the staff was very accommodating and the breakfast was nice with a clean dinning room "
United States
John
The price is ₹7,267
₹8,332 total
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn Grand Junction I-70
Lobby
Best Western Grande River Inn & Suites

Best Western Grande River Inn & Suites

Best Western Grande River Inn & Suites
2.5 star property
8.7 km from East Main Street
8.8 out of 10, Excellent, (792)
"Room and breakfast was typucal, ut bummed the pool and hot tub were closed."
United States
Phil
The price is ₹8,378
₹8,819 total
includes taxes & fees
29 Dec - 30 Dec
Best Western Grande River Inn & Suites
Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi
Econo Lodge Grand Junction North

Econo Lodge Grand Junction North

Econo Lodge Grand Junction North
2.0 star property
Horizon Drive District, 5.2 km from East Main Street
8.4 out of 10, Very good, (1000)
"Hotel was easy to find and worked quite well for a good night sleep after driving 13 hours. "
United States
Peter
The price is ₹5,266
₹6,038 total
includes taxes & fees
24 Dec - 25 Dec
Econo Lodge Grand Junction North
Dining
La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction

La Quinta Inn & Suites by Wyndham Grand Junction
3.0 star property
Horizon Drive District, 5.4 km from East Main Street
8.8 out of 10, Excellent, (2728)
"Easy to check-in was a great quick stay"
United States
Stephanie
The price is ₹6,786
₹7,781 total
includes taxes & fees
22 Dec - 23 Dec
La Quinta Inn & Suites by Wyndham Grand Junction
Modern Tiny Home on the Colo. River (9) | Individually decorated, free WiFi, bed sheets
Camp Eddy

Camp Eddy

Camp Eddy
1.0 star property
Pear Park, 1.5 km from East Main Street
9.4 out of 10, Exceptional, (291)
"The location was super close to everything and I love the community they're building at Camp Eddy."
United States
Stephanie ML
The price is ₹5,553
₹11,048 total
includes taxes & fees
1 Jan - 2 Jan 2026
Camp Eddy
Lobby
Doubletree Hotel Grand Junction

Doubletree Hotel Grand Junction

Doubletree Hotel Grand Junction
4.0 star property
Horizon Drive District, 5 km from East Main Street
8.2 out of 10, Very good, (1002)
"Good value, nice big room, convenient"
United States
Kathy
The price is ₹7,965
₹9,132 total
includes taxes & fees
13 Jan - 14 Jan 2026
Doubletree Hotel Grand Junction
Deluxe Room, 1 King Bed | Desk, blackout curtains, iron/ironing board, free WiFi
Ville 718

Ville 718

Ville 718
2.5 star property
Horizon Drive District, 4.6 km from East Main Street
6.8 out of 10, (351)
"Very nice quiet place while traveling through town. "
United States
Shane
The price is ₹5,335
₹6,117 total
includes taxes & fees
18 Dec - 19 Dec
Ville 718
Exterior
Courtyard by Marriott Grand Junction

Courtyard by Marriott Grand Junction

Courtyard by Marriott Grand Junction
3.0 star property
Horizon Drive District, 5.6 km from East Main Street
8.4 out of 10, Very good, (1001)
"Friendly staff and clean room "
United States
Jennifer
The price is ₹8,166
₹9,363 total
includes taxes & fees
28 Dec - 29 Dec
Courtyard by Marriott Grand Junction
Exterior
Holiday Inn & Suites Grand Junction by IHG

Holiday Inn & Suites Grand Junction by IHG

Holiday Inn & Suites Grand Junction by IHG
3.0 star property
Horizon Drive District, 5.4 km from East Main Street
8.6 out of 10, Excellent, (1001)
"Room clean and comfortable, staff was awesome and attentive "
United States
Kirstin
The price is ₹8,075
₹9,259 total
includes taxes & fees
5 Jan - 6 Jan 2026
Holiday Inn & Suites Grand Junction by IHG
Reception
Ramada by Wyndham Grand Junction

Ramada by Wyndham Grand Junction

Ramada by Wyndham Grand Junction
2.5 star property
Horizon Drive District, 5.3 km from East Main Street
8.4 out of 10, Very good, (1862)
"We very much enjoyed our stay there!"
United States
Kathryn
The price is ₹5,303
₹6,081 total
includes taxes & fees
22 Dec - 23 Dec
Ramada by Wyndham Grand Junction
Restaurant
Tru by Hilton Grand Junction Downtown

Tru by Hilton Grand Junction Downtown

Tru by Hilton Grand Junction Downtown
2.5 star property
Historic Grand Junction, 1.4 km from East Main Street
9.2 out of 10, Wonderful, (981)
"Very nice hotel and would choose it again"
United States
Billy
The price is ₹7,186
₹8,239 total
includes taxes & fees
8 Jan - 9 Jan 2026
Tru by Hilton Grand Junction Downtown
Terrace/patio
Hotel Maverick

Hotel Maverick

Hotel Maverick
4.0 star property
Capitol Hill, 1.6 km from East Main Street
9.6 out of 10, Exceptional, (1001)
"Excellent place to stay in Grand Junction. "
United States
Steve
Hotel Maverick
Seasonal outdoor pool, pool umbrellas
Wine Country Inn Palisade

Wine Country Inn Palisade

Wine Country Inn Palisade
3.5 star property
17.1 km from East Main Street
9.6 out of 10, Exceptional, (1003)
"Everything about our stay was excellent and we will definitely stay there in the future."
United States
Bill
Wine Country Inn Palisade
Exterior
La Quinta Inn & Suites by Wyndham Fruita

La Quinta Inn & Suites by Wyndham Fruita

La Quinta Inn & Suites by Wyndham Fruita
3.0 star property
18.8 km from East Main Street
8.4 out of 10, Very good, (1000)
"Clean rooms good breakfast "
United States
Bryan
The price is ₹6,277
₹7,173 total
includes taxes & fees
21 Dec - 22 Dec
La Quinta Inn & Suites by Wyndham Fruita
Restaurant
Hampton Inn Grand Junction Downtown/Historic Main Street

Hampton Inn Grand Junction Downtown/Historic Main Street

Hampton Inn Grand Junction Downtown/Historic Main Street
2.5 star property
Historic Grand Junction, 1.5 km from East Main Street
8.8 out of 10, Excellent, (1004)
"Very clean, well managed, and a nice overall stay"
United States
Jeff
The price is ₹8,110
₹9,299 total
includes taxes & fees
25 Dec - 26 Dec
Hampton Inn Grand Junction Downtown/Historic Main Street
Lobby
Comfort Inn & Suites Fruita - Grand Junction

Comfort Inn & Suites Fruita - Grand Junction

Comfort Inn & Suites Fruita - Grand Junction
2.5 star property
18.5 km from East Main Street
8.4 out of 10, Very good, (1004)
"The location was convenient and the staff was friendly. "
United States
Charles
The price is ₹6,149
₹7,026 total
includes taxes & fees
18 Dec - 19 Dec
Comfort Inn & Suites Fruita - Grand Junction
Free daily continental breakfast
Super 8 by Wyndham Fruita

Super 8 by Wyndham Fruita

Super 8 by Wyndham Fruita
2.0 star property
18.5 km from East Main Street
8.4 out of 10, Very good, (1000)
"Nice place with lots of food choices within a walkable block."
United States
Daniel
The price is ₹5,787
₹6,613 total
includes taxes & fees
21 Dec - 22 Dec
Super 8 by Wyndham Fruita
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in East Main Street

Find the best East Main Street areas for the activities you enjoy most.

Redlands

You'll enjoy the mountain views and wineries in Redlands. You might want to make time for a stop at Colorado National Monument or Redlands Mesa Golf Club.

Downtown

Though Downtown may not have many top sights, you can venture to the surrounding area to see attractions like Western Colorado Botanical Gardens and Bananas Fun Park.

Pear Park

While visiting Pear Park, you might make a stop by sights like Colorado River and James M. Robb – Colorado River State Park.

Historic Grand Junction

Visitors highly recommend Historic Grand Junction for its abundant dining options, and you can make a stop by Museum of the West while you're in town.

Horizon Drive District

Horizon Drive District might not have many top sights, but Grand Junction Motor Speedway and Canyon View Park are two attractions nearby that you can check out.

Top East Main Street Hotel Reviews

Clarion Inn Grand Junction

Clarion Inn Grand Junction

10/10 Excellent
"We enjoyed our stay. Very family friendly and lots of seating for breakfast. The pool and hot tub were both nice temps. "
Breanna 2-night trip
Posted 2 days ago
Clarion Inn Grand Junction

Explore a world of travel with Expedia

Frequently asked questions

What's it like in East Main Street?
Travellers will be sure to enjoy their time in Grand Junction's East Main Street neighbourhood.
How many hotels can I expect to find in the East Main Street area?
If you're searching for places to stay in Grand Junction, Expedia has something to meet your needs with 22 East Main Street hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in East Main Street, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to get the best deals in East Main Street.
What is there to do around this Grand Junction neighbourhood?
A few places to visit in the area around East Main Street include Museum of the West, Western Colorado Botanical Gardens and Elliott Tennis Center. While you're out sightseeing, Western Colorado Center for the Arts and Tennis Junction Indoor Center are a couple of additional sights to visit in Grand Junction.