A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.

Compare and book 5 Star hotels in Panama City, Panamá Province

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama City 5 Star Hotels

Tonight
11 Oct - 12 Oct
Tomorrow
12 Oct - 13 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Panama City 5-star hotels

A modern bathroom with a toilet, shower, and bathtub.
A modern hotel room with a dining area, a TV, and a city view.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Avanel
₹12,764
₹14,040 total
includes taxes & fees
21 Oct - 22 Oct
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A modern building with a rooftop lounge area, large windows, and a balcony overlooking a cityscape.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
₹25,407
₹27,948 total
includes taxes & fees
31 Oct - 1 Nov
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
₹33,954
₹37,349 total
includes taxes & fees
3 Nov - 4 Nov
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
₹13,059
₹14,365 total
includes taxes & fees
31 Oct - 1 Nov
Renaissance Panama City Hotel
A poolside area with lounge chairs and a view of the ocean.
A terrace with seating and a view of the ocean.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.

5. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Detra Dorsey
₹27,008
₹29,709 total
includes taxes & fees
7 Nov - 8 Nov
JW Marriott Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A modern interior with a central seating area, potted plants, and a staircase.
A spacious lobby with a curved ceiling, a central staircase, and a reception desk.
A modern building with a sign reading 'HYATT REGENCY.'

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Mariah
₹18,089
₹19,898 total
includes taxes & fees
17 Oct - 18 Oct
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
A pool with a central water feature, surrounded by seating areas and potted plants.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.
The entrance of The Santa Maria with a covered walkway and a view of the interior.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Carmen
₹26,771
₹29,449 total
includes taxes & fees
1 Nov - 2 Nov
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.

8. W Panama

W Panama
Bella Vista
United States
Naomi
₹22,365
₹24,602 total
includes taxes & fees
1 Nov - 2 Nov
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A modern interior with a spiral staircase, a large window, and a seating area.
A modern bar area with seating and a view of the city.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Simon
₹23,763
₹26,139 total
includes taxes & fees
6 Nov - 7 Nov
Hilton Panama
A hotel with a pool, beach, and palm trees.
A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Anna
₹19,937
₹21,931 total
includes taxes & fees
25 Oct - 26 Oct
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A cozy outdoor seating area with a wooden bench and white tables, surrounded by lush greenery and potted plants.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
₹24,087
₹26,496 total
includes taxes & fees
17 Oct - 18 Oct
Bristol Panama, a Registry Collection Hotel
Lobby
Banquet hall
Breakfast area
Bar (on property)

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
₹9,831
₹10,859 total
includes taxes & fees
4 Nov - 5 Nov
Waymore Hotel Spa and Casino
Terrace/patio
Outdoor spa tub
Casino
Room

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
₹25,249
₹27,889 total
includes taxes & fees
4 Nov - 5 Nov
Megapolis Hotel Panamá
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
₹13,446
₹15,429 total
9 Nov - 10 Nov
includes taxes & fees
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
₹19,653
₹21,618 total
9 Nov - 10 Nov
includes taxes & fees
9/10 Wonderful! (1,013 reviews)
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
₹15,808
₹17,389 total
31 Oct - 1 Nov
includes taxes & fees
8.6/10 Excellent! (1,778 reviews)
Megapolis Hotel Panamá
Still don't see what you're looking for?
See all properties in Panama City.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City
A city skyline with high-rise buildings, a calm waterfront, and a sunset sky.

Top Panama City Hotel Reviews

Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"Exactly what you would expect from hyatt resort"
Nehemiah 3-night trip
Posted 3 hours ago
Hyatt Regency Panama City
JW Marriott Panama

JW Marriott Panama

10/10 Excellent
"N/A"
Rhonda 3-night trip
Posted 4 hours ago
JW Marriott Panama

Find out more about Panama City

Stay in Luxury: 5 Star Hotels in Panama City

There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming leisure time. Treat yourself with a stay in a 5-star hotel during your Panama City trip. You'll join the multitudes of holidaymakers who have made Panama City so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Panama City and indulge in the finer things in life for a while.

5-Star Hotels in Panama City

You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs. 

But you aren't going to spend your entire holiday in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama City are waiting for you to relax after an exciting day.

Make Your Escape

The results are in, and Panama City 5-star hotels are the place to be when you book your next holiday. If you've been dreaming about a holiday set here, then go ahead and book it. It's time to plan your next great escape -- this is a great time to find 5-star hotel deals in Panama City! Choose one of our Panama City 5-star hotels today and soothe yourself in luxe surroundings at your convenience.

Expedia India is rated 4 stars by Feefo based on 1038 reviews

Frequently asked questions

What are the best 5-star hotels in Panama City?
According to Expedia guest reviews, Bristol Panama, a Registry Collection Hotel, W Panama and Waldorf Astoria Panama are among the top 5-star hotels in Panama City. Providing top-quality amenities and unmatchable service, you'll enjoy a luxurious and memorable stay.
How much does it cost to stay in a 5-star hotel in Panama City?
How much you pay for a 5-star hotel in Panama City can vary according to when you prefer to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to find the best deal on a luxurious getaway.
  • Search for the lowest price per night from ₹15,429
What makes a hotel 5 stars in Panama City?
From fine dining restaurants and 24-hour gyms to swimming pools and the finest bedding, the 5-star experience in Panama City is all about comfort and luxury. But it takes more than just top-notch amenities to receive a 5-star rating. Hotels also have to offer remarkable guest-centric services like in-room beauty treatments, on-site laundry and dry cleaning and room service any time day or night.

Explore a world of travel with Expedia