Compare and book 5 Star hotels in Panama City, Panamá Province

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Panama City 5 Star Hotels

Top Panama City 5 Star Hotels

Hotel Riu Plaza Panama

5.0 star property
9.0 out of 10, Wonderful, (4251)
"Really nice hotel ,close to everything "
The price is ₹10,789
₹11,867 total
includes taxes & fees
22 Sept - 23 Sept
Hotel Riu Plaza Panama

JW Marriott Panama

5.0 star property
8.8 out of 10, Excellent, (1001)
"Great stay"
The price is ₹20,144
₹22,158 total
includes taxes & fees
19 Sept - 20 Sept
JW Marriott Panama

Waldorf Astoria Panama

5.0 star property
9.0 out of 10, Wonderful, (1000)
"Great hotel for my recent stay in Panam "
The price is ₹19,743
₹21,718 total
includes taxes & fees
4 Oct - 5 Oct
Waldorf Astoria Panama

The Westin Playa Bonita Panama

5.0 star property
8.0 out of 10, Very good, (1000)
"Excelente hotel. "
The price is ₹13,404
₹14,745 total
includes taxes & fees
21 Sept - 22 Sept
The Westin Playa Bonita Panama

Renaissance Panama City Hotel

5.0 star property
9.0 out of 10, Wonderful, (59)
"Staff is excellent 👌 breakfast has great variety ! Great location "
The price is ₹9,074
₹9,982 total
includes taxes & fees
26 Sept - 27 Sept
Renaissance Panama City Hotel

Sofitel Legend Casco Viejo, Panama City

5.0 star property
9.8 out of 10, Exceptional, (507)
"Great stay"
The price is ₹25,769
₹28,346 total
includes taxes & fees
8 Oct - 9 Oct
Sofitel Legend Casco Viejo, Panama City

W Panama

5.0 star property
9.0 out of 10, Wonderful, (1002)
"Great hotel "
The price is ₹16,453
₹18,098 total
includes taxes & fees
10 Oct - 11 Oct
W Panama

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
9.6 out of 10, Exceptional, (604)
"Everything at this hotel was immaculate. From the service, to the food, the entire team was incredible and made our first time in Panama welcome."
The price is ₹19,433
₹21,376 total
includes taxes & fees
20 Sept - 21 Sept
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Hilton Panama

5.0 star property
8.8 out of 10, Excellent, (1005)
"The staff an the service is excellent. Everyone gives you personal attention "
The price is ₹20,144
₹22,158 total
includes taxes & fees
12 Oct - 13 Oct
Hilton Panama

Bristol Panama, a Registry Collection Hotel

5.0 star property
9.2 out of 10, Wonderful, (1003)
"A lovely hotel and excellent food and rooms and service. "
The price is ₹14,537
₹15,990 total
includes taxes & fees
11 Oct - 12 Oct
Bristol Panama, a Registry Collection Hotel

Megapolis Hotel Panamá

5.0 star property
8.4 out of 10, Very good, (1000)
"This is THE place to stay in Panama City... it's location, friendly accommodating staff, and the amenities are fantastic. The rooms were wonderful, clean and bright. We tried Tauro (steakhouse) and the Bazaar - they were both delicious and the service excellent. We literally partied like rock stars at their rooftop restaurant, and at the wonderful outdoor infinity pool as well. We will definitely be returning! "
Megapolis Hotel Panamá

Waymore Hotel Spa and Casino

5.0 star property
6.2 out of 10, (1000)
"Clean and safe. Lot of security."
Waymore Hotel Spa and Casino
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.
Still don't see what you're looking for?
See all properties in Panama City.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

Top Panama City Hotel Reviews

Find out more about Panama City

Find out more about Panama City

Stay in Luxury: 5 Star Hotels in Panama City

There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming leisure time. Treat yourself with a stay in a 5-star hotel during your Panama City trip. You'll join the multitudes of holidaymakers who have made Panama City so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Panama City and indulge in the finer things in life for a while.

5-Star Hotels in Panama City

You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs. 

But you aren't going to spend your entire holiday in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama City are waiting for you to relax after an exciting day.

Make Your Escape

The results are in, and Panama City 5-star hotels are the place to be when you book your next holiday. If you've been dreaming about a holiday set here, then go ahead and book it. It's time to plan your next great escape -- this is a great time to find 5-star hotel deals in Panama City! Choose one of our Panama City 5-star hotels today and soothe yourself in luxe surroundings at your convenience.


Expedia India is rated 4 stars by Feefo based on 1038 reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What are the best 5-star hotels in Panama City?
According to Expedia guest reviews, Bristol Panama, a Registry Collection Hotel, W Panama and Waldorf Astoria Panama are among the top 5-star hotels in Panama City. Providing top-quality amenities and unmatchable service, you'll enjoy a luxurious and memorable stay.
How much does it cost to stay in a 5-star hotel in Panama City?
How much you pay for a 5-star hotel in Panama City can vary according to when you prefer to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to find the best deal on a luxurious getaway.

  • Search for the lowest price per night from ₹10,748

What makes a hotel 5 stars in Panama City?
From fine dining restaurants and 24-hour gyms to swimming pools and the finest bedding, the 5-star experience in Panama City is all about comfort and luxury. But it takes more than just top-notch amenities to receive a 5-star rating. Hotels also have to offer remarkable guest-centric services like in-room beauty treatments, on-site laundry and dry cleaning and room service any time day or night.