Compare and book 5 Star hotels in Panama City, Panamá Province

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Our top choices for Panama City 5-star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4639)
"Awesome great place to stay "
United States
Herbert
The price is ₹11,007
₹12,108 total
includes taxes & fees
15 Dec - 16 Dec
Hotel Riu Plaza Panama

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1004)
"I loved everything about my stay "
United States
Stephanie
The price is ₹16,141
₹17,755 total
includes taxes & fees
17 Dec - 18 Dec
Waldorf Astoria Panama

W Panama

W Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1001)
"It is a hotel with very comfortable and nicely designed rooms in the heart of Panama City. The hotel staff is efficient, attentive and friendly."
United States
SVETLANA
The price is ₹18,624
₹20,486 total
includes taxes & fees
20 Dec - 21 Dec
W Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1007)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ₹25,806
₹28,386 total
includes taxes & fees
3 Jan - 4 Jan 2026
JW Marriott Panama

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (555)
"Great hotel and location "
United Kingdom
Russell
The price is ₹33,572
₹36,929 total
includes taxes & fees
15 Dec - 16 Dec
Sofitel Legend Casco Viejo, Panama City

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1002)
"Great place to stay."
United States
Salvador
The price is ₹16,732
₹18,405 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very good, (1005)
"Our stay was very nice, the service the hotel provides is wonderful, I highly recommend it"
United States
Mayra Alexandra Montes
The price is ₹17,887
₹19,676 total
includes taxes & fees
14 Dec - 15 Dec
The Westin Playa Bonita Panama

Renaissance Panama City Hotel

Renaissance Panama City Hotel
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (94)
"Great location and amazing staff"
United States
Aziz
The price is ₹10,427
₹11,469 total
includes taxes & fees
17 Dec - 18 Dec
Renaissance Panama City Hotel

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is ₹17,951
₹19,746 total
includes taxes & fees
3 Jan - 4 Jan 2026
Bristol Panama, a Registry Collection Hotel

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ₹20,831
₹22,914 total
includes taxes & fees
12 Dec - 13 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Megapolis Hotel Panamá

Megapolis Hotel Panamá
5.0 star property
San Francisco
8.4 out of 10, Very good, (1000)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá

Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
5.0 star property
Bella Vista
6.2 out of 10, (1000)
"It has a nice casino and it's very conveniently located. Breakfast was very good as well. Staff very helpful and attention oriented. Good experience "
United States
Aldo
Waymore Hotel Spa and Casino
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Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

Panoramic view at the Downtown of Panama City - Panama

Top Panama City Hotel Reviews

Find out more about Panama City

Stay in Luxury: 5 Star Hotels in Panama City

There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming leisure time. Treat yourself with a stay in a 5-star hotel during your Panama City trip. You'll join the multitudes of holidaymakers who have made Panama City so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Panama City and indulge in the finer things in life for a while.

5-Star Hotels in Panama City

You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs. 

But you aren't going to spend your entire holiday in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama City are waiting for you to relax after an exciting day.

Make Your Escape

The results are in, and Panama City 5-star hotels are the place to be when you book your next holiday. If you've been dreaming about a holiday set here, then go ahead and book it. It's time to plan your next great escape -- this is a great time to find 5-star hotel deals in Panama City! Choose one of our Panama City 5-star hotels today and soothe yourself in luxe surroundings at your convenience.


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Frequently asked questions

What are the best 5-star hotels in Panama City?
According to Expedia guest reviews, Bristol Panama, a Registry Collection Hotel, W Panama and Waldorf Astoria Panama are among the top 5-star hotels in Panama City. Providing top-quality amenities and unmatchable service, you'll enjoy a luxurious and memorable stay.
How much does it cost to stay in a 5-star hotel in Panama City?
How much you pay for a 5-star hotel in Panama City can vary according to when you prefer to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to find the best deal on a luxurious getaway.

  • Search for the lowest price per night from ₹10,876

What makes a hotel 5 stars in Panama City?
From fine dining restaurants and 24-hour gyms to swimming pools and the finest bedding, the 5-star experience in Panama City is all about comfort and luxury. But it takes more than just top-notch amenities to receive a 5-star rating. Hotels also have to offer remarkable guest-centric services like in-room beauty treatments, on-site laundry and dry cleaning and room service any time day or night.

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