The Best Hotels Closest to 21c Museum Hotel in Louisville - 2026 Updated Prices

Q: What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 250 hotels and other accommodation options you'll find within a mile.

Q: What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Holiday Inn Express & Suites Louisville Downtown by IHG .

Q: How many hotels are there near 21c Museum Hotel?

Expedia has 250 hotels and other accommodation options within a mile from 21c Museum Hotel.

Q: If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

Q: What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Union Station. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

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Our top choices for 21c Museum Hotel hotels

1. Market Street Inn

2.1 km from 21c Museum Hotel

Anissa

₹17,963 total

includes taxes & fees

6 Aug - 7 Aug

2. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

₹15,462 total

includes taxes & fees

11 Aug - 12 Aug

3. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Brad

₹16,113 total

includes taxes & fees

17 Aug - 18 Aug

4. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Jasmine

₹24,593 total

includes taxes & fees

16 Aug - 17 Aug

5. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Anthony

₹13,998 total

includes taxes & fees

15 Aug - 16 Aug

6. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Torrence

₹13,712 total

includes taxes & fees

12 Aug - 13 Aug

7. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Jennifer

₹18,084 total

includes taxes & fees

30 Aug - 31 Aug

2 restaurants; breakfast and dinner served

8. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Jennifer

₹13,706 total

includes taxes & fees

10 Aug - 11 Aug

3 bars/lounges, cocktail bar, lobby lounge

9. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heriberto

₹17,867 total

includes taxes & fees

9 Aug - 10 Aug

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Jeffery

₹19,409 total

includes taxes & fees

23 Aug - 24 Aug

11. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

nicolle

₹18,499 total

includes taxes & fees

27 Aug - 28 Aug

12. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Michael

₹10,881 total

includes taxes & fees

3 Sept - 4 Sept

13. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Brooklyn

₹12,420 total

includes taxes & fees

4 Sept - 5 Sept

14. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Zacarias

₹10,774 total

includes taxes & fees

16 Aug - 17 Aug

15. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

David

₹13,651 total

includes taxes & fees

16 Aug - 17 Aug

16. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Christina

₹15,144 total

includes taxes & fees

13 Aug - 14 Aug

17. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Angie

₹13,382 total

includes taxes & fees

6 Aug - 7 Aug

4 restaurants; breakfast, lunch and dinner served

18. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

marcus

₹16,289 total

includes taxes & fees

19 Aug - 20 Aug

19. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Spencer

₹15,553 total

includes taxes & fees

19 Aug - 20 Aug

20. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Marcus

₹14,136 total

includes taxes & fees

16 Aug - 17 Aug

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Property class	Guest rating
Market Street Inn	3.5 star property	9.8 Exceptional 122 reviews	View
DuPont Mansion Bed & Breakfast	2.0 star property	9.6 Exceptional 143 reviews	View
Stellar Suites	4.5 star property	9.6 Exceptional 145 reviews	View
Hotel Distil, Autograph Collection	4.0 star property	9.6 Exceptional 490 reviews	View
The Brown Hotel	4.5 star property	9.4 Exceptional 1,282 reviews	View

Top 21c Museum Hotel Hotel Reviews

21c Museum Hotel Louisville

10/10 Excellent

"We love 21C, whenever we travel that is our first go to hotel. We have one in our hometown and love what it offers and the rooms are phenomenal"

Homewood Suites by Hilton Louisville Downtown, KY

8/10 Good

"If you’re looking for a family hotel this is for you. If you are a couple looking for a place, this isn’t it. We picked this hotel because it had a pool and the location seemed like there were restaurants around to choose from. The breakfast was free but not great and the coffee was terrible. Plus the amount of people you had to deal with to get breakfast… not worth it. We got in the car and drove to Starbucks. The pool was so small and next to a window where anyone walking in the street would see you. Plus it was full of kids. Most of the restaurants were closed down and the homelessness and drug addicts made it feel uncomfortable to walk to Whiskey row or the casino. The rooms are huge, super clean and comfortable but we did have a kid running back and forth on the floor above. We called the front office and they went up there immediately and it was stopped. The employees and the hotel were very nice. I would just not stay here again based on the location and the amenities!"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 250 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Holiday Inn Express & Suites Louisville Downtown by IHG.

How many hotels are there near 21c Museum Hotel?

Expedia has 250 hotels and other accommodation options within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Union Station. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

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Our top choices for 21c Museum Hotel hotels

1. Market Street Inn

2. DuPont Mansion Bed & Breakfast

3. Stellar Suites

4. Hotel Distil, Autograph Collection

5. The Brown Hotel

6. Homewood Suites by Hilton Louisville Downtown, KY

7. The Grady

8. Tempo By Hilton Louisville Downtown Nulu

9. Omni Louisville Hotel

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

11. 21c Museum Hotel Louisville

12. Towneplace Suites By Marriott Louisville Downtown

13. Cambria Hotel Louisville Downtown-Whiskey Row

14. Moxy Louisville Downtown

15. AC Hotel Louisville Downtown

16. Hotel Genevieve part of JdV by Hyatt

17. Central Park Bed & Breakfast

18. Galt House Hotel Trademark Collection by Wyndham

19. Embassy Suites Louisville Downtown

20. Aloft by Marriott Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

21c Museum Hotel Louisville

Other attractions near 21c Museum Hotel

Louisville Science Center

Frequently asked questions

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