The Best Hotels Closest to 21c Museum Hotel in Louisville - 2026 Updated Prices

Q: What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 292 hotels and other accommodation options you'll find within a mile.

Q: What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel .

Q: How many hotels are there near 21c Museum Hotel?

Expedia has 292 hotels and other accommodation options within a mile from 21c Museum Hotel.

Q: If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

Q: What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

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Our top choices for 21c Museum Hotel hotels

A wooden staircase with a balustrade leading to a landing.

1. Market Street Inn

2.1 km from 21c Museum Hotel

"Such a lovely stay at the Market Street Inn. A very charming, comfortable and feels like home kind of place. Carol and Steve are just the kindest owners. They were responsive and accommodating and always available if needed. We also loved meeting Lisa, who made breakfast each morning and took care of any housekeeping needs. We felt like we were treated as family and not just guests. The area and location is perfect, SUCH a cute little town. Plenty of restaurants, shops and entertainment within...

Ryan

₹23,714 total

includes taxes & fees

4 Nov - 5 Nov

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

2. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

₹20,065 total

includes taxes & fees

4 Nov - 5 Nov

A grand lobby with ornate columns, plush seating, and a chandelier.

3. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

katisha

₹11,647 total

includes taxes & fees

25 Nov - 26 Nov

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

4. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Brian

₹22,689 total

includes taxes & fees

17 Nov - 18 Nov

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

5. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

peter

₹12,727 total

includes taxes & fees

27 Nov - 28 Nov

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

6. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

₹11,360 total

includes taxes & fees

26 Nov - 27 Nov

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

7. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

₹17,695 total

includes taxes & fees

9 Nov - 10 Nov

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

8. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Greg

₹17,390 total

includes taxes & fees

19 Nov - 20 Nov

A classical gold statue in front of a multi-story building with large windows and a brick facade.

9. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Erick

₹17,463 total

includes taxes & fees

24 Nov - 25 Nov

A modern bar area with a circular bar, multiple seating options, and a large screen.

10. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Trista

₹10,636 total

includes taxes & fees

23 Nov - 24 Nov

An outdoor dining area with a long table and wicker chairs, overhead lighting, and a view of the city.

11. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Jesse

₹15,978 total

includes taxes & fees

8 Nov - 9 Nov

A brick building with outdoor seating and a fire pit.

12. TownePlace Suites by Marriott Louisville North

2.2 km from 21c Museum Hotel

Lori M

₹12,011 total

includes taxes & fees

22 Nov - 23 Nov

A covered patio with a stone wall, a glass table, and a bench.

13. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Stephen

₹17,682 total

includes taxes & fees

8 Nov - 9 Nov

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

14. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Sheree

₹11,619 total

includes taxes & fees

29 Nov - 30 Nov

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

15. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Anthony

₹12,676 total

includes taxes & fees

26 Nov - 27 Nov

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

16. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Kevin

₹15,978 total

includes taxes & fees

8 Nov - 9 Nov

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

17. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

ERIC

₹15,208 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

18. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Chase

₹14,558 total

includes taxes & fees

23 Nov - 24 Nov

A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.

19. Louisville Marriott Downtown

Downtown Louisville, 0.7 km from 21c Museum Hotel

MILTON

₹18,736 total

includes taxes & fees

22 Nov - 23 Nov

A modern lobby with a central seating area, a reception desk, and a large screen.

20. Holiday Inn Express & Suites Louisville Downtown by IHG

Downtown Louisville, 0.3 km from 21c Museum Hotel

Lisa

₹10,390 total

includes taxes & fees

22 Nov - 23 Nov

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Property class	Guest rating
Market Street Inn	3.5 star property	9.8 Exceptional 127 reviews	View
DuPont Mansion Bed & Breakfast	4.0 star property	9.6 Exceptional 150 reviews	View
The Brown Hotel	4.5 star property	9.4 Exceptional 1,447 reviews	View
Omni Louisville Hotel	4.0 star property	9.4 Exceptional 2,216 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	3.0 star property	9.4 Exceptional 1,006 reviews	View

Top 21c Museum Hotel Hotel Reviews

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent

"It was close to downtown and the River area! We were able to go in and out of parking garage with no problems ! Staff was great-we needed extra towels and blanket !"

The Grady

8/10 Good

"It’s a nice hotel but definitely not 5⭐️the bed was not comfortable,the hotel was not busy and the room they gave us was mediocre@best ans being a Hilton platinum member an upgrade would’ve been appreciated,our room was freezing,not exactly the most hospitable staff member that booked us in,otherwise staff was nice,but again not 5 stars."

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 292 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels are there near 21c Museum Hotel?

Expedia has 292 hotels and other accommodation options within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

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Our top choices for 21c Museum Hotel hotels

1. Market Street Inn

2. DuPont Mansion Bed & Breakfast

3. The Brown Hotel

4. Omni Louisville Hotel

5. Homewood Suites by Hilton Louisville Downtown, KY

6. Tempo By Hilton Louisville Downtown Nulu

7. Stellar Suites

8. The Grady

9. 21c Museum Hotel Louisville

10. Cambria Hotel Louisville Downtown-Whiskey Row

11. Hotel Genevieve part of JdV by Hyatt

12. TownePlace Suites by Marriott Louisville North

13. Central Park Bed & Breakfast

14. Moxy Louisville Downtown

15. Aloft by Marriott Louisville Downtown

16. AC Hotel Louisville Downtown

17. Galt House Hotel Trademark Collection by Wyndham

18. Embassy Suites Louisville Downtown

19. Louisville Marriott Downtown

20. Holiday Inn Express & Suites Louisville Downtown by IHG

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Holiday Inn Express & Suites Louisville Downtown by IHG

Other attractions near 21c Museum Hotel

Louisville Science Center

Frequently asked questions

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