TOP Business Hotels in Little Italy, CA for 2026

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Our top choices for Little Italy business-friendly hotels

Outdoor pool, open 7:00 AM to 10:00 PM, free pool cabanas, pool loungers

Hilton Garden Inn San Diego Downtown/Bayside

Downtown San Diego

Diem

₹20,241 total

includes taxes & fees

14 Jun - 15 Jun

Courtyard by Marriott San Diego Downtown Little Italy

Downtown San Diego

Saundra

₹19,237 total

includes taxes & fees

14 Jun - 15 Jun

Suite, 1 Bedroom, Non Smoking | Living area | 32-inch LCD TV with premium TV channels, TV

Hampton Inn San Diego-Downtown

Downtown San Diego

Betty Ellen

₹16,369 total

includes taxes & fees

8 Jul - 9 Jul

Standard Room, 2 Queen Beds | In-room safe, desk, blackout curtains, iron/ironing board

Harborview Inn & Suites San Diego Harbor

Downtown San Diego

Workabeba

₹10,439 total

includes taxes & fees

14 Jun - 15 Jun

Porto Vista Hotel Downtown

Downtown San Diego

Elizabeth

₹14,096 total

includes taxes & fees

15 Jun - 16 Jun

Urban Boutique Hotel

Downtown San Diego

Martin

₹15,144 total

includes taxes & fees

14 Jun - 15 Jun

Residence Inn by Marriott San Diego Downtown

Downtown San Diego

Nathan

₹18,944 total

includes taxes & fees

6 Jul - 7 Jul

Crowne Plaza San Diego - Mission Valley by IHG

Mission Valley

amanda

₹13,734 total

includes taxes & fees

29 Jun - 30 Jun

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Top Little Italy Hotel Reviews

The Alcala Hotel Mission Valley/Seaworld

6/10 Okay

"Unfortunately they overbooked and were not able to give me a double bed room and had to go for the king last minute. Also, it was barely 10:45AM and I already had a man knocking hard on the door as I was changing getting ready to leave the room just checking to see if I was almost leaving, mind you checkout is at 11AM. I then went to the checkout desk and no one was there, I had to step into the dinning area and after a few minutes a girl came out, very snarky like I was supposed to know that key drop off was exiting the parking lot...Also, lots of noise in the early morning, I understand renovations are happening but not worth the price. Room looks very nice and fancy, bed was comfortable...overall the place could do better as far as customer service and treating guests with a lot more consideration."

The Sofia Hotel

8/10 Good

"While staying here, I was impressed with nearly everything The Sofia had to offer from the gorgeous rooms, the hotels view, helpful staff, and even complementary goodies in the lobby. I will say I was not a fan of having learning that you must pay to park here as it’s not included in your reservation. I also felt the property lacked more amenities for its guests like a hot tub or even a sort of breakfast voucher for their new restaurant downstairs. Overall, me and my plus one had a fantastic opportunity to stay here. 7.5/10"

San Diego Mission Bay Resort

10/10 Excellent

"Very family friendly resort ! We enjoyed the pool and the restaurant with our daughter’s family and our young granddaughters. The hotel was able to provide connecting rooms which was wonderful and kept us connected the entire time, they also accommodated an early check in for a small fee and a late check out , also for a small fee which was very nice when traveling with small children. Property is a little older and could use some refreshing but was clean and well maintained and the staff was very friendly, bar tenders were fabulous! Parking was super convenient and close. Walking path near the beach provides access to two close neighborhood parks. Would recommend and would return."

Frequently asked questions

Why book your business-friendly hotel in Little Italy with Expedia?

Here at Expedia, our job is to help you choose the ideal stay at the right price. From deluxe, corporate-friendly getaways to affordable hotels loaded with conveniences, you'll have your next work trip booked in a few easy clicks.

How can I find cheap business-friendly hotels in Little Italy?

When you're travelling for work in Little Italy, our "business friendly" filter will help you find the ideal hotel. From fast WiFi to meeting rooms and workspaces, they have the amenities you need to get the job done. Another tip? Refine your search by your preferred star rating and budget to see the most affordable accommodation.

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Check availability on Little Italy Business Hotels

Our top choices for Little Italy business-friendly hotels

Hilton Garden Inn San Diego Downtown/Bayside