Florida Keys Spa Holidays 2026

Plan, book, travel with confidence
Better together
Save up to ₹43,962 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL

3 hours drive from Duval Street

Stay at this luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their ...

9.2/10 Wonderful! (1,301 reviews)

Travellers like: full-service spa, sauna, steam room, massage

Travellers say...

They should have had a newsletter with activities.

Reviewed on 23 Mar 2026

Pier House Resort & Spa

1 Duval St Key West FL

11 min walk from Duval Street

Stay at this beach resort in Key West. Enjoy a full-service spa, a private beach and 2 bars/lounges. Our guests praise the pool and the helpful staff in their ...

9/10 Wonderful! (1,065 reviews)

Travellers like: full-service spa, massage, facials, manicures and pedicures

Travellers say...

Great location. The staff was great. The room was very clean.

Reviewed on 22 Mar 2026

Hyatt Centric Key West Resort and Spa

601 Front St Key West FL

11 min walk from Duval Street

Stay at this beach resort in Key West. Enjoy free Wi-Fi, a full-service spa and a marina. Our guests praise the pool and the helpful staff in their reviews. ...

9/10 Wonderful! (1,000 reviews)

Travellers like: full-service spa, massage, facials, manicures and pedicures

Travellers say...

The ocean and beach were visible from the room.

Reviewed on 14 Mar 2026

See all 8,335 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.