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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business centre and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (503 reviews)

Excellent breakfast and the host accommodated dietary needs.

Reviewed on 10 May 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in their reviews. ...

9.2/10 Wonderful! (1,004 reviews)

Couples like: full-service spa, bar

Travellers say...

Our sink didn't drain The shower didn't drain but the stopper didn't work, the cold water kept coming out of shower, so it didn't work to shower or take a bath

Reviewed on 2 May 2026

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Austin. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in ...

8.8/10 Excellent! (742 reviews)

Great staff

Reviewed on 19 Apr 2026

See all 1,207 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.