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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free breakfast, free parking and a business centre. Popular attractions Watkins Heritage Museum and Polish Cultural Institute ...

10/10 Exceptional! (364 reviews)

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Reviewed on 8 Dec 2025

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Stay at this 3.5-star spa hotel in Red Wing. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,002 reviews)

Couples like: full-service spa, bar

Travellers say...

Lovely room, great restaurant on site, free parking, nice staff.

Reviewed on 7 Dec 2025

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Stay at this business-friendly hotel in Austin. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in ...

8.8/10 Excellent! (717 reviews)

Friendly staff, clean room. Definitely would recommend.

Reviewed on 15 Dec 2025

See all 1,194 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.