Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the clean rooms in their reviews. Popular ...

5.8/10 (1,001 reviews)

"It was dated it felt dirty, our drawer with the television on top had a collapsed, broken splinter side I wouldn’t ever stay there again"

Reviewed on 25 Jun 2026

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Troy. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,000 reviews)

"The room was clean, amenities were good, staff were friendly and accommodating, and the customer service was excellent. I would definitely stay in the future when I have an event in the area."

Reviewed on 22 Jun 2026

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr Collinsville IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

7.4/10 Good! (1,000 reviews)

"Clean and cheaper than most"

Reviewed on 26 Jun 2026

See all 759 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.